ID A0A133V290_9EURY Unreviewed; 597 AA.
AC A0A133V290;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Probable translation initiation factor IF-2 {ECO:0000256|HAMAP-Rule:MF_00100};
GN Name=infB {ECO:0000256|HAMAP-Rule:MF_00100};
GN ORFNames=AKJ42_00380 {ECO:0000313|EMBL:KXB00553.1};
OS candidate division MSBL1 archaeon SCGC-AAA261C02.
OC Archaea; Euryarchaeota; candidate division MSBL1.
OX NCBI_TaxID=1698272 {ECO:0000313|EMBL:KXB00553.1, ECO:0000313|Proteomes:UP000070520};
RN [1] {ECO:0000313|EMBL:KXB00553.1, ECO:0000313|Proteomes:UP000070520}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC-AAA261C02 {ECO:0000313|EMBL:KXB00553.1};
RX PubMed=26758088; DOI=10.1038/srep19181;
RA Mwirichia R., Alam I., Rashid M., Vinu M., Ba-Alawi W., Anthony Kamau A.,
RA Kamanda Ngugi D., Goker M., Klenk H.P., Bajic V., Stingl U.;
RT "Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine
RT pools of the Red Sea.";
RL Sci. Rep. 6:19181-19181(2016).
CC -!- FUNCTION: Function in general translation initiation by promoting the
CC binding of the formylmethionine-tRNA to ribosomes. Seems to function
CC along with eIF-2. {ECO:0000256|ARBA:ARBA00024852, ECO:0000256|HAMAP-
CC Rule:MF_00100, ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|HAMAP-Rule:MF_00100,
CC ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00100}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB00553.1}.
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DR EMBL; LHXW01000002; KXB00553.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133V290; -.
DR PATRIC; fig|1698272.3.peg.82; -.
DR Proteomes; UP000070520; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd16266; IF2_aeIF5B_IV; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR HAMAP; MF_00100_A; IF_2_A; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR004544; TF_aIF-2_arc.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00491; aIF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|HAMAP-Rule:MF_00100};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_00100}; Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00100};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00100}; Reference proteome {ECO:0000313|Proteomes:UP000070520}.
FT DOMAIN 6..224
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT BINDING 15..22
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00100"
FT BINDING 79..83
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00100"
SQ SEQUENCE 597 AA; 66543 MW; D159C0181EB4F659 CRC64;
MPEQKVRQPI ISVLGHVDHG KTLLLDKIRG TTVMDREAGA ITQHIGATEV PTKTVEDICG
KLLERFSTGV ELPGLLFVDT PGHEAFTNLR RRGGTLADLA ILVVDVTEGF KPQTIESIGH
LKRNKTPFVL AANKMDLLPG WNPTNDACFI DTFPNQNDRV QEELDEKIYE IVGDLHDHGF
QAERFDRIED FKKQVGIVPT SAKTGEGIPE LLAVLTGLAQ RFLKKELSVE VKGPGRGVVL
EIKKERGLGK TADVIIYDGT LKKKDEIAIG GLEEAITTKV RALLQPKPLD EIRDPQDKFR
HVNEVTAAAG VKIAAPDIEG IIAGAPVWII ETTEEARELQ RQVRKEIESL RIQADVNGVV
VKADTIGSLE ALEGQLIEQE IPIRRADIGD VSRRDVIEAS AVSDDDPLLA VILAFNVEIL
SHAQEEAKRR NIKIVSDDVI YRLIEDYQEW VEEERERIRV EKLREFIRPG KFAIKQGYVF
RRSNPAIVGV DVLGGVLKPG FPVMNTDGEQ VGTIREIQKE RKTLQEAKTG DELALSIEGP
IVDRHIKEGD VLYVDVPRDQ MIELKRDLKD MLSEDELGVM SEIIDIKQKE DPTYGVM
//
