ID   A0A127B194_9BACT        Unreviewed;       473 AA.
AC   A0A127B194;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Sodium/alanine symporter {ECO:0000313|EMBL:AMM51047.1};
GN   ORFNames=TH61_07425 {ECO:0000313|EMBL:AMM51047.1};
OS   Rufibacter sp. DG15C.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
OC   Rufibacter.
OX   NCBI_TaxID=1379909 {ECO:0000313|EMBL:AMM51047.1, ECO:0000313|Proteomes:UP000070672};
RN   [1] {ECO:0000313|EMBL:AMM51047.1, ECO:0000313|Proteomes:UP000070672}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG15C {ECO:0000313|EMBL:AMM51047.1,
RC   ECO:0000313|Proteomes:UP000070672};
RA   Kim M.K., Srinivasan S., Lee J.-J.;
RT   "Rufibacter sp. DG15C whole genome sequencing.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363064};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363064}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the alanine or glycine:cation symporter (AGCS)
CC       (TC 2.A.25) family. {ECO:0000256|ARBA:ARBA00009261,
CC       ECO:0000256|RuleBase:RU363064}.
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DR   EMBL; CP010776; AMM51047.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A127B194; -.
DR   STRING; 1379909.TH61_07425; -.
DR   KEGG; rud:TH61_07425; -.
DR   PATRIC; fig|1379909.4.peg.1598; -.
DR   Proteomes; UP000070672; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005283; F:amino acid:sodium symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR001463; Na/Ala_symport.
DR   NCBIfam; TIGR00835; agcS; 1.
DR   PANTHER; PTHR30330; AGSS FAMILY TRANSPORTER, SODIUM-ALANINE; 1.
DR   PANTHER; PTHR30330:SF3; TRANSCRIPTIONAL REGULATOR, LRP FAMILY-RELATED; 1.
DR   Pfam; PF01235; Na_Ala_symp; 1.
DR   PRINTS; PR00175; NAALASMPORT.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU363064};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363064};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070672};
KW   Symport {ECO:0000256|RuleBase:RU363064};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363064};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363064}.
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        98..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        149..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        190..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        249..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        314..334
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        359..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        398..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
FT   TRANSMEM        422..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363064"
SQ   SEQUENCE   473 AA;  51108 MW;  6E07450CD62BCD36 CRC64;
     MQKIDAFLAE ASSLAWGMPL LILLMGGGLF LMLYSRLVPF RMLKHSIAVI RGKYQDPNAA
     GQITPFEAMA GALASTIGMG SISGVAVGIA MGGPGVLFWM WISALVGMAT KFFTCTLAIM
     YRGRNELGEV EGGPMYIVTE GLGKKWKPLS ILFAGAGLFG TLPLFQANQL TQILTDVLLK
     PSGVVGEENL FVSNLLMGMA FAFLVSIILF GGLKRIAAVA TKLVPFMVVL FSGSVIYIVF
     SNLEAVPGMF ALIFEDAFTG KAVLGGSVIQ IIIMGARRAS FSNEAGIGTA DMMHGESRNN
     EPVREGLVAM WEPFIDTIVV CTMTGLAILV TGVWDTNTGN GVSMTSEAFG AAMPHVGKYL
     LVICVFIFAF TALFSYCYYG SKCFTYLFGF KYRRFYDYFY ILTIIIGSVV TLTSVINLVD
     TAFALMAIPT MTCALVLAPK VLAASSEYLG RLQRGEIEEF EQKQVVPTKK QKA
//