ID A0A132A776_SARSC Unreviewed; 681 AA.
AC A0A132A776;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=mRNA (guanine-N(7))-methyltransferase {ECO:0000256|ARBA:ARBA00011926};
DE EC=2.1.1.56 {ECO:0000256|ARBA:ARBA00011926};
GN ORFNames=QR98_0052910 {ECO:0000313|EMBL:KPM06812.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM06812.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM06812.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM06812.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA +
CC S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-
CC triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:67008, Rhea:RHEA-COMP:17166, Rhea:RHEA-
CC COMP:17167, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:156461,
CC ChEBI:CHEBI:167617; EC=2.1.1.56;
CC Evidence={ECO:0000256|ARBA:ARBA00024288};
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000256|ARBA:ARBA00007337}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the dsDNA virus mRNA
CC guanylyltransferase family. {ECO:0000256|ARBA:ARBA00008556}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM06812.1}.
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DR EMBL; JXLN01011121; KPM06812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A132A776; -.
DR VEuPathDB; VectorBase:SSCA003805; -.
DR OrthoDB; 167537at2759; -.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0004482; F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004971; mRNA_G-N7_MeTrfase_dom.
DR InterPro; IPR039753; RG7MT1.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR001921; Ribosomal_eL8.
DR InterPro; IPR004038; Ribosomal_eL8/eL30/eS12/Gad45.
DR InterPro; IPR018492; Ribosomal_eL8/Nhp2.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12189:SF2; MRNA CAP GUANINE-N7 METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12189; MRNA GUANINE-7- METHYLTRANSFERASE; 1.
DR Pfam; PF03291; mRNA_G-N7_MeTrfase; 2.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00882; RIBOSOMALL7A.
DR SUPFAM; SSF55315; L30e-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51562; RNA_CAP0_MT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KPM06812.1};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 45..429
FT /note="MRNA cap 0 methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51562"
SQ SEQUENCE 681 AA; 79021 MW; D1CCBD7AA6234D71 CRC64;
MNSKRPKIDE FYRRSDCGSH RDRKYSSFES SKSSSDVKDS LLYDHDDDER TDKSSNNSSS
SISTIVANHY NSINNNDIQE RKKSRIYHMR NFNNWVKSII IRDTIKLLRS KQTNQDNSEF
IVHDLACGKG GDLTKFDKSR ITHFIGSGIL LKFFPLDRLK FYSSLSVTDI AEISIEHCKE
RYRLFEKNFS AEFHTIDCTR ELIKDRLRDN NIKFDMTSCQ FSFHYCFESY EQVCNMVRNA
SENLKVGGIF CGTIPDSMEI MKRLKDCGTN EYGNDVYSIR FDQTYDEIMS DGAPLFGLKY
YFHLDEVVDC PEFLVYFPVM EEICKSFGLK LIFKKRFDEF YEENHCGDEN SNLLNFMEAL
EKYPPRDRER SMGRPSDYKH IRQYLSENVL SPSNLKSLGT LSKSEWECIT LYLKIVKKKT
APLPAVIAAK MQKKKKVVDP LIQKRPKNFS IGGNIQPKRD LTRFFKWPRY VQIQRRRAIL
YQRLKVPPSI NQFRSNLLDR QTATQLFRLL DKYRPETKRA KLERLRKKAK SKAEGKEVTP
TKRPPVVKIG ANAVTTAVEK KTAQLVCISA DCDPIEVVIH LPNLCRKMGI PYCIVRGGRS
RLGQVARLKS CAALAITQIN PEDKVALTNL VEVLRTNFND RFDEIRKHWG GGVMSAKSRA
KVAKLEKAKA KELENWRVCN R
//
