ID A0A132P3Y6_ENTFC Unreviewed; 194 AA.
AC A0A132P3Y6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Peptidyl-prolyl cis-trans isomerase {ECO:0000256|RuleBase:RU363019};
DE Short=PPIase {ECO:0000256|RuleBase:RU363019};
DE EC=5.2.1.8 {ECO:0000256|RuleBase:RU363019};
GN Name=ppi {ECO:0000313|EMBL:BDP58050.1};
GN ORFNames=AWT83_00380 {ECO:0000313|EMBL:KWX17040.1}, B4W81_08345
GN {ECO:0000313|EMBL:AQY31992.1}, CQR37_06335
GN {ECO:0000313|EMBL:PHL21896.1}, CUN04_11960
GN {ECO:0000313|EMBL:PQC74071.1}, EB12_01829
GN {ECO:0000313|EMBL:RBS29589.1}, EFM1CSP_17770
GN {ECO:0000313|EMBL:OSP67575.1}, EfmJHP36_25290
GN {ECO:0000313|EMBL:BDP58050.1}, FHK66_13115
GN {ECO:0000313|EMBL:QDA39349.1}, FIU59_12410
GN {ECO:0000313|EMBL:TNW90060.1}, GBM44_10920
GN {ECO:0000313|EMBL:KAB7618430.1}, GBM73_13060
GN {ECO:0000313|EMBL:KAB7578167.1}, KYX88_10050
GN {ECO:0000313|EMBL:MBX4223154.1}, M3X98_11975
GN {ECO:0000313|EMBL:MDC4248752.1};
OS Enterococcus faecium (Streptococcus faecium).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1352 {ECO:0000313|EMBL:KWX17040.1, ECO:0000313|Proteomes:UP000070452};
RN [1] {ECO:0000313|EMBL:RBS29589.1, ECO:0000313|Proteomes:UP000253144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=131EA1 {ECO:0000313|EMBL:RBS29589.1,
RC ECO:0000313|Proteomes:UP000253144};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Van Tyne D., Lebreton F., Saavedra J.T., Gilmore M.S.,
RA Manson Mcguire A., Clock S., Crupain M., Rangan U., Young S.,
RA Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., Shea T.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus faecium 131EA1.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KWX17040.1, ECO:0000313|Proteomes:UP000070452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D344RRF x C68 {ECO:0000313|EMBL:KWX17040.1,
RC ECO:0000313|Proteomes:UP000070452};
RA Garcia-Solache M.A., Lebreton F., Mclaughlin R.E., Whiteaker J.D.,
RA Gilmore M.S., Rice L.B.;
RT "Molecular Mechanisms for transfer of large genomic segments between
RT Enterococcus faecium strains.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AQY31992.1, ECO:0000313|Proteomes:UP000190755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2014-VREF-268 {ECO:0000313|EMBL:AQY31992.1};
RA Kim H.M.;
RT "Non-typeable vancomycin-resistant E. faecium.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:OSP67575.1, ECO:0000313|Proteomes:UP000192991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EFM1CSP {ECO:0000313|EMBL:OSP67575.1,
RC ECO:0000313|Proteomes:UP000192991};
RA Sacramento A., Cerdeira L., Lincopan N.;
RT "Draft genome sequence of an Enterococcus faecium strain EFM1CSP.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:PHL21896.1, ECO:0000313|Proteomes:UP000224303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hp_5-7 {ECO:0000313|EMBL:PHL21896.1,
RC ECO:0000313|Proteomes:UP000224303};
RA Prianichniikov N.A., Glushchenko O.E., Malakhova M.V.;
RT "Draft genomes of the Enterococcus faecium isolated from human feces before
RT and after Helicobacter pylori eradication therapy.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:PQC74071.1, ECO:0000313|Proteomes:UP000239169}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVM N59891F {ECO:0000313|EMBL:PQC74071.1,
RC ECO:0000313|Proteomes:UP000239169};
RA Tyson G.;
RT "Whole-genome sequencing based characterization of antimicrobial resistance
RT in Enterococcus.";
RL Pathog. Dis. 0:0-0(2018).
RN [7] {ECO:0000313|EMBL:QDA39349.1, ECO:0000313|Proteomes:UP000308289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F17E0263 {ECO:0000313|EMBL:QDA39349.1,
RC ECO:0000313|Proteomes:UP000308289};
RA Li C., Zhao S.;
RT "Enterococcus faecium from chicken.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:TNW90060.1, ECO:0000313|Proteomes:UP000313746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F782 {ECO:0000313|EMBL:TNW90060.1,
RC ECO:0000313|Proteomes:UP000313746};
RA Novais C., Duarte B., Pereira A.P., Freitas A.R., Coque T.M.,
RA Hammerum A.M., Hasman H., Antunes P., Peixe L.;
RT "Identification of a 2CS-CHXT operon signature of chlorhexidine tolerant
RT Enterococcus faecium.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|Proteomes:UP000446843, ECO:0000313|Proteomes:UP000469871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VRECG10 {ECO:0000313|EMBL:KAB7618430.1,
RC ECO:0000313|Proteomes:UP000446843}, and VRECG27
RC {ECO:0000313|EMBL:KAB7578167.1, ECO:0000313|Proteomes:UP000469871};
RA Chilambi G.S., Nordstrom H.R., Evans D.R., Ferrolino J., Hayden R.T.,
RA Maron G.M., Vo A.N., Gilmore M.S., Wolf J., Rosch J.W., Van Tyne D.;
RT "Evolutionary dynamics of vancomycin-resistant Enterococcus faecium during
RT gastrointestinal tract colonization and bloodstream infection in
RT immunocompromised pediatric patients.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:MBX4223154.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EF215 {ECO:0000313|EMBL:MBX4223154.1};
RX PubMed=35150575; DOI=10.1093/jas/skac030;
RA Shridhar P.B., Amachawadi R.G., Tokach M., Patel I., Gangiredla J.,
RA Mammel M., Nagaraja T.G.;
RT "Whole genome sequence analyses-based assessment of virulence potential and
RT antimicrobial susceptibilities and resistance of Enterococcus faecium
RT strains isolated from commercial swine and cattle probiotic products.";
RL J. Anim. Sci. 100:skac030-skac030(2022).
RN [11] {ECO:0000313|EMBL:MDC4248752.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CP4 {ECO:0000313|EMBL:MDC4248752.1};
RA Hurtado R., Lima L., Sousa T., Jaiswal A.K., Tiwari S., Maturrano L.,
RA Brenig B., Azevedo V.;
RT "Draft genome sequences of Clostridium perfringens strains isolated from
RT Peru.";
RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:BDP58050.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JHP36 {ECO:0000313|EMBL:BDP58050.1};
RA Hashimoto Y., Suzuki M., Tomita H.;
RT "Analysis of enterococcal linear plasmids.";
RL Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the
CC cis-trans isomerization of proline imidic peptide bonds in
CC oligopeptides. {ECO:0000256|ARBA:ARBA00002388,
CC ECO:0000256|RuleBase:RU363019}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC Evidence={ECO:0000256|RuleBase:RU363019};
CC -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family.
CC {ECO:0000256|ARBA:ARBA00007365, ECO:0000256|RuleBase:RU363019}.
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DR EMBL; CP019992; AQY31992.1; -; Genomic_DNA.
DR EMBL; AP026586; BDP58050.1; -; Genomic_DNA.
DR EMBL; WEFP01000001; KAB7578167.1; -; Genomic_DNA.
DR EMBL; WEGG01000001; KAB7618430.1; -; Genomic_DNA.
DR EMBL; LRHK01000001; KWX17040.1; -; Genomic_DNA.
DR EMBL; JAIFOC010000084; MBX4223154.1; -; Genomic_DNA.
DR EMBL; JAMWMK010000024; MDC4248752.1; -; Genomic_DNA.
DR EMBL; NBVQ01000398; OSP67575.1; -; Genomic_DNA.
DR EMBL; PCGC01000010; PHL21896.1; -; Genomic_DNA.
DR EMBL; PTVN01000066; PQC74071.1; -; Genomic_DNA.
DR EMBL; CP040849; QDA39349.1; -; Genomic_DNA.
DR EMBL; LEQJ01000012; RBS29589.1; -; Genomic_DNA.
DR EMBL; VFCC01000073; TNW90060.1; -; Genomic_DNA.
DR RefSeq; WP_002287167.1; NZ_WVTH01000012.1.
DR STRING; 1352.AL014_15375; -.
DR GeneID; 66455015; -.
DR PATRIC; fig|1352.1358.peg.953; -.
DR OMA; TVKQTSW; -.
DR Proteomes; UP000070452; Unassembled WGS sequence.
DR Proteomes; UP000190755; Chromosome.
DR Proteomes; UP000192991; Unassembled WGS sequence.
DR Proteomes; UP000224303; Unassembled WGS sequence.
DR Proteomes; UP000239169; Unassembled WGS sequence.
DR Proteomes; UP000253144; Unassembled WGS sequence.
DR Proteomes; UP000308289; Chromosome.
DR Proteomes; UP000313746; Unassembled WGS sequence.
DR Proteomes; UP000446843; Unassembled WGS sequence.
DR Proteomes; UP000469871; Unassembled WGS sequence.
DR Proteomes; UP001061325; Chromosome.
DR Proteomes; UP001139644; Unassembled WGS sequence.
DR Proteomes; UP001141166; Unassembled WGS sequence.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR InterPro; IPR024936; Cyclophilin-type_PPIase.
DR InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR InterPro; IPR044666; Cyclophilin_A-like.
DR PANTHER; PTHR45625; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED; 1.
DR PANTHER; PTHR45625:SF4; PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00160; Pro_isomerase; 1.
DR PIRSF; PIRSF001467; Peptidylpro_ismrse; 2.
DR PRINTS; PR00153; CSAPPISMRASE.
DR SUPFAM; SSF50891; Cyclophilin-like; 1.
DR PROSITE; PS00170; CSA_PPIASE_1; 1.
DR PROSITE; PS50072; CSA_PPIASE_2; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|RuleBase:RU363019, ECO:0000313|EMBL:KWX17040.1};
KW Rotamase {ECO:0000256|RuleBase:RU363019}.
FT DOMAIN 23..192
FT /note="PPIase cyclophilin-type"
FT /evidence="ECO:0000259|PROSITE:PS50072"
SQ SEQUENCE 194 AA; 21267 MW; F8DA9EB07D34C55A CRC64;
MAFPQLDLKS EKGPKAVIKT NRGDITVQLF PELAPKTVQN FIELSKKGYY DGVIFHRVIP
DFMIQGGDPT GTGMGGESIY GESFEDEFSR ELFNLRGALS MANSGPNTNG SQFFIVNNTN
VPANMLGQLE GAGFPSEIIE AYKGGGTPWL DFRHTVFGHV LEGMDTVDEI ANVQRGPQDR
PVHDVVIETI EISE
//
