ID   A0A131ZZM4_SARSC        Unreviewed;       498 AA.
AC   A0A131ZZM4;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Forkhead domain-containing protein {ECO:0000313|EMBL:KPM03570.1};
GN   ORFNames=QR98_0020030 {ECO:0000313|EMBL:KPM03570.1};
OS   Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC   Sarcoptidae; Sarcoptinae; Sarcoptes.
OX   NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM03570.1, ECO:0000313|Proteomes:UP000616769};
RN   [1] {ECO:0000313|EMBL:KPM03570.1, ECO:0000313|Proteomes:UP000616769}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM03570.1};
RX   PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA   Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT   "Draft genome of the scabies mite.";
RL   Parasit. Vectors 8:585-585(2015).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPM03570.1}.
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DR   EMBL; JXLN01005493; KPM03570.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A131ZZM4; -.
DR   VEuPathDB; VectorBase:SSCA002787; -.
DR   OMA; NEIGICK; -.
DR   OrthoDB; 3614769at2759; -.
DR   Proteomes; UP000616769; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR45881:SF1; FORK HEAD PROTEIN HOMOLOG 2; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DNA_BIND        16..64
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
SQ   SEQUENCE   498 AA;  56006 MW;  A05F50165F9B9983 CRC64;
     MIVIEVVVSF ENTEYNSIRH NLSLNKCFIK IARNKDEPGK GGFWKLDPVY ADGLIDGIFK
     KRRANINHSK SMTATTAKVT HKQNSSLKGP IKKRCRKKYP ISLNDCENFL VDIVEPNNNH
     IEQETPPNSA ESYRYTKLEC IDELNNAIES IDGNLSYSCT FHQTNESDPM ECGTDPLIQG
     FVNEICIDQI NNECIEPEGH DLCWNTILTD VDLGELVDPI SYTDPVASII HPIENESNRN
     ALHQSNNNFM EKRNATKLVS IDLESIIVDG QDPTQSTSAL LEDQRLFYHT ENQQVQINDL
     SFSNISQMSQ VISATPNVVT CINESNLVDH WNQWNAYSSI DDTTQECSAQ SAEMILSHML
     ESNHNDMGLN EIGICKTHRN RDPNRTMTFV KTLSCSRSSS SSTPSVSTDK PETIASTTSV
     LLNPLISTSD YQTNSLSQSQ QQQQQQQHQQ QTPVTESPTN FETNNAIRSW ECKSSLDGTG
     IELENFNARP NANPDQQF
//