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Database: UniProt
Entry: A0A132ABB2_SARSC
LinkDB: A0A132ABB2_SARSC
Original site: A0A132ABB2_SARSC 
ID   A0A132ABB2_SARSC        Unreviewed;       704 AA.
AC   A0A132ABB2;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   03-JUL-2019, entry version 24.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   ORFNames=QR98_0067640 {ECO:0000313|EMBL:KPM08248.1};
OS   Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Acari; Acariformes; Sarcoptiformes; Astigmata; Psoroptidia;
OC   Sarcoptoidea; Sarcoptidae; Sarcoptinae; Sarcoptes.
OX   NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM08248.1};
RN   [1] {ECO:0000313|EMBL:KPM08248.1, ECO:0000313|VectorBase:SSCA008207-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM08248.1};
RX   PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA   Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT   "Draft genome of the scabies mite.";
RL   Parasit. Vectors 8:585-585(2015).
RN   [2] {ECO:0000313|VectorBase:SSCA008207-PA}
RP   IDENTIFICATION.
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; JXLN01012244; KPM08248.1; -; Genomic_DNA.
DR   EnsemblMetazoa; SSCA008207-RA; SSCA008207-PA; SSCA008207.
DR   VectorBase; SSCA008207-RA; SSCA008207-PA; SSCA008207.
DR   OMA; WFDGVVE; -.
DR   OrthoDB; 327469at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      579    679       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      133    153       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   704 AA;  81074 MW;  618951AB5E4D95E9 CRC64;
     MWTLQHNIPE EIQHQISLVY GTDVFPLEVR TVLAEWIEKQ PWSKVVSENS TECETLAANL
     HQEFILKVNS LAHSIENNQF KYRLSQVAFN AQHRNPLEIA NIIYFSLQKE SKILSYAQNC
     LLETKSLRHR DSFQEINRDI QRIRKDMAEL DEIIRKTFQD QEQLMLQCQE RQKCQSMLQN
     TSISDRNKLL KQLQESSSFQ AASEALLKQR SESLERLKES HNLLTLLMNR VIDIELASWH
     RGQQLLGNGV MYTGYTLDDI QDWCETITDF IRQNRIQIKR LQFFCTNYTP NQYINESLCN
     LMSSNTSLLN KLVRSTFVIE KQPPQVMKTN TRFTAIVRLL VGCKINLHLA PPSVTVHIIS
     EHQAALITNG SDNNASVIQN ESAAGEIMNN VGVMEYHAAT THLSVHFRNM QLKKIKRTEK
     KGTESVMDEK FALLFNTRFT INQEFADTQM PFNVQTFSLP VVVIVHGNQE PHAHATITWD
     NAFAEQRRIS FLVPDKVPFY RVGEVLSQKF IANVGKGLSQ DNLRFLAAKA LRTNSVPDLN
     VLITWSQFSK EPLSDRNFTF WEWFYSVLKI TKEHLRALWN DGLIHGFVSR TETNNMLSQC
     PLGTFLLRFS DSEQGGLTVA WKGKSQEDNI ENCFMLQPFN SKDLGIRSLA DRLNDLKYLT
     HLYPDTPKDA VFSKYYTPFG ETSKTNTGYV KPLLVTCVPG QVEI
//
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