ID A0A127VCM2_9SPHI Unreviewed; 2629 AA.
AC A0A127VCM2;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Nonribosomal peptide synthetase {ECO:0000313|EMBL:AMP99113.1};
GN ORFNames=AY601_2216 {ECO:0000313|EMBL:AMP99113.1};
OS Pedobacter cryoconitis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=188932 {ECO:0000313|EMBL:AMP99113.1, ECO:0000313|Proteomes:UP000071561};
RN [1] {ECO:0000313|EMBL:AMP99113.1, ECO:0000313|Proteomes:UP000071561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAMC 27485 {ECO:0000313|EMBL:AMP99113.1,
RC ECO:0000313|Proteomes:UP000071561};
RA Lee J., Kim O.-S.;
RT "Complete genome sequence of Pedobacter cryoconitis PAMC 27485.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP014504; AMP99113.1; -; Genomic_DNA.
DR RefSeq; WP_068400584.1; NZ_CP014504.1.
DR KEGG; pcm:AY601_2216; -.
DR PATRIC; fig|188932.3.peg.2321; -.
DR OrthoDB; 4317020at2; -.
DR Proteomes; UP000071561; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 1.10.10.1830; Non-ribosomal peptide synthase, adenylation domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR041464; TubC_N.
DR InterPro; IPR044894; TubC_N_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF18563; TubC_N; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000071561}.
FT DOMAIN 1027..1101
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2537..2612
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1001..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2629 AA; 297960 MW; F8F52F1269D1D55B CRC64;
MEFFLKQLSE KKIKLSVIND DLQIEAPKGT VTPELLKEIK LNKEAILLNL KSSLAKKYYA
GIPKTAISSS YPLAHSQKRF WISENLEAKA STHLISGAFL LKGALDAGKL ENSFHVLVQR
HEILRTIFLK DKDGNACQQV IPFHAANYQL ELADFSAAKD PAAASKNKIE ERIKDKFQLD
QLPLIRIGLF SLADNQWHLY FSMHHIISDG WSMEILIREL IFGYRDIETF STLPALNIQY
KDFADWQLKY LASENGTQSR EYWKKTFENG IPLFDLPSQY SRPAVQSNQG KIESRELQTD
FVEKLIAYAQ LNQCSLFNVL FAGVSVLLYR YTAQREFVLG TPVAGRNHVE LENQIGPYLN
LLPLKVDIDP EKSFSGILKE IKASTNITFE HQYYPFDLIV ENLGIKKELS RSPLFDIMVS
LREDFMHQTK ELNFEDELTI TAMGITHDVS RLDIIFNFAK KADHLVLNIE YRTDLFEHSF
ILQLAAHLIT LLSGLIEKDH LPVSRINYLT PVKEQDSAIA NIPVATLALL DAQKEVSAEN
IAVSHGEEQL TYHQLYQLAD QFGTYLKEYG EVKKGDFVAI SLPHSIPAIW SFLSVLRIGA
VYVPVDPGYP ASRIDYILKD CNSKFLINEE IIHQFLSTRA TYLPGKPEAV GMTDLAYVIY
TSGTTGNPKG VLLTHQNLSR HTQVILGHIK DFPDQIKMLN HASYSFDISL FEILPPLLSG
GELIIINRFD ILGGENQMAI LSKTTHIQII PSFLEQLIGS VPEQDRIKAF TAIRHIHIGG
DAVQTLHLLN IKKYFEHAVI HELYGPTETT IWCTKKTYPV GPDDQQHLNG KIIGQPVTGY
IVYILDDYLQ TVPDWVCGEL YIGGDGVASG YLNKEELTAK QFIPNPFEKG GRLYKTGDLV
RRLRNGDLEF LGRKDEQVKI RGYRIELGEV EHAILSSPEV NDAVLVVKTS ETGDKELVAY
IVSDKQPDIY ELRRHLLEIL PRYMLPSHFV ALTELPLTPN GKVDKKALPD PDNSTLPDDA
HNPSFVDART AQERILISVW EDVLKKNRIG IRDDFYNSGG DSIKSIQIVS RLKQKGYQLK
IEHVLGFPVL ERMAGFMNQE ETIADQSVIL GPVVMTPVQH YFFSQKLNNY QHYNQSVVLK
STQRLDTALL RKCMVELANH HDALRMVFKK QNDKWEQFNQ DVYGDNFTIL YTDLREHENG
VAEMGTIAEK LQAGFQLETG PLITAGHFSL NDGDRVVLII HHLVVDGMSW RILLEDLALL
YSSYIKSENH VLPLKTDSFQ RWAFLLQEMA RSEQFEPEKE YWEQVLNQFV MPFPKDIDTA
QSARIDRHIT FSLDRSITEI LKSGVHHAYN TEINDILLSC LAIAIKKVFG IAKSRVKMEG
HGREQILQDA DISRTVGWFT TMYPYVLAVS GSTHAQDSLV KVKEDLRRIP NKGIGYGMLN
YLRDDFHHPM DAAVLFNYLG DFDNTLPEDK DSALEFSSEY IGRNNMEEAT DDILLSVSGM
LVAGELTMSL GYASNTYHAH TIERLSASYK EALIGLIDHL ANTLQPKVTP WDLTFKDLSM
EELAEINKDN NVEDIYSLSP LQQGIYYHCL ADQFSPMYFE QMSYRIKAPG LNIESVRKAY
DKLVERHGVL RTGFRNDLRE EPLQIVWKYA PSNFTFKEIP AGIPAAAFIE QEKLNDRELG
FNLESSSQMR LLVIAHGNED YEFIWSNHHI IIDGWCMGVL IKDFYQLLNA LDHNLPPDLP
TPVPYSGYIS WLNQIDEQKS RRYWENYLSG YTKIAGVPYQ KTAVAQPVYQ QAKQILKIEG
DAYTQLQSFC NELGITQNTF IQGAWGYLLS RYNDVEDVVF GAVVSGRPAS LSGVEDMVGL
FINTIPVRVN YQDIETPAEL LKKLNREAIT GNEHHYINLS EIQSVSELKA QLINHIMIFE
NYPIADLLKE DLELKNENQE LSIIAADAFE QTNYDLNVVV VPLENTLSIQ FKYNSNIYLE
KGMQELTGHL ESIISQFANN PNSSLDAIAL LAEDEKYQLI EQFNNTQKLF HQNKRITDLF
EEQVKINPDG IALITADGDF TFSALNLLRQ SYSAYFVHTL KIKTGDRMLI SLTHDQHLVA
VLLAVNKIGA VSVPVDPVTP AERIAFIYKD SDSAALIDTN TLALADLKNS ANPVQDTLLI
LTEDPGFIIY TSGSTGLPKG VLLTASGLMN RLNWMWEAYP FQKGEVCCAK TSISFVDHIC
ELFGPLLKGI PLVLYPREQL LDIKYFINSL HTHKITRLLL VPSLLKAMLS YPALFKDKLQ
NICLWSCSGE ELKLQLVQQF YDTVQNENAH LINIYGSTEV TADATYYDTI AYNNADVIVS
SSDSVPIGKP IANSKIYILD QWLRPLPIGV PGEICISGTV VSSGYLHQEQ GEDKFVRSPF
EPSAFLYKTG DLGKWMPDGN LVYSGRKDNQ VKIRGHRIEL AEIEYSVLKN EQITDAVVLA
IKEQGTDEIE LAVYFTSNTE TDPSEIKQFL KDALPDYMIP AYFFQVEEIP LNTNGKVDKH
ALAQLKNTEI TGKTYVAPGN DIQVRLVKIW ESVLKKDKIS ITANFFELGG HSIKAMNILS
KINKEFNLDM NIKNVFHYPV IEDLSVFIDF IQKQKEVRAK GAAFREIDL
//
