ID A0A132PKE1_9MYCO Unreviewed; 765 AA.
AC A0A132PKE1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=isocitrate lyase {ECO:0000256|ARBA:ARBA00012909};
DE EC=4.1.3.1 {ECO:0000256|ARBA:ARBA00012909};
DE AltName: Full=Isocitrase {ECO:0000256|ARBA:ARBA00031022};
DE AltName: Full=Isocitratase {ECO:0000256|ARBA:ARBA00031921};
GN ORFNames=AFM11_20295 {ECO:0000313|EMBL:KWX22492.1};
OS Mycolicibacterium wolinskyi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX22492.1, ECO:0000313|Proteomes:UP000070612};
RN [1] {ECO:0000313|EMBL:KWX22492.1, ECO:0000313|Proteomes:UP000070612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC_01 {ECO:0000313|EMBL:KWX22492.1,
RC ECO:0000313|Proteomes:UP000070612};
RA de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA Limbago B.M., Noble-Wang J.;
RT "A draft genome sequence of Mycobacterium wolinskyi.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-threo-isocitrate = glyoxylate + succinate;
CC Xref=Rhea:RHEA:13245, ChEBI:CHEBI:15562, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:36655; EC=4.1.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00023531};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX22492.1}.
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DR EMBL; LGTW01000013; KWX22492.1; -; Genomic_DNA.
DR RefSeq; WP_067851936.1; NZ_LGTW01000013.1.
DR AlphaFoldDB; A0A132PKE1; -.
DR STRING; 59750.AWC31_11420; -.
DR PATRIC; fig|59750.3.peg.1393; -.
DR Proteomes; UP000070612; Unassembled WGS sequence.
DR GO; GO:0004451; F:isocitrate lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR CDD; cd00377; ICL_PEPM; 1.
DR Gene3D; 1.10.10.850; -; 1.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR InterPro; IPR039556; ICL/PEPM.
DR InterPro; IPR006254; Isocitrate_lyase.
DR InterPro; IPR018523; Isocitrate_lyase_ph_CS.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR21631:SF3; BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN; 1.
DR PANTHER; PTHR21631; ISOCITRATE LYASE/MALATE SYNTHASE; 1.
DR Pfam; PF00463; ICL; 2.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
DR PROSITE; PS00161; ISOCITRATE_LYASE; 1.
PE 4: Predicted;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:KWX22492.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070612}.
SQ SEQUENCE 765 AA; 85240 MW; FBCF7E24E0B4314A CRC64;
MATIEANAQT NSSIQQDFEH DVAATQAYFD SSRFDGIIRL YSARQVAEQR GTIPSDYPVA
REAATAFYPY LRELFAKKKS ITTFGPYSPG QAVVMKRMGI GGIYLGGWAT SAKGSISEDP
GPDLASYPLS QVPDEAAGLV RALLTADRNQ QYLRLKMSEE QRAATPAYDY RPFIIADADT
GHGGDPHVRN LIRRFVESGV PGYHIEDQRP GTKKCGHQGG KVLVPSDEQI KRLNTARFQL
DIMRVPGIIV ARTDAEAANL IDSRADERDQ PFLLGATNLK IPSYKSCFLA MVRHFYESGV
AELNGHLLYA LPEGEYSAAE EWLQRHGIMD AATEATAAWK QSGGSVDALF DKVESTFVDA
WQDDAGLNTY GEAVAELLEF REREGEPADM SAADWRAFAT RAPLYTAREK AKELGADVAW
DCERAKTPEG YYQVRGGIPY AIAKSLAAAP FADILWMETK TADLADAKQF ADAIHAEYPD
QMLAYNLSPS FNWDTTGMTD DEMRAFPEEL GKMGFVFNFI TYGGHQVDGV ACEEFATSLQ
QEGMLALARL QRKMRLVESP YRTPQTLVGG PRSDAALAAS SGRTATTKAM GKGSTQHQHL
AQTEVPKKLL EEWLALWSEH YQLPEKLRVQ LRPRRAGSDV LDLGIYGDGD EPLANVVVDP
IKDRHGRSIL TVRDQNTFSE QLRKKRLMDL IHLWLIHRFK AEIVYYVTPT EDNIYQTEKM
KTHGIFSDVY QEVGEIIVAD VNKPRIEELL APDRRALGRL IRKED
//
