ID A0A132AJ54_SARSC Unreviewed; 883 AA.
AC A0A132AJ54;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN ORFNames=QR98_0095120 {ECO:0000313|EMBL:KPM10947.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM10947.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM10947.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM10947.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM10947.1}.
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DR EMBL; JXLN01016099; KPM10947.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A132AJ54; -.
DR VEuPathDB; VectorBase:SSCA010284; -.
DR OMA; NFAPICG; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd17336; MFS_SLCO_OATP; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF159; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 74D; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 138..159
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 166..187
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 250..276
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 288..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 520..538
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 558..576
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 588..610
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 719..743
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 755..777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 806..827
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
SQ SEQUENCE 883 AA; 98295 MW; FF2D21D626E57F49 CRC64;
MSPFIDRKQP SNGHRNDDQK VDIDNNLGCI DRIPRISTSN ANNNNQLISD LKIKSDRFDS
STPTKFSIVE DMKELDRDIS CGIFRWHPQF LQCLANKKCF LALFCLISVL QGIYYTYFVS
VLTTIEKLYQ VQSRTTGIIM SSTEIGQISG ALLLTYYGGQ GHRPRWIAAG MLVFAFAALL
CSTPHYLFGT GTRASQSISN VFDAQQSFAS TPPSSLCVMN SSINNHNDDN LFCSEQKSDG
FLQTNRSTDY VLGIFFLSLL MIGLGTTTVN TLGIPYIDDN VAPKESPLYF GITIGVRIFG
PVCGFLLGSI CTSIPVQFPF GYSDLDSNDP NWIGAWWLGL FLVGISLAIS SIPMMLFPRK
LPQPDPSSYC HKQQQKEQEN INKYYKNSIA NHHHHHHSDP NDYNQKLITK ELDNTELVKF
ADIDSNTSSS SSSSTSTIPM SSNNHDQYVI DTEADDHLLD ETTKTIVQKT DFDDNFTGKH
PMIDCSLSRS STNAFDSNDS QPTFRGFSQA LKRLLTNDIL LCRTASSVLH ILPISGLYTF
LPKYLESQFK LTATDANIIA GLAGILVMGI GIFASGTFMQ KFNSSASFVA KWIAFAALSY
VIGMVLLMFI GCSNTEFSGL TNDLESDYFV TMSNERLECS ANCNCPSGRF EPICLDGRTT
YLSPCLAGCS TIYLNKTMKF YSNCSCLANH FPPTRSEFDD MSTLIKPGIC PLQCNTLPLY
IIIFSLTVLI HSTSEVGSML LTLRCVEPRD KAMALGFLSF ATGLFGNVPC PIIYGSIVDS
TCLFWEESCG KRGACRLYDS DRFRQLFHGV TAFIMLLAFF IDLIVCYKAS SIQFHDEHNE
NGDEKKKKSS SSNRIDGERL MIENGESDLI KKNNSLSIDF ERK
//
