ID A0A133U373_9EURY Unreviewed; 323 AA.
AC A0A133U373;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=BPL/LPL catalytic domain-containing protein {ECO:0000259|PROSITE:PS51733};
GN ORFNames=AKJ61_04515 {ECO:0000313|EMBL:KXA88633.1};
OS candidate division MSBL1 archaeon SCGC-AAA259B11.
OC Archaea; Euryarchaeota; candidate division MSBL1.
OX NCBI_TaxID=1698260 {ECO:0000313|EMBL:KXA88633.1, ECO:0000313|Proteomes:UP000070184};
RN [1] {ECO:0000313|EMBL:KXA88633.1, ECO:0000313|Proteomes:UP000070184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC-AAA259B11 {ECO:0000313|EMBL:KXA88633.1};
RX PubMed=26758088; DOI=10.1038/srep19181;
RA Mwirichia R., Alam I., Rashid M., Vinu M., Ba-Alawi W., Anthony Kamau A.,
RA Kamanda Ngugi D., Goker M., Klenk H.P., Bajic V., Stingl U.;
RT "Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine
RT pools of the Red Sea.";
RL Sci. Rep. 6:19181-19181(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXA88633.1}.
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DR EMBL; LHXK01000096; KXA88633.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133U373; -.
DR Proteomes; UP000070184; Unassembled WGS sequence.
DR GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16442; BPL; 1.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00978; Bifunct_BirA; 1.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR030855; Bifunct_BirA.
DR InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR InterPro; IPR003142; BPL_C.
DR InterPro; IPR004143; BPL_LPL_catalytic.
DR InterPro; IPR013196; HTH_11.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00121; birA_ligase; 1.
DR PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR Pfam; PF02237; BPL_C; 1.
DR Pfam; PF03099; BPL_LplA_LipB; 1.
DR Pfam; PF08279; HTH_11; 1.
DR SUPFAM; SSF50037; C-terminal domain of transcriptional repressors; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000070184}.
FT DOMAIN 67..254
FT /note="BPL/LPL catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51733"
SQ SEQUENCE 323 AA; 36155 MW; 9F287C0815C0171E CRC64;
MDRPNTRWEI LRNLKKSETF LSGEELAKPL GVSRISVWKH IQNLKKMGYE IESKRGEGYK
LLEPPDKLLP PEILPLDTEI VGREIIHYEE VKSTNLKMRE KSEEEEGLII LAERQTEGKG
RLGRNWKSPK GGIWMSVLLK PNIPPVETPL LTMISSTSVF ESLQEIGIEG SIKWPNDVLV
DGEKICGILT EMDAEMGALN YVIIGIGLNV NFDKNELPDT GATTVQSILE EKVDRKALTG
SIITNLDKWY RKLKKNSKEE ILDSWRANSH NLGRKVDVEM VTGESFTGTA VDFTDTGGLV
VKGENGSERT FLSGDVTLSS DSR
//
