ID A0A133VFW2_9EURY Unreviewed; 442 AA.
AC A0A133VFW2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KXB05323.1};
GN ORFNames=AKJ50_01235 {ECO:0000313|EMBL:KXB05323.1};
OS candidate division MSBL1 archaeon SCGC-AAA382A13.
OC Archaea; Euryarchaeota; candidate division MSBL1.
OX NCBI_TaxID=1698279 {ECO:0000313|EMBL:KXB05323.1, ECO:0000313|Proteomes:UP000070311};
RN [1] {ECO:0000313|EMBL:KXB05323.1, ECO:0000313|Proteomes:UP000070311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC-AAA382A13 {ECO:0000313|EMBL:KXB05323.1};
RX PubMed=26758088; DOI=10.1038/srep19181;
RA Mwirichia R., Alam I., Rashid M., Vinu M., Ba-Alawi W., Anthony Kamau A.,
RA Kamanda Ngugi D., Goker M., Klenk H.P., Bajic V., Stingl U.;
RT "Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine
RT pools of the Red Sea.";
RL Sci. Rep. 6:19181-19181(2016).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the malic enzymes family.
CC {ECO:0000256|ARBA:ARBA00008785}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB05323.1}.
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DR EMBL; LHYD01000019; KXB05323.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133VFW2; -.
DR PATRIC; fig|1698279.3.peg.105; -.
DR Proteomes; UP000070311; Unassembled WGS sequence.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR001891; Malic_OxRdtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR PIRSF; PIRSF000106; ME; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000070311}.
FT DOMAIN 21..157
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 169..398
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 442 AA; 48185 MW; 4C4B3A59943500FA CRC64;
MLSEKEPNAT EVSNKYHKYY KGKFAIQSKV PVREEKADYD FSIWYTPGVA EPCKQIDKDK
QNVYEYTNKG NMVAVVSDGT RILGLGSLGP EAAMPVMEGK SLLFKYLGNI DAVPVCIDTK
DEDEIVDFVE KLQPTFGGIN LEDIEKPKCF KVLEKLRESL DIPVWHDDQQ GTALVSLAGL
FGGLKFVGKK PEEIKLVIGG AGAAGINNAK YAITGGVKPE NVKIVDSKGI ISTSRDDIEE
GTYKHEWAKR TNPENIEGDM KDALNGADAC ISATVPGPGI ITKEMVSGMA DDSILFAEAN
PVPEILPEDA KEAGVRIVGT GRSDYPNQVN NSLGFPAVFR GALEVHATGI TDEMCGTAAY
AIAERAEEIG LREDFVIPSM NDKEMYVKEA LAVAKKAMEQ GIARKKVGEK ELEERIRTKL
DSAKNATQLL MQEGIIPDFP SD
//
