ID A0A125YRL2_TOXGV Unreviewed; 981 AA.
AC A0A125YRL2; A0A0F7V5G1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Magnesium transporter NIPA {ECO:0000313|EMBL:ESS35351.1};
GN ORFNames=BN1205_100560 {ECO:0000313|EMBL:CEL77746.1}, TGVEG_315440
GN {ECO:0000313|EMBL:ESS35351.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS35351.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS35351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS35351.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS35351.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS35351.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL77746.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL77746.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LN714501; CEL77746.1; -; Genomic_DNA.
DR EMBL; AAYL02000034; ESS35351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A125YRL2; -.
DR PaxDb; 5811-TGME49_115440; -.
DR EnsemblProtists; ESS35351; ESS35351; TGVEG_315440.
DR VEuPathDB; ToxoDB:TGVEG_315440; -.
DR eggNOG; KOG4726; Eukaryota.
DR OMA; LPQHYIG; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF9; MAGNESIUM TRANSPORTER NIPA8-RELATED; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 39..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 108872 MW; 3C845D5E19882515 CRC64;
MWQLGIAFAA VASFCGAAGD ALVRLSFVVE RKRLASYRRE ERRRAKGGNE EEAKPNKTGG
AVRTNHSRAE KSRSTREKKQ SISCLQDPAS TRFSPGKKTE LADKRETFET SEKCQRGDDR
RETPNVLGRG KKGVIQKLTD CSATGRRPLY LRPLWIIGTC LGTVINSLLS IISLDFATAA
IVTPFAGLHI FWNVILSRFV LQEQVLPQHY IGSALILLGL LLVLCFGVHT PPPLSLEQLL
RLYSQNTCVF YFFLSILCIS FCIFVALVGR DFPESVSHSP FSSVTSCRSP AHSKRRTLEL
HVLAGPALSF SSPIPSLFAS QNETDRKKTS SASCPSPRDH KPVASSVYVA SDVEDRSLAP
PLSSFLFSPP SLPFSGQRHL RGLFAVGGKR ETSFSEGEED SRWGEEDSRE RKDQRFPPKR
PRETGDSLVL QGDTMQMHPT EVFQGEKTVR TSSCGRHDSH RHSQEIFGAR ELCVTVPAST
VKDDEEWRGT EEDYVRRVGR RRKPGSCRAL ITNEGRLFSS HPLFFNPAFR RFSTAAVSGL
CGGNTNVLME HVMKVWHEET WENLFHYKFF ILLLLLGGMA VGQLLFLNVG LARYEALYVV
PTTMSVLIVS SCFAEIALFI NVLHMPQTEF LLFAGGCFSI VVGIMILSSA SVERFEAREA
RADNKGVSVD VEEVEFSSVC SSSVDSTSGR LNDGEDDSVP QEFRQVFAAL EMETEVHAQT
AYRHHTVSFP APDTLYDLPH REKTDGGGDR QETACNQEGN ADRRRKDAEK KQINEKGRAR
DTQRLKNELE GQAHRSTTKP PGQGIEGERG EQIYGTSSLL SHRFLPPAWT LRFSLSSERR
RKAKGYVYLS DVPPLPEGVG CFGYQQVSAE NSTRAVSSAS LEASSFSESS QQGAEGENNR
DHSFPRFPQD TQGVNPHLIA ASETLREYAH HRHAVCCLHE RDPRPKSAAL SENSSDPDRE
ASSVSGRDSS SVSERESSSV S
//
