ID A0A132A158_SARSC Unreviewed; 787 AA.
AC A0A132A158;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
DE Flags: Fragment;
GN ORFNames=QR98_0032420 {ECO:0000313|EMBL:KPM04788.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM04788.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM04788.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM04788.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM04788.1}.
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DR EMBL; JXLN01009961; KPM04788.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A132A158; -.
DR VEuPathDB; VectorBase:SSCA001714; -.
DR OMA; CDCEAQK; -.
DR OrthoDB; 5475862at2759; -.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 4.10.1240.30; -; 1.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF60; INTEGRIN BETA-PS; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF07965; Integrin_B_tail; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 2.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 31..454
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 636..717
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 741..787
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT NON_TER 787
FT /evidence="ECO:0000313|EMBL:KPM04788.1"
SQ SEQUENCE 787 AA; 88264 MW; 714EDADBBDFBC50E CRC64;
KYKTTYFEYK DTNSPFPEQL REASQCITKT NCRDCIRTKL CSWCNVPGNY SHNRCDITSN
LQEHGCSSLY LYAPQPQFNL EEDEELSNKT DENTDPIQMK PQRISLKVLP NIPQTFQVTF
KQALDYPVDL YYLMDLSKSM EDDKAKLAEL GHVLAQTMQN LTNNFRLGFG SFVDKTVMPY
VSIVPEKLKA PCYGCAAPYG FKNHMSLDTD SSYFVQRVND TQISGNLDAP EGGFDAIMQA
IVCQNDIGWR EKSRKLLVFS TDAGFHYAGD GKLGGIVRPN DGECHLDRDG VYTESITQDY
PSISQINRKV REHHVNIIFA VTKDQFHIYN QLVGNNNHSM SLIEGSSAGM LAGDSSNVVQ
LIVDEYQKIT SAVELKDNAT NNIRMTYASE CLSQKKEQTS VCKGLRVGDH VVFDITLMVE
SCPPNENDWQ QTIKVYPVGL NDALYIDLEM ICKCDCEKDA QEKSPECGGR GSYQCGICNC
DDNYYGRRCE CDAKNSDPAK EEASCFRGND TKVCSGRGTC RCGECECFKR ESPDEEVTGK
YCECDNFSCD RFEGLVCAGP DHGTCECGAC ICKDGWSGPD CSCKVGNEGC IKDPTTGKIC
SGHGECICGQ CVCFNNETEQ YTGQFCDECP TCKKHCDLYK DCVQCLVFNT GPLAEDQCRN
CTINPITTNE LDSKEGELCV VWDENDCVFN FKYQYDEHEE LVYIYAQETK DCPEPVNVLA
IVIGVIVGIV LIGLAFLLIW KLLTTIKDRR EVAKFNEERL NAKWETGVNP IFKKATSTFK
NPTYSGK
//
