ID A0A131ZVC4_SARSC Unreviewed; 330 AA.
AC A0A131ZVC4;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=STE20-related kinase adaptor beta-like protein {ECO:0000313|EMBL:KPM02756.1};
GN ORFNames=QR98_0011750 {ECO:0000313|EMBL:KPM02756.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM02756.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM02756.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM02756.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
CC -!- FUNCTION: Pseudokinase which, in complex with CAB39/MO25
CC (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates
CC STK11/LKB1. Adopts a closed conformation typical of active protein
CC kinases and binds STK11/LKB1 as a pseudosubstrate, promoting
CC conformational change of STK11/LKB1 in an active conformation.
CC {ECO:0000256|ARBA:ARBA00034653}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM02756.1}.
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DR EMBL; JXLN01002806; KPM02756.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A131ZVC4; -.
DR VEuPathDB; VectorBase:SSCA003809; -.
DR OMA; YDTHLQN; -.
DR OrthoDB; 5389025at2759; -.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR047173; STRAD_A/B-like.
DR PANTHER; PTHR48014; SERINE/THREONINE-PROTEIN KINASE FRAY2; 1.
DR PANTHER; PTHR48014:SF24; SERINE_THREONINE-PROTEIN KINASE FRAY2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:KPM02756.1};
KW Transferase {ECO:0000313|EMBL:KPM02756.1}.
SQ SEQUENCE 330 AA; 38450 MW; 2F88F233BC2A3372 CRC64;
MNRLLTLSKS NFTKNVEDYS IENHLNPDQT LWKAKNRSLN VQCVLRKINL IDVDLELLEN
ESNLDEIVDH PNIINMIENF VQKDYLYTIF PFANYGSIDK LCKPYGLEEG IIALVMKDLL
PALDYLHRNN IIHRAIKGSN ILIFGDAETS FKFTLSGLKH SFLDDSTSFL NIFDYPTTSS
KLLNHLAPEI LEQNILGYNY KSDIHSVGIL CCELANGIIP FDNISTDELL FYKLIGDTPR
LLDHSCDEMN IFQELIDRLE ISLKQRYRIY MKKRFSSAFH DFVQQCLHCE PINRPKAYEL
MEHTFCSLNK SETESYDRFK EILKKKFHSQ
//
