ID A0A133Q2A1_STALU Unreviewed; 733 AA.
AC A0A133Q2A1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=DNA internalization competence protein ComEC/Rec2-like protein {ECO:0000313|EMBL:KXA36996.1};
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:TBW70665.1};
GN ORFNames=EQ812_11435 {ECO:0000313|EMBL:TBW70665.1}, HMPREF3225_01949
GN {ECO:0000313|EMBL:KXA36996.1};
OS Staphylococcus lugdunensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=28035 {ECO:0000313|EMBL:KXA36996.1, ECO:0000313|Proteomes:UP000070063};
RN [1] {ECO:0000313|EMBL:KXA36996.1, ECO:0000313|Proteomes:UP000070063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MJR7738 {ECO:0000313|EMBL:KXA36996.1,
RC ECO:0000313|Proteomes:UP000070063};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:TBW70665.1, ECO:0000313|Proteomes:UP000293637}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E7 {ECO:0000313|EMBL:TBW70665.1,
RC ECO:0000313|Proteomes:UP000293637};
RA Williams M.R.;
RT "Quorum sensing between bacterial species on the skin protects against
RT epidermal injury in atopic dermatitis.";
RL Sci. Transl. Med. 0:0-0(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXA36996.1}.
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DR EMBL; LRQI01000079; KXA36996.1; -; Genomic_DNA.
DR EMBL; SCHB01000009; TBW70665.1; -; Genomic_DNA.
DR RefSeq; WP_002492921.1; NZ_SCHB01000009.1.
DR AlphaFoldDB; A0A133Q2A1; -.
DR PATRIC; fig|28035.7.peg.1974; -.
DR eggNOG; COG0658; Bacteria.
DR eggNOG; COG2333; Bacteria.
DR Proteomes; UP000070063; Unassembled WGS sequence.
DR Proteomes; UP000293637; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619:SF7; DNA INTERNALIZATION-RELATED COMPETENCE PROTEIN COMEC_REC2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 480..685
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 733 AA; 84499 MW; 835B9CBEDF091AB2 CRC64;
MFYIALAFLA GALWYSNFYI SLLIFVCLLY FVAIKRLTLI CFVLSIFISI LSYNIYSNLN
NSIKEQEIFN KHHEQISAFA HVTSAIVQNN DFIKGHLIVY NREYNYIYYI KKQDKGKYIH
KLKHYTCKIN GNLTHSESQN ALLVVKSIDF KSCKINSNPN LIQRHIDFIN NQIVHSGTKY
PYRIIALITG DTSQLNSTIK DAVKDIGIYH LLAVSGSHVA VITLIIYQSL VRWNTPLITI
KLLCVCILVI FAVETQFAPS ALRSIIAMII ILFKPKRTSL SGLNILAFVF LLLLIVQPDF
LYDIGFQFSF LISLFLILAQ PSIHHLSRLK AFFVITYIAQ LGALLIQIYH FNQVQWIGIL
TNLIFVPLYS FIYFPLTLFF FLISHIFINI KLLNFIIDYL FALHDQLVYF FLKLNNYQWN
IPQLSNMTIM FLSILVILSF IIFIHKKYIQ SLALIILSLI IVSYTAHSHV PTLTSFDVGQ
GDSLLYQTSR NHNILIDTGG KTAQNHSTIT HNIAKYHIIP SLKKRGVSKL DEVIITHPHV
DHMGELTYLM QHIRIKQLVI NSKSFPISQL NVIKKWCSKY NIILINADHI NTMHFDDSTI
QFLRSYIYDS QDKNEQSIVL LIKYHYKTIL LMGDASQRNE KILMKKYHLP HIDILKVGHH
GSKTSSSMIF LKQIQPKISI ISSGKHNKYH HPSIETIHKL LSIHSKLFNT QDKGEISVSL
DSKLTIKLNH GNH
//
