ID A0A126RIE8_9SPHN Unreviewed; 1057 AA.
AC A0A126RIE8;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=K426_04475 {ECO:0000313|EMBL:AMK21852.1};
OS Sphingobium sp. TKS.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingobium.
OX NCBI_TaxID=1315974 {ECO:0000313|EMBL:AMK21852.1, ECO:0000313|Proteomes:UP000060779};
RN [1] {ECO:0000313|Proteomes:UP000060779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TKS {ECO:0000313|Proteomes:UP000060779};
RA Tabata M.;
RT "Whole genome sequence of gamma-HCH degrading bacterium Sphingobium sp.
RT TKS.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AMK21852.1, ECO:0000313|Proteomes:UP000060779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TKS {ECO:0000313|EMBL:AMK21852.1,
RC ECO:0000313|Proteomes:UP000060779};
RX PubMed=27056231;
RA Tabata M., Ohhata S., Kawasumi T., Nikawadori Y., Kishida K., Sato T.,
RA Ohtsubo Y., Tsuda M., Nagata Y.;
RT "Complete Genome Sequence of a gamma-Hexachlorocyclohexane Degrader,
RT Sphingobium sp. Strain TKS, Isolated from a gamma-Hexachlorocyclohexane-
RT Degrading Microbial Community.";
RL Genome Announc. 4:0-0(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP005083; AMK21852.1; -; Genomic_DNA.
DR RefSeq; WP_066554265.1; NZ_CP005083.1.
DR AlphaFoldDB; A0A126RIE8; -.
DR STRING; 1315974.K426_04475; -.
DR KEGG; spht:K426_04475; -.
DR PATRIC; fig|1315974.3.peg.937; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000060779; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000060779}.
FT DOMAIN 1..415
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 416..701
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 9..16
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1057 AA; 115052 MW; B607FF46010FA365 CRC64;
MTELSIVPAG AGAGKTHHIQ ETLTQWVRDG KVRPEKILAV TFTEAAAGEL RQRIRGALIA
DSNLSAALAV ERAYVSTIHG LGRRLLIEHA FASGSSPQQR LIAEDEQDLL IRRSIEENPA
LSELSRNLAA LGYQGSFSSD QTAEDSFRKK LLGVIALLRT LGPRGSDPAM ADFVEASIRT
GYGAPIGKSE TLAAALQKTV DALLQAFPRS LADDAGSATA KTAFRENFRA LKQAQQLLAS
GGTDWRLWQK LRGLRLSMRG NPTPDGYDDL ASAVMLAADN LVFHPGPLED AVSHARALVE
GAQSAMTDYE TRKRELGVID FSDMVTNAAR ILDEKPAVLG AIMDEVDCVI VDEFQDTNPI
QFTFLWALAR KAKRALIVGD TKQAIMGFQG ADPRLTIALT QQFETSPLDR NWRSDPRIMA
FMNALGPCLF GEDYTALAAQ NASGHDTALE VIGLANKRGA RSGGKPQHFI ADRLLSLLTD
DRVTIVDRHS KALRDLEPRD VAILCPTHSH CASYAAALRA LGLPVRVAEG GWWQSKIVQA
ACFALRFAVD PADNHAAICT ATLGPGATPL GDALGALARD GRIETPELMA LQGLWPDSLA
TPVDRLVHRV IQVAGLRDWC DRLDDPAQMR ADLLRFEAEA AAFLDAHRDM REASGFYGQS
ANVFLGWLEN KVGLKGEDLR PNPAGAEADG IEIVTWHASK GREWPVVVVC GLDHKLDPRA
GTFSTKFPDF DDLDHVIEQA TLAYAPDFAA PEATARFLDG LYPECEETAR RLLYVALTRA
RNRLIIEWPQ DDDKVEPPLP ITARRLLNDG CGIKLQGNQI TVGAAHFPSR MTICGKEIPA
SFDREDRVRL ESNDREPRFA IERRAIGLIT PVISPSQAMA TTRPLPLQIE TRPISAGVRL
TGSDLAQATD KGTAVHEALR ILLCRPDLRH RVGQHCRIAV AEVELLAQQA QALRQTLTEL
GYSRLHIEQP IDIALSDGGR QIIILDLIAE GPNGIIIVDH KSGAVADHAK RFESYWPQLA
AYIDAVGTKG EKAVDGAAVF WTETGELTIG RDCLPNA
//
