ID A0A132ACX7_SARSC Unreviewed; 824 AA.
AC A0A132ACX7;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KPM08773.1};
GN ORFNames=QR98_0072970 {ECO:0000313|EMBL:KPM08773.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM08773.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM08773.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM08773.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM08773.1}.
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DR EMBL; JXLN01012684; KPM08773.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A132ACX7; -.
DR VEuPathDB; VectorBase:SSCA004504; -.
DR OrthoDB; 4064096at2759; -.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.15.10.30; Haemolymph juvenile hormone binding protein; 1.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR010562; Haemolymph_juvenile_hormone-bd.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR038606; To_sf.
DR PANTHER; PTHR45624; MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR45624:SF12; MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN S-RELATED; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF06585; JHBP; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SMART; SM00700; JHBP; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}.
FT REPEAT 66..155
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 168..251
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT DOMAIN 547..590
FT /note="Heme NO-binding"
FT /evidence="ECO:0000259|Pfam:PF07700"
FT DOMAIN 638..786
FT /note="Haem NO binding associated"
FT /evidence="ECO:0000259|Pfam:PF07701"
SQ SEQUENCE 824 AA; 94430 MW; 435E6F31B8C1830E CRC64;
MQTFPNLYKN PWICFKQTFS KEGIRRGLYA GTSPALLANV AENSVLFCAY GFCQNLIKNF
RNKNSLNTLE NATAGFMAAF FSSFTLCPTE LIKCKLQALR ETGHHSSNIT SYQLTRSILK
QEGIAGLFRG LTSTMFREMP GYFFFFGGCE YTKSMFRSSK NQDLHQELGL VQSILAGGIG
GVCLWISIFP FDVVKSRIQI ESSTKSMRKV FLEIFRNEGI RGLYNGLTPT LLRTFPSTGS
VFSYSASDNQ PFRFIQDYAL ETVDLRNLEE NFTEYFHEII ISKLANEMKS GIPAMSIPPM
DPLRLNEIKV EPNIANEKFT IHLNNIEVKG LSDLEVQDLR PRLNSLKVRL ALLFPKLIST
CLFNVNGSIY KLIDVRGEGQ ARLEYNNVLV RAQLDLAYEN RTFKIISSDS PMIDFNTAKI
VLTDENKEGL ETESTKQVTA SELGPLLFWV LADHIVQDID EYLLKYFNNN LLLFKVPETF
KPAITWLMNR SGGNNQGDDQ SPNDDGNYVF VNNNNDPNRP PYPQTMMLND DFGIIHNCIE
DFVIRFFRIT HSEEGTMRLF YHSDRKGLDS FVKGLITAAS QLIFRTEVIV NRLPMGKDGA
IQYEIINKSI DLNSEAFEKI KTPIVSSYLS TSLSHLLFSV ETLCESLPFH FVFKRNFRIV
QIGNKLKRFI NQDLLQFNGK IVFSDLFIIS RPIIDLDFEM ILNFSNHLFN LTGRDKYVRQ
IDRQKRRNSY RLNSTTSSQT LEPIKLKLRG QMISLPVYDS ILFVGYPEID HLEQMLDLDL
TIDDLTENAA RFYVTRALSE DDHEIIKKIE IAVNHLKIIK KKLR
//
