ID A0A133V641_9EURY Unreviewed; 447 AA.
AC A0A133V641;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=AKJ44_01935 {ECO:0000313|EMBL:KXB01903.1};
OS candidate division MSBL1 archaeon SCGC-AAA261F17.
OC Archaea; Euryarchaeota; candidate division MSBL1.
OX NCBI_TaxID=1698274 {ECO:0000313|EMBL:KXB01903.1, ECO:0000313|Proteomes:UP000070035};
RN [1] {ECO:0000313|EMBL:KXB01903.1, ECO:0000313|Proteomes:UP000070035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC-AAA261F17 {ECO:0000313|EMBL:KXB01903.1};
RX PubMed=26758088; DOI=10.1038/srep19181;
RA Mwirichia R., Alam I., Rashid M., Vinu M., Ba-Alawi W., Anthony Kamau A.,
RA Kamanda Ngugi D., Goker M., Klenk H.P., Bajic V., Stingl U.;
RT "Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine
RT pools of the Red Sea.";
RL Sci. Rep. 6:19181-19181(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB01903.1}.
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DR EMBL; LHXY01000022; KXB01903.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133V641; -.
DR Proteomes; UP000070035; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR Pfam; PF13186; SPASM; 1.
DR SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000070035};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 121..322
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 50124 MW; E7D1CB09F0CCEF10 CRC64;
MMGIRLTGDG SKGKGDQGSC RETVGDVVAR QENFGGIVFD QRNGLMLELD REAFFFLLNY
DKTSNYSEML RLLEREFRRS FSLGELWRLS KKLFGLGIMS TSLSSQSKEF SESNWPKTEY
LSAPETVHLA VTYRCNLECS CCYVEGGDCS EDEMSLGQIR RLVDKLSELR VFQIAIGGGE
PFLRSDLPEI VDVIRRRGII PNITTNGTLL TRTTLEEIAD EIGRLKISFE SGDISKKIEP
VNSAGVPFGI NLILTRENIA RIEDILSLCS RLGAKDVTLL RPKPSSRDLE WWRAHRPQPA
EYVRLGEKLV KLANKFGDIQ ITVDCALSFL MKGVSLTVLT YHGVYGCSAG ERFLFIAPNA
DVYPCSQFTD TDHLIGNALK EDFADLWNES PVLTKFRKFR ENDAFSKTSC GKCRNVINCG
GCRVITRENQ GDFYGRDPAC SQGVRRG
//
