ID A0A125S2T5_9FLAO Unreviewed; 486 AA.
AC A0A125S2T5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Glucosylceramidase {ECO:0000313|EMBL:AMD84530.1};
GN ORFNames=AXF12_02725 {ECO:0000313|EMBL:AMD84530.1};
OS Capnocytophaga haemolytica.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=45243 {ECO:0000313|EMBL:AMD84530.1, ECO:0000313|Proteomes:UP000065822};
RN [1] {ECO:0000313|Proteomes:UP000065822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 32990 {ECO:0000313|Proteomes:UP000065822};
RA Holder M.E., Ajami N.J., Petrosino J.F.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 30 family.
CC {ECO:0000256|ARBA:ARBA00005382, ECO:0000256|RuleBase:RU361188}.
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DR EMBL; CP014227; AMD84530.1; -; Genomic_DNA.
DR RefSeq; WP_066428108.1; NZ_LT906449.1.
DR AlphaFoldDB; A0A125S2T5; -.
DR STRING; 45243.AXF12_02725; -.
DR KEGG; chg:AXF12_02725; -.
DR OrthoDB; 9806701at2; -.
DR Proteomes; UP000065822; Chromosome.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR033452; GH30_C.
DR InterPro; IPR001139; Glyco_hydro_30.
DR InterPro; IPR033453; Glyco_hydro_30_TIM-barrel.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11069; GLUCOSYLCERAMIDASE; 1.
DR PANTHER; PTHR11069:SF23; LYSOSOMAL ACID GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF02055; Glyco_hydro_30; 1.
DR Pfam; PF17189; Glyco_hydro_30C; 1.
DR PRINTS; PR00843; GLHYDRLASE30.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361188};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361188};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..486
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007179646"
FT DOMAIN 74..418
FT /note="Glycosyl hydrolase family 30 TIM-barrel"
FT /evidence="ECO:0000259|Pfam:PF02055"
FT DOMAIN 423..482
FT /note="Glycosyl hydrolase family 30 beta sandwich"
FT /evidence="ECO:0000259|Pfam:PF17189"
SQ SEQUENCE 486 AA; 54206 MW; 6DF6321958273640 CRC64;
MTRIFSSFLI VGLFWAAALS CTAQRQTEYK TVKILTTTGD RSQELVESTA GLLPAASYDR
ASIVISPSQR YQTVYGFGAA LTGSTCYNLM QMTPENRRAF LTQTFSPSQG LGSSYVRISI
GCSDFSLSEY TLCDKEGIEN FALTDEEKNY IIPILKEVLT INPQLKIIGS PWTAPRWMKV
NSLSDLTTHN QWTSGQLNPK FYSDYAEYFA KWIEAMRDNG IAITALTIQN EPLNRGNSAS
MYMGWEEQRD FIKQALGKTL QQHNLATKVY LFDHNYNYDG IESQKNYPTR ILEDAEAAKY
VAGSAFHNYG GSADEITRVK NAFPDKEVIF TETSIGTWND GRNLSRRLTE DMEELGLRTL
QNGCSAVLVW NLMLDEKGAP NREGGCKTCF GAVDIASNGY TQITRNSHYF VIGHLSAVIK
PEAVRIGVKY QNMPTVQCLA FENPDKSIGV VLINKEKESH TLTLQVGNSK TTQTIPANAV
VSLLIR
//
