ID A0A125YWU4_TOXGV Unreviewed; 1049 AA.
AC A0A125YWU4; A0A0F7V772;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=BN1205_030920 {ECO:0000313|EMBL:CEL77078.1}, TGVEG_214970
GN {ECO:0000313|EMBL:ESS31152.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS31152.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS31152.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS31152.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS31152.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS31152.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL77078.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL77078.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; LN714500; CEL77078.1; -; Genomic_DNA.
DR EMBL; AAYL02000202; ESS31152.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A125YWU4; -.
DR STRING; 432359.A0A125YWU4; -.
DR PaxDb; 5811-TGME49_014970; -.
DR EnsemblProtists; ESS31152; ESS31152; TGVEG_214970.
DR VEuPathDB; ToxoDB:TGVEG_214970; -.
DR eggNOG; KOG0477; Eukaryota.
DR OMA; LKDWPYS; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 2.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 535..792
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 117271 MW; DC2D431CC4A72870 CRC64;
MSTNRASGLD RSPLRRTEED SEADVNADGE RGVVLSEVEE EDDQGRLRGG VLDENVDYFQ
GSRELDLEER RAEEEAEKII DEENTEDLVF GMRDDERERE AFLAAGMDAD AFDASLIDDE
DLDDLDPHLE EKARRAAERH LDARENEARR KRRGDKAAKG DIWAQLLEED DEGASEMDRV
LRRVEERRRR FFSGTGMGGR GSEQINLHDL NEAKKLLTES NPALVPFGEQ HQQAMDTLFK
YFLYKFNLHA FRRVQHGGVG EEEEGEKRDD EKALYYLDRI QDMIREDRAT ILVDTRHLIF
FSDQLVKWIE AYPLPALQVM NDVITVEAEA SCPSLYSTRI CSVILTDWPY KEELRQLRCT
HLNSLISVSG VVTRRSSVLP KMRLLYLKCS NCLNSITDVP IQLVEGRKND AMPRKCPHCQ
GSRFIIDRVR TAFVDFQRLT LQESPGKVPP GRPPRQREVI ITGELVDSIK PGEEVDVLGI
YQTKCDYSLN AKTGFPILAT EILANNVVRT SDARMTEFTE EDLKAIKQLS RDPHIRERIL
ASIAPALWGN REVKTAIAYA LFGGVPKGRG PSERGQDGND LPGSLLMGSS RRTAWGKGAS
DAAQGIGARE EGGSQGGTLG SSPHTIRGDI NVLLLGDPGL GKSQALQYVA RTFPRTVCTT
GKGASAVGLT AGVRKDPQTG EWTLEGGALV LADEGICLID EFDKMVDRDR VSIHEAMEQQ
SISISKAGIV TTLRARCSVI AAANPKFGRY IPSYTFKENV DLSDPILSRF DIIAVLRDVP
DADEDHYLAE YVLTHHQLAH PNISHLENYQ QRMEELEHIM LGNQAYEPIP QDLLQKYILY
ARANCRPVLD PSVNSVAAKV SSFYARLRRR AAATGGLPLT LRHVEALLRM AEANAKMRLS
PVVSSTDVDY AIATLLDSFI SSQKFAVQQR LGREFARYRA LARGGWATLS ALLRRLMQQR
LQRVMLQRAG APGAELEPLS QADFDSARRV KVPEFVKVAA QNKFAAYQVE AWMASSHFTE
QFRVVQEGED KTIVSLNWSR PTAAAEGSG
//
