ID A0A125Y214_AERCA Unreviewed; 163 AA.
AC A0A125Y214;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Type II secretion system protein M {ECO:0000256|PIRNR:PIRNR006291};
DE Short=T2SS protein M {ECO:0000256|PIRNR:PIRNR006291};
DE AltName: Full=General secretion pathway protein M {ECO:0000256|PIRNR:PIRNR006291};
GN Name=gspM {ECO:0000313|EMBL:AXB05543.1};
GN Synonyms=exeM {ECO:0000313|EMBL:AXB05543.1};
GN ORFNames=C0708_14565 {ECO:0000313|EMBL:AXB09652.1}, C1C91_11580
GN {ECO:0000313|EMBL:AXB05543.1}, DN604_02200
GN {ECO:0000313|EMBL:RWT80199.1}, HED45_14950
GN {ECO:0000313|EMBL:NKD17376.1}, JC965_00535
GN {ECO:0000313|EMBL:QQA61070.1}, KAM348_26150
GN {ECO:0000313|EMBL:GJA55192.1}, KAM351_04350
GN {ECO:0000313|EMBL:GJA61824.1}, KAM379_29950
GN {ECO:0000313|EMBL:GJB73937.1}, N5I07_18890
GN {ECO:0000313|EMBL:MDH1899593.1}, N5I20_04280
GN {ECO:0000313|EMBL:MDH1504280.1}, WP5W18E02_05510
GN {ECO:0000313|EMBL:BBS15514.1};
OS Aeromonas caviae (Aeromonas punctata).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=648 {ECO:0000313|EMBL:RWT80199.1, ECO:0000313|Proteomes:UP000288891};
RN [1] {ECO:0000313|EMBL:RWT80199.1, ECO:0000313|Proteomes:UP000288891}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GEO_23_Down_B {ECO:0000313|EMBL:RWT80199.1,
RC ECO:0000313|Proteomes:UP000288891};
RA Mathys D.A., Mollenkopf D.F., Feicht S.M., Adams R.J., Albers A.L.,
RA Stuever D.M., Daniels J.B., Wittum T.E.;
RT "Carbapenemase-producing Enterobacteriaceae present in wastewater treatment
RT plant effluent and nearby surface waters in the US.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000266772, ECO:0000313|Proteomes:UP000266778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R25-2 {ECO:0000313|Proteomes:UP000266772}, and T25-39
RC {ECO:0000313|Proteomes:UP000266778};
RA Shi Y., Tian Z., Leclercq S.O., Zhang H., Yang M., Zhang Y.;
RT "Genetic characterization and potential molecular dissemination mechanism
RT of tet (31) gene in Aeromonas caviae from an oxytetracycline wastewater
RT treatment system.";
RL J Environ 76:259-266(2019).
RN [3] {ECO:0000313|EMBL:AXB05543.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=R25-2 {ECO:0000313|EMBL:AXB09652.1}, and T25-39
RC {ECO:0000313|EMBL:AXB05543.1};
RX PubMed=30528016; DOI=10.3791/1549;
RA Shi Y., Tian Z., Leclercq S.O., Zhang H., Yang M., Zhang Y.;
RT "Genetic characterization and potential molecular dissemination mechanism
RT of tet (31) gene in Aeromonas caviae from an oxytetracycline wastewater
RT treatment system.";
RL J Environ 76:259-266(2019).
RN [4] {ECO:0000313|EMBL:BBS15514.1, ECO:0000313|Proteomes:UP000515385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WP5-W18-ESBL-02 {ECO:0000313|EMBL:BBS15514.1,
RC ECO:0000313|Proteomes:UP000515385};
RA Sekizuka T., Itokawa K., Yatsu K., Inamine Y., Kuroda M.;
RT "complete genome sequences of Aeromonas caviae str. WP5-W18-ESBL-02
RT isolated from wastewater treatment plant effluent.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:NKD17376.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UFMG-H8 {ECO:0000313|EMBL:NKD17376.1};
RA Giannattasio-Ferraz S., Maskeri L., Penido A., Barbosa-Stancioli E.F.,
RA Putonti C.;
RT "Bacterial samples isolated from urine from healthy bovine heifers (Gyr
RT breed).";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QQA61070.1, ECO:0000313|Proteomes:UP000595994}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Aero21 {ECO:0000313|EMBL:QQA61070.1,
RC ECO:0000313|Proteomes:UP000595994};
RA Conte D., Mesa D., Palmeiro J.K., Dalla-Costa L.M.;
RT "GES Beta-lactamases isolated from hospital effluents in Brazil.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:GJA55192.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KAM348 {ECO:0000313|EMBL:GJA55192.1}, KAM351
RC {ECO:0000313|EMBL:GJA61824.1}, and KAM379
RC {ECO:0000313|EMBL:GJB73937.1};
RA Maehana S., Suzuki M., Kitasato H.;
RT "Draft genome sequence of carbapenem-resistant Aeromonas spp. in Japan.";
RL Submitted (JUL-2021) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:MDH1504280.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GD03710 {ECO:0000313|EMBL:MDH1504280.1}, and GD03796
RC {ECO:0000313|EMBL:MDH1899593.1};
RA Diorio-Toth L.;
RT "Intensive care unit water sources are persistently colonized with multi-
RT drug resistant bacteria and are the site of extensive horizontal gene
RT transfer of antibiotic resistance genes.";
RL Submitted (SEP-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inner membrane component of the type II secretion system
CC required for the energy-dependent secretion of extracellular factors
CC such as proteases and toxins from the periplasm.
CC {ECO:0000256|PIRNR:PIRNR006291}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004377}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004377}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the GSP M family.
CC {ECO:0000256|ARBA:ARBA00010637, ECO:0000256|PIRNR:PIRNR006291}.
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DR EMBL; CP025706; AXB05543.1; -; Genomic_DNA.
DR EMBL; CP025777; AXB09652.1; -; Genomic_DNA.
DR EMBL; AP022110; BBS15514.1; -; Genomic_DNA.
DR EMBL; BPNL01000029; GJA55192.1; -; Genomic_DNA.
DR EMBL; BPNN01000004; GJA61824.1; -; Genomic_DNA.
DR EMBL; BPOM01000026; GJB73937.1; -; Genomic_DNA.
DR EMBL; JAOCIZ010000011; MDH1504280.1; -; Genomic_DNA.
DR EMBL; JAOCFT010000001; MDH1899593.1; -; Genomic_DNA.
DR EMBL; JAAVMO010000007; NKD17376.1; -; Genomic_DNA.
DR EMBL; CP065937; QQA61070.1; -; Genomic_DNA.
DR EMBL; QKPH01000004; RWT80199.1; -; Genomic_DNA.
DR RefSeq; WP_010675717.1; NZ_WUTZ01000003.1.
DR OrthoDB; 6624834at2; -.
DR Proteomes; UP000266772; Chromosome.
DR Proteomes; UP000266778; Chromosome.
DR Proteomes; UP000288891; Unassembled WGS sequence.
DR Proteomes; UP000515385; Chromosome.
DR Proteomes; UP000595994; Chromosome.
DR Proteomes; UP000705611; Unassembled WGS sequence.
DR Proteomes; UP000886934; Unassembled WGS sequence.
DR Proteomes; UP000887009; Unassembled WGS sequence.
DR Proteomes; UP000887145; Unassembled WGS sequence.
DR Proteomes; UP001160758; Unassembled WGS sequence.
DR Proteomes; UP001161704; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR Gene3D; 3.30.1360.100; General secretion pathway protein M, EpsM; 1.
DR InterPro; IPR007690; T2SS_GspM.
DR InterPro; IPR023229; T2SS_M_periplasmic_sf.
DR Pfam; PF04612; T2SSM; 1.
DR PIRSF; PIRSF006291; GspM; 1.
DR SUPFAM; SSF103054; General secretion pathway protein M, EpsM; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|PIRNR:PIRNR006291};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR006291};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR006291};
KW Protein transport {ECO:0000256|PIRNR:PIRNR006291};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|PIRNR:PIRNR006291}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 163 AA; 18489 MW; 9D3D3F4E6D665CD7 CRC64;
MMDKLQSWWR GISAREQRLV AVGGSVLLIG LFYWAIWQPV ANRIAERERQ VVNQQQTLAW
LKEKGQEVLA MQGGQGRQID TGGTLDGVVN RTAFNQKIKI ARLQPQGQEL QVWIDTVPFD
DLLIWLATLS DQYGVQVQII ELAREGLAPG LVKVRRLQLS RSQ
//
