ID A0A131ZWG5_SARSC Unreviewed; 3105 AA.
AC A0A131ZWG5;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Polycystic kidney disease protein 1-like protein 2-like protein {ECO:0000313|EMBL:KPM02869.1};
GN ORFNames=QR98_0012930 {ECO:0000313|EMBL:KPM02869.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM02869.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM02869.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM02869.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM02869.1}.
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DR EMBL; JXLN01003190; KPM02869.1; -; Genomic_DNA.
DR VEuPathDB; VectorBase:SSCA004614; -.
DR OMA; VQRTACC; -.
DR OrthoDB; 5401608at2759; -.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00801; PKD; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00089; PKD; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50093; PKD; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 532..594
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2017..2136
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
SQ SEQUENCE 3105 AA; 357194 MW; 90D883B138B1095C CRC64;
MLKLLIKLDS ILLVNLFVCG ILSLDQVRGG HHQQQQFNDG DCLDYRSFNH FRYSPNANYD
PNKGINGSEC ARICSESNLP HAGLVSQKYC LCASPEDFQS IRSIPKVSNH LCDEGDLYLR
YFRGEPIGQI DELTIALRKK IHLVDDEVYF DLKSIANGPI EYSIDFGDGN DRIEWNPART
YKHRYHLADK YLVQVQARLV EKPNIRIKQT HQLRIHSKIR NDSVKVSCPK IAEPDDRIDC
DITITIGTLM QMLIDFGDGY QSKMINLPDV PMRSLGINMP LKNSSNLIDQ DDRLSSSQMV
AFPFEEKSFS LLGAIVAIEG FAIKSGRLFV HILRKVCDEC VDNVFSCFEP NALCSVSKTC
SGDCQPFNEQ SIKYLIVKTF DITIKEGPFY LKSQSSFRML SDDLIAFRTQ GASLGYRRPK
SIEVPDYRYR FDDTNQNISE FYSSKFQKLS DRKHFLRLIV SEPLMFSMTH SYNQSGQYQI
KFMVKNEFDD DQINRIQAIN VQSTISKMRL TVKPTSVAVG KNVNVVVQLS KGSNIELQWD
FGDGNRSIEH IELIQTNKKF LRTYNYSRPG IYKIIIMAAN LQGNTTAEQE LIVEHPVLKH
WKIISNSPVL LPDVVKFSIS YPKDYVLPTN ATIQLNFGDG QRDHWSIPDQ NWKGLHEIEH
LYEKSGMYNI DVDIYNIVSK LKRRFQIEVM TKIMGLRYLI KSMRSDQVLI EIDDSIKLAS
LNSTLNFQIE LDSGDVEHYL VYINDELHTK TIDKSLNITF TEAGLFNVSV YGYNHIQNLS
RPYTKLIKVF EPVSGLEILD TSDDTIDVET KFLTIRIETI GTNSCLLVDF GERSSKSEDF
FTFGDDENCM QQFSRFNPVH NTSLEKTIRL NRKYLKPNNY EITVVLANKI SKLTKKLSIT
VVEIDCKPPI IKIKNQIQNR KQADKIWRSK PVQLYSKTII DCNATFSTAR FWRAYLLNET
DGETKMFIDL TDLDSHDKSF LYVPAFHLQP GLYRFQFGIN MTSPYPHPLM PLFVSSSTYI
KIVPSPIIAL LTEGSQSRIL LKFAPITNSI DPDNYHNKNF TVKWFCRRLP DESISFAFSD
EQQNFSEPIY DRSNIDEEWG DDDLGGCFGK GPGRINLTTD QVEWNTTVFR KADETYELMI
KVIPNDREPS WGALQLTIVK SKPPSVMVVC QTKSLCYPHY PIGQTINPVR VGLEGQCTES
CDGQLIYRWE IFGVTNETDV HLTKASQYVA GIDQPKMALG INFFNEYYPK FKDFYIKLAV
TNENRLKGES DIFLHINQPP NGGECVLKYA NNRALLDRFI ARCSMWIDPE DKPIDYYGFW
IKNIETNIVS YLMYGPDKRV QLILPYGNFT VGVDIRDKEG ALTKVVMANV STILPSEDDY
EKLINSRILE NIDASGDQSL MNMMAQALSS LMNENFGQKL LNSTLSRRST TTTSTTTTTV
SYDYIDEDDL IREAQTKARI VKSVDAMMNA DTLFSLEQIG SALTALAGKG KSVDNEAKNL
IVKLLNKTVS IASRLQVESP QQLLDFCRFA IGTMGGIVNR MSEQIVSGIV LPTDRSKGWN
LDYNVEVPDV DDEPDYIMDA TTSIEEALNK AVIRSERRKT ELQIRQMIDL TIELILSILK
NIVVGEEKIE FAAPSGLVLT IAMYPRGSIS NQTIKHEDSI YVFPKVCDIL VGQKCLGNET
LGVLAVSWPS ILESFGNSVD LLSKDSKTLQ LLIINDKLEI LKIENSKRPF NIIVPRKNTQ
ESETNQQELM VEIVPKLRFY ESMIYHQVLI EKADSAMNIE LRKSNPQSEL LLYVKYREKP
AFDYYDLIIP LKSMKIIVSD QNSKETIYSI FLSNDIIKNR TGFFYIGVVE IDVEQLSNSN
ESTLLNGSIV FNQNKAFDDD DYNHTMTNYT LPGALREFST NYSLKIFTSG CYFYNYHRKI
WSAEGCKVFK ANYAMTHCKC NHLTSFGSGF FVMPNSIDFA YVFANAGFAD NVTIYMTIVI
TLGIYAILLI WTHRNDKEDL MKLGSTPLPD NDALSKYLYE IIVYTGDKDE AATDSKIFFI
LSGDDEETGV RCLTDPFQKA FKRADINSFV MAVPNKLGRL NYLRIWHDNT GQNKYRSWFL
SLIVIRDIQT GERYDFICNK WLAVEKDDGA IDRLLPVASP DEATEFTHLF HTQNNLADGH
LWFSIFMRPP RSRFTRVQRV SCCMALLYLS MLVNAMWYQR VPSRPSGSSL EFGPFSLSPE
QIGVGFMSNL IVFPMTFLII FCFRKARLRQ LRPSRITEAL RKQKVFLEEM RFNNDESLKQ
KKQKILEKGN YFDLQNEKIR PGDGSRRVIK KQSKRFTLPH YFRYIGWVLC IISIMVSIFF
LWAYGIQFGD EKTRKWITSL IISFFSSVLI TQPIKVFLTA IILAAIFKSP DVSIDDSDED
EDDIDLTLLD NDEYNYHSIK NENDDCHQKN FCRSQMYRSM NSNLLNKIKE QRLKEIKIII
ILKDIFSYMC FLWILIVIGY GNRDPSAYLM KETLVKTIIE DSINKINFMN IKTHKDIWDW
VDNTLITNLL IGDWYNGYKP LGLRGFMNDR VNRIRVKPNT CRPEIYLEKV IDRCRAFSNI
IYEDRMSYLQ GWQDPSKLSY VNESLPLSKK GFLNPSKSLK DEWNYRNAFE LDGISFLGKL
DIYSGGGYVI PLKGSRDELR KKIKDLVELN WIDERTRSVI AEFSVYNAQA NLFGIISCVN
EFQPGGGIIP TYRIDVVRLM RHHQSFGVFV IMCEIIFLFF IIYFTVRELK FWSQQGRSYL
QSYWNWAELF ILILSYLAIG LYIYRIILTN RILSVFHETH GNGYVKLQYV SLIDELFGYL
LAFLLFIAII KFIKLFRFNK RMGVLYSTLA QCSKDLKSFS IVFCIVFFAF VQMFYVLFGV
TMKQYSSFVN AAETTFGMVT GKFDFESMVI ASPLLGPVVF FVFVLCTSII LVNIFLTLII
SAFETVKHDV MKQDNEYEII DFILAKLKTL LGITTFPDFF DDTDLDEREK QAKLIEEQIE
SLPMKVEQLK SYVKKKNYRH RHNSAAGNHQ LKMVIDNDNN LEANGSKKLI QLDANDLQKR
DSIESLRNQR NRRNGRRSLK TTTVGLMTTG IISKTKFLDW NEVQD
//
