ID   A0A132NDN7_HYDSH        Unreviewed;       353 AA.
AC   A0A132NDN7;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   03-MAY-2023, entry version 25.
DE   SubName: Full=Peptidase M28 {ECO:0000313|EMBL:OAR05046.1};
GN   ORFNames=SA87_05785 {ECO:0000313|EMBL:OAR05046.1};
OS   Hydrogenibacillus schlegelii (Bacillus schlegelii).
OC   Bacteria; Bacillota; Bacilli; Bacillales;
OC   Bacillales Family X. Incertae Sedis; Hydrogenibacillus.
OX   NCBI_TaxID=1484 {ECO:0000313|EMBL:OAR05046.1, ECO:0000313|Proteomes:UP000243024};
RN   [1] {ECO:0000313|EMBL:OAR05046.1, ECO:0000313|Proteomes:UP000243024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MA 48 {ECO:0000313|EMBL:OAR05046.1,
RC   ECO:0000313|Proteomes:UP000243024};
RA   Hemp J.;
RT   "Draft genome sequence of Hydrogenibacillus schlegelii DSM 2000.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001123-2};
CC       Note=Binds 2 divalent metal cations per subunit.
CC       {ECO:0000256|PIRSR:PIRSR001123-2};
CC   -!- SIMILARITY: Belongs to the peptidase M42 family.
CC       {ECO:0000256|ARBA:ARBA00006272, ECO:0000256|PIRNR:PIRNR001123}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAR05046.1}.
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DR   EMBL; JXBB01000006; OAR05046.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A132NDN7; -.
DR   STRING; 1484.SA87_05785; -.
DR   Proteomes; UP000243024; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd05656; M42_Frv; 1.
DR   Gene3D; 2.40.30.40; Peptidase M42, domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR008007; Peptidase_M42.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   PANTHER; PTHR32481; AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR32481:SF0; AMINOPEPTIDASE YPDE-RELATED; 1.
DR   Pfam; PF05343; Peptidase_M42; 1.
DR   PIRSF; PIRSF001123; PepA_GA; 1.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR001123-2}; Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000243024}.
FT   ACT_SITE        211
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001123-1"
FT   BINDING         65
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001123-2"
FT   BINDING         179
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001123-2"
FT   BINDING         179
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001123-2"
FT   BINDING         212
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001123-2"
FT   BINDING         234
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001123-2"
FT   BINDING         318
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001123-2"
SQ   SEQUENCE   353 AA;  37493 MW;  99C2A9E4F4188789 CRC64;
     MPYDEALFRQ LIEAPGAPGF EGEVRRVVEA ALAGAADRMI RDRLGSLFGV LDGPEGGPTV
     MVAGHLDEVA LMVTEVTDDG LLKVTALGGI YEPVLLAQRV FVLGRNGAVP GVIGAPPPHG
     LSEEARREAP QLERMFVDVG AASREDVRAF GIRPGDPVVF PGVYTPSWSG RRVLAKAWDN
     RFGVGLAVEL LRALRDRPRV NTVVAGATVQ EEVGLRGAET AARLVRPDVF FALDAGPAGD
     MPGGSGLGRL GGGVLMRVMD RTMVTHRRLL DYLLDLAEAE GIPYQFFVSR GGTDAGRVHT
     MGIGVPSAVI GIPARYIHGP VAIIDLDDYR AAKRLLIAAV SRLDRATLEA IVG
//