ID A0A132PCD7_9MYCO Unreviewed; 961 AA.
AC A0A132PCD7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:KWX19989.1};
GN ORFNames=AFM11_32785 {ECO:0000313|EMBL:KWX19989.1};
OS Mycolicibacterium wolinskyi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX19989.1, ECO:0000313|Proteomes:UP000070612};
RN [1] {ECO:0000313|EMBL:KWX19989.1, ECO:0000313|Proteomes:UP000070612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC_01 {ECO:0000313|EMBL:KWX19989.1,
RC ECO:0000313|Proteomes:UP000070612};
RA de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA Limbago B.M., Noble-Wang J.;
RT "A draft genome sequence of Mycobacterium wolinskyi.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX19989.1}.
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DR EMBL; LGTW01000032; KWX19989.1; -; Genomic_DNA.
DR RefSeq; WP_067858297.1; NZ_LGTW01000032.1.
DR AlphaFoldDB; A0A132PCD7; -.
DR STRING; 59750.AWC31_32160; -.
DR PATRIC; fig|59750.3.peg.4886; -.
DR Proteomes; UP000070612; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000070612};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 863..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 891..914
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..382
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 608..931
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 939..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 961 AA; 104505 MW; 5261E5D726DE7C92 CRC64;
MTKPAHAQQN RPIVAHGLRI LAIPVIIFWV AFAVVVNVIA PQLEIVGEEH SAPMAPEDAP
SMIAMHRMGE NFHEFDSNST VMVVVEGQDA LGPDAHKYYD EIIRKLREDP EHIQHIQDFW
GDTLTAAGAQ SADGKASYVM LNLAGQQGQT LANEGVQKVR EVIEDTPAPP GVRAYVAGPA
ALTDDMHVIG NASLGKITLF TLVAIAIMLL IVYRSIITTL IQLVLTGVGL LASRGLISVL
ATHDVFGLTT FAGNILTMLA IAAATDYGIF LFGRYREARS AGEDRETAYY TTFRSVAPVI
IGSGLTIAGA TYCLSFARLP YFSTMGAPVA IGMLVVIASA VTMGPAVLFL GSKVGLYEAK
RAAKGRFWYK VGTAVVRWPA PILVASAFVV LIGVVAVPGY KPAYNDRWYL PTDAPVNVGF
AAADRHFTQA RMNPDILMVE SEHDMRNPAD MLVLDRVAKN ILHTEGIAMV QSITRPLGIP
IQHSSIPFQT SIQGQTSNLN LPFQREQLAN QLRMVDAMNV SIDILEQQYQ LSLQQTQLTQ
DSAAKSQELL EVTKKMRDNI ANFDDQFRPL RNYFYWEPHC FDIPMCSAAR SVFDALDGID
ELTDITGSVQ VNTDQLADLA PKLTALLPQT IASMKTSRDL SLASYNSQKA LLDQMQAMND
TALAMGQSFD DAKNDDLFYL PPEAFQNPDF ERGLKMFLSP DGKSARMFIT HQTDPATPDG
IARVNAERTA AQEGLKMSSL SDAKIFLGGV AATYKDMSDG ARYDLMIAVV SALTLIFMIM
LILTRSAVAA LVIVGTAASS IAASFGISVL LWQDLLGIHV HWLVMLMSVI ILLAVGSDYN
LLLVSRFKEE IHAGLKTGII RSMGGTGGVV TSAGLVFAAT MAAMLGSDLV VLAQMGSTIA
IGLLLDTLIV RSLLMPSIAT LLGRWFWWPQ VVYPRGDNHF RKPQRQQRDD DEDTAAIPVP
S
//
