ID A0A132MM59_9ACTN Unreviewed; 680 AA.
AC A0A132MM59;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=LI90_577 {ECO:0000313|EMBL:KWW98947.1};
OS Carbonactinospora thermoautotrophica.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Carbonactinosporaceae; Carbonactinospora.
OX NCBI_TaxID=1469144 {ECO:0000313|EMBL:KWW98947.1, ECO:0000313|Proteomes:UP000070188};
RN [1] {ECO:0000313|Proteomes:UP000070188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H1 {ECO:0000313|Proteomes:UP000070188};
RA MacKellar D.C., Lieber L., Norman J., Bolger A., Tobin C., Murray J.W.,
RA Chang R., Ford T., Nguyen P.Q., Woodward J., Permingeat H., Joshi N.S.,
RA Silver P.A., Usadel B., Rutherford A.W., Friesen M., Prell J.;
RT "Physiological reanalysis, assessment of diazotrophy, and genome sequences
RT of multiple isolates of Streptomyces thermoautotrophicus.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWW98947.1}.
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DR EMBL; LAXD01000001; KWW98947.1; -; Genomic_DNA.
DR RefSeq; WP_066883915.1; NZ_LAXD01000001.1.
DR AlphaFoldDB; A0A132MM59; -.
DR STRING; 1469144.LI90_577; -.
DR PATRIC; fig|1469144.10.peg.674; -.
DR OrthoDB; 8865355at2; -.
DR Proteomes; UP000070188; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Glycosyltransferase {ECO:0000313|EMBL:KWW98947.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000070188};
KW Transferase {ECO:0000313|EMBL:KWW98947.1}.
FT DOMAIN 77..263
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 362..630
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 680 AA; 73219 MW; E7AC31DB518791BD CRC64;
MVPRIRPVRQ RGNTRAGLSS FVAASALAGV LVAGLLLPFA SAAGLAAKQG AEYYNSLPAG
LPEQELSQRS VLLAADGSPL AAFYEQNRIV VPLAKIAPVM QRAMLAVEDA RFYQHGPVDP
KAVIRALVQN LKAGDVEQGA SSLTQQYVKN MLIQTAHGDQ KKIKEATAPT LKRKIQELKY
AAEVEKRLTK DQILEAYLNI AYFGDGVYGV EAAARHYFRK SAALLTLPEA ALIAGLVRQP
GMYDPTHAPQ AARSRRNTVL DRMAAVGFIT SAEAARAKQA PLGLDVVPMG NGCERSKAPF
FCEYALSVIL SDPVFGKTAR ERRDLLLRGG LRIQTTLDPR AQEAAQRAID ARIEPDNEVA
MALAMVQPGT GAVKAIATNR RFGNGRGQTK VNLAVDKRDG GSSGFQAGST FKPFVLATAI
KQGVPVTKTF NAPPAITLSG FRFCDSGRRY PPWAVSNYEG LGYGAIDMRV ATWRSVNTYF
AQLEQLTTQC EAVKTAHLLG VRRADGRPLE TVPSFVLGSQ EVSPLAMAEA YATFAARGVH
CESRPISAVI DRNGSKLPIP PPKCRWVLDP RVADTVNSVL AGVIDGPDRQ RTGGRLTLGR
PAAGKTGTTD STVAVWFVGY TPDLSTAVWT GYPDRSRPMR SLVLRGKHYP RVSGARVPGP
VWQEAMKGAL ADTPPRPFGR
//
