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Entry: A0A132P9J9_ENTFC
LinkDB: A0A132P9J9_ENTFC
Original site: A0A132P9J9_ENTFC 
ID   A0A132P9J9_ENTFC        Unreviewed;       416 AA.
AC   A0A132P9J9;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=ATP-dependent Clp protease ATP-binding subunit ClpX {ECO:0000256|HAMAP-Rule:MF_00175};
GN   Name=clpX {ECO:0000256|HAMAP-Rule:MF_00175,
GN   ECO:0000313|EMBL:BDP57462.1};
GN   ORFNames=AWT83_11235 {ECO:0000313|EMBL:KWX19015.1}, B1P95_09970
GN   {ECO:0000313|EMBL:OOL82290.1}, DPX30_08510
GN   {ECO:0000313|EMBL:RAQ24348.1}, EfmJHP36_19410
GN   {ECO:0000313|EMBL:BDP57462.1}, GBM44_08210
GN   {ECO:0000313|EMBL:KAB7617931.1}, GBM73_01380
GN   {ECO:0000313|EMBL:KAB7576042.1}, IQN16_07970
GN   {ECO:0000313|EMBL:UOC30735.1}, KT858_002000
GN   {ECO:0000313|EMBL:HBH6537733.1};
OS   Enterococcus faecium (Streptococcus faecium).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=1352 {ECO:0000313|EMBL:KWX19015.1, ECO:0000313|Proteomes:UP000070452};
RN   [1] {ECO:0000313|EMBL:KWX19015.1, ECO:0000313|Proteomes:UP000070452}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D344RRF x C68 {ECO:0000313|EMBL:KWX19015.1,
RC   ECO:0000313|Proteomes:UP000070452};
RA   Garcia-Solache M.A., Lebreton F., Mclaughlin R.E., Whiteaker J.D.,
RA   Gilmore M.S., Rice L.B.;
RT   "Molecular Mechanisms for transfer of large genomic segments between
RT   Enterococcus faecium strains.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:OOL82290.1, ECO:0000313|Proteomes:UP000191171}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LIM1759 {ECO:0000313|EMBL:OOL82290.1,
RC   ECO:0000313|Proteomes:UP000191171};
RA   Marchi A.P., Martins R.C., Marie S.K., Levin A.S., Costa S.F.;
RT   "Clonality and virulence of isolates of VRE in Hematopoietic Stem Cell
RT   Transplanted (HSCT) patients.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:HBH6537733.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=V2279 {ECO:0000313|EMBL:HBH6537733.1};
RX   PubMed=30286803;
RA   Souvorov A., Agarwala R., Lipman D.J.;
RT   "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL   Genome Biol. 19:153-153(2018).
RN   [4] {ECO:0000313|EMBL:RAQ24348.1, ECO:0000313|Proteomes:UP000249226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A20 {ECO:0000313|EMBL:RAQ24348.1,
RC   ECO:0000313|Proteomes:UP000249226};
RA   Zhou X., Chlebowicz M.A., Bathoorn E., Rosema S., Couto N., Lokate M.,
RA   Arends J.P., Friedrich A.W., Rossen J.W.;
RT   "Elucidating vancomycin-resistant Enterococcus faecium outbreaks: the role
RT   of clonal spread and movement of mobile genetic elements.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000446843, ECO:0000313|Proteomes:UP000469871}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VRECG10 {ECO:0000313|EMBL:KAB7617931.1,
RC   ECO:0000313|Proteomes:UP000446843}, and VRECG27
RC   {ECO:0000313|EMBL:KAB7576042.1, ECO:0000313|Proteomes:UP000469871};
RA   Chilambi G.S., Nordstrom H.R., Evans D.R., Ferrolino J., Hayden R.T.,
RA   Maron G.M., Vo A.N., Gilmore M.S., Wolf J., Rosch J.W., Van Tyne D.;
RT   "Evolutionary dynamics of vancomycin-resistant Enterococcus faecium during
RT   gastrointestinal tract colonization and bloodstream infection in
RT   immunocompromised pediatric patients.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:HBH6537733.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=V2279 {ECO:0000313|EMBL:HBH6537733.1};
RG   NCBI Pathogen Detection Project;
RL   Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:UOC30735.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BMT-1-1-10 {ECO:0000313|EMBL:UOC30735.1};
RX   PubMed=35134550;
RA   Both A., Kruse F., Mirwald N., Franke G., Christner M., Huang J.,
RA   Hansen J.L., Kroger N., Berneking L., Lellek H., Aepfelbacher M., Rohde H.;
RT   "Population dynamics in colonizing vancomycin-resistant Enterococcus
RT   faecium isolated from immunosuppressed patients.";
RL   J Glob Antimicrob Resist 28:267-273(2022).
RN   [8] {ECO:0000313|EMBL:BDP57462.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JHP36 {ECO:0000313|EMBL:BDP57462.1};
RA   Hashimoto Y., Suzuki M., Tomita H.;
RT   "Analysis of enterococcal linear plasmids.";
RL   Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-dependent specificity component of the Clp protease. It
CC       directs the protease to specific substrates. Can perform chaperone
CC       functions in the absence of ClpP. {ECO:0000256|HAMAP-Rule:MF_00175}.
CC   -!- SUBUNIT: Component of the ClpX-ClpP complex. Forms a hexameric ring
CC       that, in the presence of ATP, binds to fourteen ClpP subunits assembled
CC       into a disk-like structure with a central cavity, resembling the
CC       structure of eukaryotic proteasomes. {ECO:0000256|HAMAP-Rule:MF_00175}.
CC   -!- SIMILARITY: Belongs to the ClpX chaperone family. {ECO:0000256|HAMAP-
CC       Rule:MF_00175, ECO:0000256|PROSITE-ProRule:PRU01250}.
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DR   EMBL; AP026586; BDP57462.1; -; Genomic_DNA.
DR   EMBL; DAERWN010000043; HBH6537733.1; -; Genomic_DNA.
DR   EMBL; WEFP01000001; KAB7576042.1; -; Genomic_DNA.
DR   EMBL; WEGG01000001; KAB7617931.1; -; Genomic_DNA.
DR   EMBL; LRHK01000001; KWX19015.1; -; Genomic_DNA.
DR   EMBL; MVGJ01000054; OOL82290.1; -; Genomic_DNA.
DR   EMBL; QLYM01000001; RAQ24348.1; -; Genomic_DNA.
DR   EMBL; CP063555; UOC30735.1; -; Genomic_DNA.
DR   RefSeq; WP_002288492.1; NZ_WMGZ01000012.1.
DR   PATRIC; fig|1352.1358.peg.1555; -.
DR   OMA; HYKRVQA; -.
DR   Proteomes; UP000070452; Unassembled WGS sequence.
DR   Proteomes; UP000191171; Unassembled WGS sequence.
DR   Proteomes; UP000249226; Unassembled WGS sequence.
DR   Proteomes; UP000446843; Unassembled WGS sequence.
DR   Proteomes; UP000469871; Unassembled WGS sequence.
DR   Proteomes; UP000831402; Chromosome.
DR   Proteomes; UP000885039; Unassembled WGS sequence.
DR   Proteomes; UP001061325; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd19497; RecA-like_ClpX; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 6.20.220.10; ClpX chaperone, C4-type zinc finger domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00175; ClpX; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR004487; Clp_protease_ATP-bd_su_ClpX.
DR   InterPro; IPR046425; ClpX_bact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010603; Znf_CppX_C4.
DR   InterPro; IPR038366; Znf_CppX_C4_sf.
DR   NCBIfam; TIGR00382; clpX; 1.
DR   PANTHER; PTHR48102:SF7; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48102; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   Pfam; PF06689; zf-C4_ClpX; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SMART; SM00994; zf-C4_ClpX; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51902; CLPX_ZB; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00175};
KW   Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_00175};
KW   Hydrolase {ECO:0000313|EMBL:KWX19015.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00175}; Protease {ECO:0000313|EMBL:KWX19015.1};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00175}.
FT   DOMAIN          1..54
FT                   /note="ClpX-type ZB"
FT                   /evidence="ECO:0000259|PROSITE:PS51902"
FT   BINDING         13
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00175,
FT                   ECO:0000256|PROSITE-ProRule:PRU01250"
FT   BINDING         16
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00175,
FT                   ECO:0000256|PROSITE-ProRule:PRU01250"
FT   BINDING         35
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00175,
FT                   ECO:0000256|PROSITE-ProRule:PRU01250"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00175,
FT                   ECO:0000256|PROSITE-ProRule:PRU01250"
FT   BINDING         119..126
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00175"
SQ   SEQUENCE   416 AA;  46226 MW;  FAF751F14DE5EF50 CRC64;
     MYDNPSSNET VRCSFCGKTQ EEVKKIVAGP GVYICNECID LCKEIIDEEF YEEAVREFTE
     VPKPLEILEV LNNYVIGQDR AKRSLAVAVY NHYKRVNQQA QENTDDVELQ KSNICLIGPT
     GSGKTFLAQT LAKTLNVPFA IADATSLTEA GYVGEDVENI LLKLLQSADY NVELAEKGII
     YIDEIDKIAR KSENVSITRD VSGEGVQQAL LKILEGTVAS VPPQGGRKHP HQEFIQIDTT
     NILFIVGGAF DGIETIVKNR MGEKTIGFGT QNQKLSEDES VMQHIIPEDL LKFGLIPEFI
     GRLPVMAALE KLTTDDLVRI LTEPKNALVK QYQKLLSLDN TELEFEPEAL RAIAKKAIER
     NTGARGLRSI IEEIMMDVMF DIPSNENIEK VIITKEAAEL SGEPTVIYKD SEKKAG
//
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