ID A0A126V4N8_9RHOB Unreviewed; 787 AA.
AC A0A126V4N8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=RC74_20245 {ECO:0000313|EMBL:AML53274.1};
OS Falsihalocynthiibacter arcticus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Falsihalocynthiibacter.
OX NCBI_TaxID=1579316 {ECO:0000313|EMBL:AML53274.1, ECO:0000313|Proteomes:UP000070371};
RN [1] {ECO:0000313|EMBL:AML53274.1, ECO:0000313|Proteomes:UP000070371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAMC 20958 {ECO:0000313|EMBL:AML53274.1};
RA Lee Y.M., Baek K., Lee H.K., Shin S.C.;
RT "Complete genome sequence of Halocynthiibacter arcticus PAMC 20958t from
RT arctic marine sediment.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP014327; AML53274.1; -; Genomic_DNA.
DR RefSeq; WP_039001309.1; NZ_CP014327.1.
DR AlphaFoldDB; A0A126V4N8; -.
DR STRING; 1579316.RC74_20245; -.
DR KEGG; hat:RC74_20245; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000070371; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000070371}.
FT DOMAIN 32..312
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 313..587
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 53..60
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 787 AA; 88069 MW; 750747CEDDF3B19B CRC64;
MSSFDENDAF EAASRPSLAA RAMAARPAPY LDELNPAQRE AVETMDGPVL MLAGAGTGKT
KALTSRIVHL LNTGRARPNE ILAVTFTNKA AREMKLRVGR MLGQTIEGMP WLGTFHSVCV
KLLRRHAELV GLKSNFTILD TDDQIRLLKQ LLTAEKIDDK RWPARQLAGI IDGWKNRAWT
PKQVSSAEAG AFDGKGIELY AQYQTRLREL NACDFGDLLM HVVTIFQKHS DILEQYQRWF
KYILVDEYQD TNVAQYLWLR LLASGHKNIC CVGDDDQSIY GWRGAEVGNI LRFEQDFPGA
HVVRLEQNYR STPHILAAAS GVISGNAGRL GKELWTDLPD GEKVRLIGHW DGEEEARWIG
EELESLQRGR RTEKGQSLET MAILVRASHQ MRAFEDRFLT IGLPYRVIGG PRFYERLEIR
DAMAYFRVVT SPDDDLAFER IVNTPKRGLG NVAQQKIQLC ARKHEVSLLE GAKHLLAENG
IGGKGGTELR KLVEGFDRWI AEARSERLSH MELAEIILDE SGYTGHWQND KTPEGPGRLE
NLKELVKALE QFENLQGFLE HVSLIMDNEN EESEEKVTIM TLHGAKGLEF PNVFLPGWED
GLFPSQRSMD ESGVKGEEEE RRLAYVGITR AERLCTISFA ANRRVYGQWQ NALPSRFIDE
LPEEHVDVLT PPGLYGGGYG AAAGGAPQME ARATKADAYN SPGWKRMQAR ANERPTGNPR
SSRHLTIDAS AISSFTEGER VFNQKYGYGV IVEVDNDKLG ISFDKAGDKK VLASFVVPAD
KAGDVPF
//
