ID A0A132PT88_9MYCO Unreviewed; 349 AA.
AC A0A132PT88;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=AFM11_04750 {ECO:0000313|EMBL:KWX25551.1};
OS Mycolicibacterium wolinskyi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX25551.1, ECO:0000313|Proteomes:UP000070612};
RN [1] {ECO:0000313|EMBL:KWX25551.1, ECO:0000313|Proteomes:UP000070612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC_01 {ECO:0000313|EMBL:KWX25551.1,
RC ECO:0000313|Proteomes:UP000070612};
RA de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA Limbago B.M., Noble-Wang J.;
RT "A draft genome sequence of Mycobacterium wolinskyi.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX25551.1}.
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DR EMBL; LGTW01000002; KWX25551.1; -; Genomic_DNA.
DR RefSeq; WP_067844615.1; NZ_LGTW01000002.1.
DR AlphaFoldDB; A0A132PT88; -.
DR STRING; 59750.AWC31_20395; -.
DR PATRIC; fig|59750.3.peg.2831; -.
DR Proteomes; UP000070612; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KWX25551.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070612}.
FT DOMAIN 15..335
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 349 AA; 37012 MW; ED12E8750B7AAF3E CRC64;
MTENEDVLVN VRNGVGILTL NRPKAINSLN EVMVAGIAEA LDAWEDDESV HTVLLTGAGE
RGLCAGGDVV AIYHSAKAGG ADARRFWYDE YLLNSRIGKY PKPYVALMDG IVMGGGVGVA
AHGSVRVATD TTKMAMPEVG IGFIPDVGGT YLLSRAPGAL GLHAALTGAP FSGADAIAMG
FADHFVPHDK LADFTEAIVD EGVDKALAAY AVEPPPSPLL AQRDWIDDCY SGDTVGDIVA
ALQNHEAGPA NDAANLIATR SPVSLAVTLE AVRRAAKLDT LEDVLRQEYR TSCASLRSHD
LVEGIRAQLV DKDRNPKWSP SSIAEVTQAD VDAYFVPADP DLTFEEEKK
//
