ID A0A132Z8T4_ENTFC Unreviewed; 830 AA.
AC A0A132Z8T4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=ATP-dependent Clp protease ATP-binding subunit {ECO:0000313|EMBL:HBA0732810.1, ECO:0000313|EMBL:OOL82888.1};
GN Name=clpC {ECO:0000313|EMBL:BDP55968.1};
GN ORFNames=B1P95_06775 {ECO:0000313|EMBL:OOL82888.1}, B4W81_04695
GN {ECO:0000313|EMBL:AQY31349.1}, CUN04_12930
GN {ECO:0000313|EMBL:PQC73700.1}, CUS10_08740
GN {ECO:0000313|EMBL:PQE62333.1}, DPX30_14290
GN {ECO:0000313|EMBL:RAQ25391.1}, EB44_02415
GN {ECO:0000313|EMBL:RBS67763.1}, EfmJHP36_04470
GN {ECO:0000313|EMBL:BDP55968.1}, GBM44_13680
GN {ECO:0000313|EMBL:KAB7618915.1}, GBM73_10015
GN {ECO:0000313|EMBL:KAB7577633.1}, IQN16_13770
GN {ECO:0000313|EMBL:UOC31780.1}, J8Y33_002713
GN {ECO:0000313|EMBL:HBA0732810.1}, KT858_002694
GN {ECO:0000313|EMBL:HBH6538384.1}, KYX88_11330
GN {ECO:0000313|EMBL:MBX4223399.1}, M3X98_13890
GN {ECO:0000313|EMBL:MDC4249095.1};
OS Enterococcus faecium (Streptococcus faecium).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1352 {ECO:0000313|EMBL:OOL82888.1, ECO:0000313|Proteomes:UP000191171};
RN [1] {ECO:0000313|EMBL:RBS67763.1, ECO:0000313|Proteomes:UP000252903}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=268EA1 {ECO:0000313|EMBL:RBS67763.1,
RC ECO:0000313|Proteomes:UP000252903};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A.M., Van Tyne D., Lebreton F., Saavedra J.T., Gilmore M.S.,
RA Manson Mcguire A., Clock S., Crupain M., Rangan U., Young S.,
RA Abouelleil A., Cao P., Chapman S.B., Griggs A., Priest M., Shea T.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus faecium 268EA1.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OOL82888.1, ECO:0000313|Proteomes:UP000191171}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LIM1759 {ECO:0000313|EMBL:OOL82888.1,
RC ECO:0000313|Proteomes:UP000191171};
RA Marchi A.P., Martins R.C., Marie S.K., Levin A.S., Costa S.F.;
RT "Clonality and virulence of isolates of VRE in Hematopoietic Stem Cell
RT Transplanted (HSCT) patients.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AQY31349.1, ECO:0000313|Proteomes:UP000190755}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2014-VREF-268 {ECO:0000313|EMBL:AQY31349.1};
RA Kim H.M.;
RT "Non-typeable vancomycin-resistant E. faecium.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:HBA0732810.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=V2124 {ECO:0000313|EMBL:HBA0732810.1}, and V2279
RC {ECO:0000313|EMBL:HBH6538384.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [5] {ECO:0000313|Proteomes:UP000239169, ECO:0000313|Proteomes:UP000240033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVM N52649 {ECO:0000313|EMBL:PQE62333.1,
RC ECO:0000313|Proteomes:UP000240033}, and CVM N59891F
RC {ECO:0000313|EMBL:PQC73700.1, ECO:0000313|Proteomes:UP000239169};
RA Tyson G.;
RT "Whole-genome sequencing based characterization of antimicrobial resistance
RT in Enterococcus.";
RL Pathog. Dis. 0:0-0(2018).
RN [6] {ECO:0000313|EMBL:RAQ25391.1, ECO:0000313|Proteomes:UP000249226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A20 {ECO:0000313|EMBL:RAQ25391.1,
RC ECO:0000313|Proteomes:UP000249226};
RA Zhou X., Chlebowicz M.A., Bathoorn E., Rosema S., Couto N., Lokate M.,
RA Arends J.P., Friedrich A.W., Rossen J.W.;
RT "Elucidating vancomycin-resistant Enterococcus faecium outbreaks: the role
RT of clonal spread and movement of mobile genetic elements.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Proteomes:UP000446843, ECO:0000313|Proteomes:UP000469871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VRECG10 {ECO:0000313|EMBL:KAB7618915.1,
RC ECO:0000313|Proteomes:UP000446843}, and VRECG27
RC {ECO:0000313|EMBL:KAB7577633.1, ECO:0000313|Proteomes:UP000469871};
RA Chilambi G.S., Nordstrom H.R., Evans D.R., Ferrolino J., Hayden R.T.,
RA Maron G.M., Vo A.N., Gilmore M.S., Wolf J., Rosch J.W., Van Tyne D.;
RT "Evolutionary dynamics of vancomycin-resistant Enterococcus faecium during
RT gastrointestinal tract colonization and bloodstream infection in
RT immunocompromised pediatric patients.";
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:HBA0732810.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=V2124 {ECO:0000313|EMBL:HBA0732810.1}, and V2279
RC {ECO:0000313|EMBL:HBH6538384.1};
RG NCBI Pathogen Detection Project;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:UOC31780.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BMT-1-1-10 {ECO:0000313|EMBL:UOC31780.1};
RX PubMed=35134550;
RA Both A., Kruse F., Mirwald N., Franke G., Christner M., Huang J.,
RA Hansen J.L., Kroger N., Berneking L., Lellek H., Aepfelbacher M., Rohde H.;
RT "Population dynamics in colonizing vancomycin-resistant Enterococcus
RT faecium isolated from immunosuppressed patients.";
RL J Glob Antimicrob Resist 28:267-273(2022).
RN [10] {ECO:0000313|EMBL:MBX4223399.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EF215 {ECO:0000313|EMBL:MBX4223399.1};
RX PubMed=35150575; DOI=10.1093/jas/skac030;
RA Shridhar P.B., Amachawadi R.G., Tokach M., Patel I., Gangiredla J.,
RA Mammel M., Nagaraja T.G.;
RT "Whole genome sequence analyses-based assessment of virulence potential and
RT antimicrobial susceptibilities and resistance of Enterococcus faecium
RT strains isolated from commercial swine and cattle probiotic products.";
RL J. Anim. Sci. 100:skac030-skac030(2022).
RN [11] {ECO:0000313|EMBL:MDC4249095.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CP4 {ECO:0000313|EMBL:MDC4249095.1};
RA Hurtado R., Lima L., Sousa T., Jaiswal A.K., Tiwari S., Maturrano L.,
RA Brenig B., Azevedo V.;
RT "Draft genome sequences of Clostridium perfringens strains isolated from
RT Peru.";
RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:BDP55968.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JHP36 {ECO:0000313|EMBL:BDP55968.1};
RA Hashimoto Y., Suzuki M., Tomita H.;
RT "Analysis of enterococcal linear plasmids.";
RL Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a stress-induced multi-chaperone system, it is
CC involved in the recovery of the cell from heat-induced damage, in
CC cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the
CC processing of protein aggregates. Protein binding stimulates the ATPase
CC activity; ATP hydrolysis unfolds the denatured protein aggregates,
CC which probably helps expose new hydrophobic binding sites on the
CC surface of ClpB-bound aggregates, contributing to the solubilization
CC and refolding of denatured protein aggregates by DnaK.
CC {ECO:0000256|ARBA:ARBA00025613}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; CP019992; AQY31349.1; -; Genomic_DNA.
DR EMBL; AP026586; BDP55968.1; -; Genomic_DNA.
DR EMBL; DADQVF010000097; HBA0732810.1; -; Genomic_DNA.
DR EMBL; DAERWN010000091; HBH6538384.1; -; Genomic_DNA.
DR EMBL; WEFP01000001; KAB7577633.1; -; Genomic_DNA.
DR EMBL; WEGG01000001; KAB7618915.1; -; Genomic_DNA.
DR EMBL; JAIFOC010000104; MBX4223399.1; -; Genomic_DNA.
DR EMBL; JAMWMK010000040; MDC4249095.1; -; Genomic_DNA.
DR EMBL; MVGJ01000031; OOL82888.1; -; Genomic_DNA.
DR EMBL; PTVN01000078; PQC73700.1; -; Genomic_DNA.
DR EMBL; PUBJ01000057; PQE62333.1; -; Genomic_DNA.
DR EMBL; QLYM01000001; RAQ25391.1; -; Genomic_DNA.
DR EMBL; LEQY01000014; RBS67763.1; -; Genomic_DNA.
DR EMBL; CP063555; UOC31780.1; -; Genomic_DNA.
DR RefSeq; WP_002289035.1; NZ_WVTH01000006.1.
DR STRING; 1352.AL014_12485; -.
DR GeneID; 66455688; -.
DR OMA; SKMMQGE; -.
DR Proteomes; UP000190755; Chromosome.
DR Proteomes; UP000191171; Unassembled WGS sequence.
DR Proteomes; UP000239169; Unassembled WGS sequence.
DR Proteomes; UP000240033; Unassembled WGS sequence.
DR Proteomes; UP000249226; Unassembled WGS sequence.
DR Proteomes; UP000252903; Unassembled WGS sequence.
DR Proteomes; UP000446843; Unassembled WGS sequence.
DR Proteomes; UP000469871; Unassembled WGS sequence.
DR Proteomes; UP000831402; Chromosome.
DR Proteomes; UP000870608; Unassembled WGS sequence.
DR Proteomes; UP000885039; Unassembled WGS sequence.
DR Proteomes; UP001061325; Chromosome.
DR Proteomes; UP001139644; Unassembled WGS sequence.
DR Proteomes; UP001141166; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 104; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Hydrolase {ECO:0000313|EMBL:OOL82888.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432}; Protease {ECO:0000313|EMBL:OOL82888.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 1..150
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 431..466
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
SQ SEQUENCE 830 AA; 92760 MW; 8183A6DFA8109496 CRC64;
MEELFTERAQ AVLEIAQEEA KRLKHQSVSS EHVLLALVVE QNGIAGKVLR EMDLNETEIY
EEIEHLIGYG GIRSYPKGVF LPYSPRMKQV FALASSEVKK TGSQKVGTEH ILMSLLKDES
IMATRIMINL GISLSKARQV LKQKMGLAGD SAGKGMNRRR NVNVQDKRQT PQGTPTLDSL
ARDLTKLAKE NKLDPVVGRS REVKRLIQIL SRRTKNNPVL VGEPGVGKTA IAEGLAQKII
LGEVPEDMQE KRLMMLDMGS LVAGTKYRGE FEDRMKKVID EIYNDGQVIL FIDELHTLIG
AGGAEGAIDA SNILKPALAR GELQTIGATT LDEYQKYIEK DSALERRFAR IQVDEPTPEE
AEVILQGLRT RYEEHHGVEI TDEAVRAAVN LSVRYITSRQ LPDKAIDLID ESAAKVRLDQ
TDHLTKSTVI KLEIDELVQE KEAAIQKQDF ENAAQLRRQE KALRKKLQKV SAIEAKQEQG
YSDRVTEEDV ATVVSEWTGV PLQQLEKKES ERLLELEGLL HERVVGQDEA VKAVSRAIRR
ARSGLKDPDR PIGSFMFLGP TGVGKTELAK ALSEVMFGSE DALIRVDMSE FMEKYSTSRL
IGSPPGYVGY DEGGQLTEKI RQKPYSVILL DEVEKAHPDV FNLLLQVLDD GHLTDSKGRK
VDFRNTIMIM TSNIGATQIR EEKNVGFNVQ DVTKDHKAMQ KRILEELKKA FRPEFLNRID
ETVVFHSLSK DEIHTIVQIM SKAIIKRLKE QDIQVKITPS AIDVIGKAGF DPEYGARPIR
RALQKEIEDR LSEALLGGEI RLGDHVTVGA SKGKITLNVR GPKKETVGSL
//