ID A0A132N5D4_9ACTN Unreviewed; 187 AA.
AC A0A132N5D4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=HIT family hydrolase {ECO:0000313|EMBL:KWX05355.1};
DE SubName: Full=Putative histidine triad (HIT) family protein {ECO:0000313|EMBL:KWX00646.1};
GN ORFNames=LI90_1669 {ECO:0000313|EMBL:KWX00646.1}, TH66_03810
GN {ECO:0000313|EMBL:KWX05355.1};
OS Carbonactinospora thermoautotrophica.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Carbonactinosporaceae; Carbonactinospora.
OX NCBI_TaxID=1469144 {ECO:0000313|EMBL:KWX05355.1, ECO:0000313|Proteomes:UP000070659};
RN [1] {ECO:0000313|EMBL:KWX05355.1, ECO:0000313|Proteomes:UP000070659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UBT1 {ECO:0000313|EMBL:KWX05355.1,
RC ECO:0000313|Proteomes:UP000070659};
RA MacKellar D.C., Lieber L., Norman J., Bolger A., Tobin C., Murray J.W.,
RA Prell J.;
RT "Physiological reanalysis, assessment of diazotrophy, and genome sequences
RT of multiple isolates of Streptomyces thermoautotrophicus.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KWX00646.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H1 {ECO:0000313|EMBL:KWX00646.1};
RA MacKellar D.C., Lieber L., Norman J., Bolger A., Tobin C., Murray J.W.,
RA Woodward J., Friesen M., Prell J.;
RT "Physiological reanalysis, assessment of diazotrophy, and genome sequences
RT of multiple isolates of Streptomyces thermoautotrophicus.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000070188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H1 {ECO:0000313|Proteomes:UP000070188};
RA MacKellar D.C., Lieber L., Norman J., Bolger A., Tobin C., Murray J.W.,
RA Chang R., Ford T., Nguyen P.Q., Woodward J., Permingeat H., Joshi N.S.,
RA Silver P.A., Usadel B., Rutherford A.W., Friesen M., Prell J.;
RT "Physiological reanalysis, assessment of diazotrophy, and genome sequences
RT of multiple isolates of Streptomyces thermoautotrophicus.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX05355.1}.
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DR EMBL; LAXD01000001; KWX00646.1; -; Genomic_DNA.
DR EMBL; JYIJ01000012; KWX05355.1; -; Genomic_DNA.
DR RefSeq; WP_066886260.1; NZ_PQID01000013.1.
DR AlphaFoldDB; A0A132N5D4; -.
DR STRING; 1469144.LI90_1669; -.
DR PATRIC; fig|1469144.10.peg.1817; -.
DR OrthoDB; 9784774at2; -.
DR Proteomes; UP000070188; Unassembled WGS sequence.
DR Proteomes; UP000070659; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR CDD; cd01275; FHIT; 1.
DR Gene3D; 3.30.428.10; HIT-like; 1.
DR InterPro; IPR039383; FHIT.
DR InterPro; IPR011146; HIT-like.
DR InterPro; IPR036265; HIT-like_sf.
DR PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR Pfam; PF01230; HIT; 1.
DR SUPFAM; SSF54197; HIT-like; 1.
DR PROSITE; PS51084; HIT_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KWX05355.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000070188}.
FT DOMAIN 50..159
FT /note="HIT"
FT /evidence="ECO:0000259|PROSITE:PS51084"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 144..148
FT /note="Histidine triad motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT ACT_SITE 146
FT /note="Tele-AMP-histidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT BINDING 76
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT BINDING 148
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ SEQUENCE 187 AA; 20695 MW; 9C9E0676E9C11370 CRC64;
MLQSMDRPEP EPQNGVGIPD AFQRLWTPHR MAYIKGENKP RGPGEDDGCP FCEITRLDDA
DGLIVARGKL VYAVLNLYPY NPGHLMVCPY RHVADYTDLD PDETAELAEY TKRAMRALRA
AAGAHGFNIG MNQGPVAGAG IAAHLHQHIV PRWGGDTNFM PVVGHTKVLP QLLSQTREML
VEAWPED
//