GenomeNet

Database: UniProt
Entry: A0A132ACR3_SARSC
LinkDB: A0A132ACR3_SARSC
Original site: A0A132ACR3_SARSC 
ID   A0A132ACR3_SARSC        Unreviewed;      3566 AA.
AC   A0A132ACR3;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   08-MAY-2019, entry version 23.
DE   SubName: Full=Low-density lipoprotein receptor-related protein 2-like protein 4 {ECO:0000313|EMBL:KPM08784.1};
DE   SubName: Full=Low-density lipoprotein receptor-related protein 2-like protein 4 (Fragment) (Fragment) {ECO:0000313|VectorBase:SSCA001271-PA};
DE   Flags: Fragment;
GN   ORFNames=QR98_0073090 {ECO:0000313|EMBL:KPM08784.1};
OS   Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Acari; Acariformes; Sarcoptiformes; Astigmata; Psoroptidia;
OC   Sarcoptoidea; Sarcoptidae; Sarcoptinae; Sarcoptes.
OX   NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM08784.1};
RN   [1] {ECO:0000313|EMBL:KPM08784.1, ECO:0000313|VectorBase:SSCA001271-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM08784.1};
RX   PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA   Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT   "Draft genome of the scabies mite.";
RL   Parasit. Vectors 8:585-585(2015).
RN   [2] {ECO:0000313|VectorBase:SSCA001271-PA}
RP   IDENTIFICATION.
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; JXLN01012695; KPM08784.1; -; Genomic_DNA.
DR   EnsemblMetazoa; SSCA001271-RA; SSCA001271-PA; SSCA001271.
DR   VectorBase; SSCA001271-RA; SSCA001271-PA; SSCA001271.
DR   OMA; PWGIAVY; -.
DR   OrthoDB; 1606at2759; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00112; LDLa; 26.
DR   Gene3D; 2.120.10.30; -; 7.
DR   Gene3D; 4.10.400.10; -; 29.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR032485; DUF5050.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF16472; DUF5050; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF00057; Ldl_recept_a; 28.
DR   Pfam; PF00058; Ldl_recept_b; 8.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 17.
DR   SMART; SM00179; EGF_CA; 5.
DR   SMART; SM00192; LDLa; 29.
DR   SMART; SM00135; LY; 32.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   SUPFAM; SSF57424; SSF57424; 28.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 4.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS01209; LDLRA_1; 15.
DR   PROSITE; PS50068; LDLRA_2; 29.
DR   PROSITE; PS51120; LDLRB; 32.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00602928};
KW   Lipoprotein {ECO:0000313|EMBL:KPM08784.1};
KW   Receptor {ECO:0000313|EMBL:KPM08784.1};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563}.
FT   REPEAT       16     62       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT       63    105       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      106    146       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      147    189       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      190    235       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      338    380       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      381    423       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      424    467       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT      468    510       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   DOMAIN      981   1019       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REPEAT     1066   1108       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1109   1151       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1154   1197       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1198   1242       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1243   1283       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   DOMAIN     1288   1324       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REPEAT     1379   1427       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1428   1477       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1478   1524       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1525   1569       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1700   1747       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1748   1792       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1793   1836       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     1837   1878       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2020   2064       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2065   2105       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2106   2152       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2153   2194       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2195   2236       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   DOMAIN     2241   2282       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     2713   2754       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REPEAT     2843   2885       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2886   2928       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2929   2974       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     2975   3018       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   REPEAT     3019   3059       LDL-receptor class B.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00461}.
FT   DISULFID    625    643       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    657    669       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    664    682       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    676    691       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    696    708       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    703    721       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    756    771       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    796    811       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    861    873       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    868    886       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    985    995       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   2288   2300       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2295   2313       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2329   2341       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2336   2354       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2348   2363       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2368   2380       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2375   2393       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2498   2510       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2505   2523       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2591   2603       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2598   2616       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2631   2643       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   2638   2656       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3130   3145       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3170   3185       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3239   3257       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3324   3342       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3360   3372       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3367   3385       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3379   3394       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3399   3411       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3406   3424       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3418   3433       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3443   3455       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3450   3468       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3492   3510       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3529   3541       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3536   3554       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID   3548   3563       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   NON_TER    3566   3566       {ECO:0000313|EMBL:KPM08784.1}.
SQ   SEQUENCE   3566 AA;  404121 MW;  3F64C8BF9B7F0A43 CRC64;
     MNATAASGLD FHYAKNILFW SDVETRKIYS INLDPNRPTK FTKEISVFYT WTPMSIAIDW
     IANKIYICDT HNQKIDIMEF DGSHHSIVIS QNLTAPLDIA LDPTRGLMFF TDNDNINRAL
     MDGTQRKTIV SNFIYKATGI TLDYVTQRIF WCDSQLDQIV TVNYEGQERH TIIRGSTKVP
     SPVRMTVFEN YAYWTDSTRQ GVLRLNLYKT SDIEILYRER TIVKEPRSIK SVHALRQPIV
     FNPCFTDNGK CEHMCVLTRN GFDNSFALGY RCACDIGYEL ADNLRSCRKI EEFLMYSQQK
     FVRGIILEPK ISGFTDAIVP VVSRSARFVG LDFDARTNHI FYSDVILDVI YKIKVDGTGR
     ENVLASQNEG VEGLAHDWIS HNLYYIDSRK GTLNVISVKN STYRRVLLKN LKRPRAIVVH
     PNRGYIFYSE WERPANISRA YLDGTNVMIF RGVLLGWPNG LSIDYENDRL YWCDALLDHI
     QHANLDGTDV KTINSPRIKH PFSLVIHREW LYVTDWRLDA ILRINKLTGA DEKIINTVEE
     GSRLYGIRVF SVDAQNIDTL HPCLYTNGDC QKFCFAIPEN DTNQLSVRCG CPYGEKLAED
     GHNCILDPVK EPPLQSCPNS WDFTCENQRC IPKSWVCDGD NDCLDGSDEQ QNCTQPCSSR
     DFKCASGRCV PMGFKCDKDN DCGDFSDEIG CANITCSANE FTCENGRCIS MSWKCDSEND
     CGDGSDEGDS CKEKTCSFFQ FTCPGSGHCI PESWVCDGEN DCIDQADEKN CPPIVCSRNQ
     FKCADRKQCL HESYHCDGMK DCQDGSDEKD CPQLSPNQCD PEKQFQCKTS RICIPKLWYC
     DGNPDCEDNS DEPQSCGQIV CPTNHFKCDN SRCVFKSWIC DGRDDCGDNS DEDKRHACGA
     VRYECPSDQW SCPNVTNRCI PVKNICDGRA DCPNGSDEGP GCGLVSCKSQ NCLHQCKETP
     WGPLCLCPPG EKLNGTTTCI DIDECEQIGT CSHNCFNEKG GFKCFCEPGY QLENHTYCKA
     LNRTEAYMVI SNRKSILIAN ITNVSLERIP VRVENVVATA SEMSTGVIYW YDMHTKKIYR
     IQNRTSEPEV VINSGLDLVE GLAIDWIAKN LYWVDSRLKT IEVSTSDGRN HIVLLSQNIS
     QPRGICLDPR EGARILFWSD WGENPRIERM GMDGSERKVI VSTKIYWPNG LTIDIPTKRI
     YFADSKLDYI DFCNYDGSDR QQVLAHNHYL LHPHSLTIFE DTLYWTDRQL NRVLSCHKFR
     GSNQTVVSHL VSQPLGIHIN HPVVQPEEPN PCVKAPCSHL CLLSPSSPGY TCKCPPGYGQ
     DRTLVGGRCI PIETPYLMAM KTSQIFDLSL TPNEKSIGYF TPIIGIENGY DFDYDKQEGF
     IYYVQLREED KENGTLYKVS LTGGNQTKFL PDGIVGAPYC LAFDWLGRNL YVGNKKSSNI
     LVIKTDGDKN YRRIILSNDG TEKGVAKPKS IVLDPMQGKL YWLDEGGVGV PQKLAKSSMD
     GSDPQILIKD SLHQVEALTF DFNNRRIYFS QSFVGVIESI DENGKDRRTI ITSSSGIAKP
     QGLSIYNNRL YYLDSIYEKI VRVNLPDGSN AISIEDNSPN LANLKIYSKR SGLENHPCRI
     GNGGCQQLCI PDSNNQRKCL CSTGFRTDGQ TNCQPYKSFA VVSLLNKMQG FSLEDHAEAI
     QPIAGPGHNI LHIDVHVVKN HIYWVEYNPG ERNGIYRIKP DGSEKSHIIS DGIGSNGIRG
     IAIDWIAGNL YFTNVFPHET YIEVSHLDGK NRMILIKTTT DAPREIAVNP IKRYLYWIDY
     GQFPKIEKAL LDGTNRTPIV VTGISNPRDL TIDIVTHDVY WVDAREDAIQ KVSFSGGRRQ
     YVWRNLPTPY GASILGSQIY WVDRNLRTIF RGSKLFEDAQ TQIPEPFKSN LDTLRDIVIF
     DAQNQPPGDS ICSLRGDRIC DQLCFAMPSG MDLQFKCACS SGMLDKVDGK KCQPLEEYLI
     FTTRKEIRTI NLDESISSPP VMPRTNLTNV VGLDFDFANK KVFFTQIRPD GGISSYQIKP
     TDDINHPILS KGINPEGIAF DWTNRKIYWT DSANRSIYSM NEDGSQIVMI ARVERPRAIV
     LDPCEGYIYF TDWGKFGNNG KIYRTTMAGN FKRTIINDNL TQPSGLAIDY EERKLYWTDA
     LREKIERSDL NGTNREILIS ATIYPFALTV FGNYIYWTDL QLRGVYRANK YTGSDMIELV
     KRLEESPRDI HVFSSQRQLC DKNPCQINNG GCAHSCHQAP NQTFECRCST GFKLANENRM
     CVPENISCDE TKFSCTNGKC IPRLWACDGD DDCGDSSDED AVFCSAHTCG PNEFRCGNGR
     CVFKTWRCDH ENDCGDGSDE DDCVYPPCAE GEFTCVNHKC IPIAQLCNGV NDCKDANTTD
     ENHINCPTNK TCPVDHLKCS NTNICVEPYW LCDGDNDCGD NSDENVMICS QRTCPPNSFR
     CPNNHRCIPA TWYCDGDDDC GDKSDEPEDY CKSDQRTCFG DLFTCNNGNC IPRIYICDGD
     NDCLDNSDED ERHQCETRTC DPEREFTCTA NKNWGRSQCI PKRWICDGDP DCVDGADEDI
     TLHSCPPPEP CDVDQFRCNN NRCISKEWVC DHDNDCGDGS DEYRNCTFRD CKEDEFSCRN
     TKCIKKTYLC DGEDDCGDGS DENLPKCHEN ANKSRCASYE FACKTNTQCI QSSLVCNKKL
     DCEDGSDESP HCNVNECLKT EINQCEHQCI DEMIGFHCDC NPGYRLAIDG KACEDINECV
     DVKSVCSQYC SNTPGSFYCK CNDLYYERML DGHTCKRIDN VEPWLIFSNR YYLRNVSTDG
     HLYNLIKMEL KNVVALDFDY RTERLYYADV GNKSINRIFI NGTGEETIIR HEAHGLEGIA
     VDWVGRKLYW MDRTSKHIDV SELDGTHRKT ILSRGMSDPR AIVAHPKIGF LFFTDWGHHA
     CIGKIGLDGR NFSRIITYEK KLVWPNALTI DYFSDKLFWA DAHLDYIEYS DFDGKNRHTV
     LSGNSVPHVF AMSVFDDWLY WTDWNTKGLA RAHKFTGANY QVLRNTSHRP YDIHVYHPLR
     QIAHDNPCGE NNGGCSHLCL ISPGGQSFTC ACPNNFILLR DNKTCIANCT KGQHRCGGND
     DRCIPIFWNC DGDKDCRDGS DELNCPPFQC KPGMFQCRNN STCISRIRIC DGVHDCTDGS
     DESFCDNDCG EHSFKCQLTG RCVPSSWQCD GDNDCSDGSD ENPLICHHRE CDKDTQFRCD
     NGKCIPKLWH CDFDDDCGDN SDEPAHLCRN RNCSTGWQKC PSRLNYRCIP SWLFCDGKDD
     CRDNSDETHP ESCPVCHKTG DFKCKNDRCI PLRWRCDFED DCGDNSDENP SMCSELYREC
     SESEFQCNNR KCVPSRWRCD HDEDCDDGSD EINCLEHQCK PEQFKCKSGH CISNKLVCDG
     NKDCKDVSDE LNCPPRFPNG RHCAESSFQC NNTVCLRNEF LCDGDDDCGD GSDESESMCQ
     NFECDPSKKF QCHNKKCIPL WLICNGFDEC GDGSDENNHT LCRKWPTLCS SNQYKCANDR
     CIEMSKVCDH FDDCGDLSDE KGCHQG
//
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