ID A0A133VMA5_9EURY Unreviewed; 803 AA.
AC A0A133VMA5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Zinc-hook domain-containing protein {ECO:0000259|PROSITE:PS51131};
GN ORFNames=AKJ54_00110 {ECO:0000313|EMBL:KXB07541.1};
OS candidate division MSBL1 archaeon SCGC-AAA382K21.
OC Archaea; Euryarchaeota; candidate division MSBL1.
OX NCBI_TaxID=1698283 {ECO:0000313|EMBL:KXB07541.1, ECO:0000313|Proteomes:UP000070504};
RN [1] {ECO:0000313|EMBL:KXB07541.1, ECO:0000313|Proteomes:UP000070504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC-AAA382K21 {ECO:0000313|EMBL:KXB07541.1};
RX PubMed=26758088; DOI=10.1038/srep19181;
RA Mwirichia R., Alam I., Rashid M., Vinu M., Ba-Alawi W., Anthony Kamau A.,
RA Kamanda Ngugi D., Goker M., Klenk H.P., Bajic V., Stingl U.;
RT "Metabolic traits of an uncultured archaeal lineage -MSBL1- from brine
RT pools of the Red Sea.";
RL Sci. Rep. 6:19181-19181(2016).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB07541.1}.
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DR EMBL; LHYH01000002; KXB07541.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133VMA5; -.
DR Proteomes; UP000070504; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 1.20.1480.30; Designed four-helix bundle protein; 1.
DR Gene3D; 1.10.287.510; Helix hairpin bin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR013134; Zn_hook_RAD50.
DR PANTHER; PTHR32114; ABC TRANSPORTER ABCH.3; 1.
DR PANTHER; PTHR32114:SF2; ABC TRANSPORTER ABCH.3; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF04423; Rad50_zn_hook; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF75712; Rad50 coiled-coil Zn hook; 1.
DR PROSITE; PS51131; ZN_HOOK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00471}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000070504};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00471}.
FT DOMAIN 366..463
FT /note="Zinc-hook"
FT /evidence="ECO:0000259|PROSITE:PS51131"
FT REGION 309..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 411
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
FT BINDING 414
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00471"
SQ SEQUENCE 803 AA; 93738 MW; A8B7B79850CC6EEC CRC64;
MLWRKIMITR VKLENWKSHD TTEMEFSEGT NVLVGIMGSG KSAVLDGITY GLFGTVPAVR
NRRITLDDLI RKRPVKEDTA KVEVEFTDPQ GASYIVKRKI ERGKGTTFAE IRQKEGELID
KPNSTSVTEH VTTLLQVDFD FYRRMIYAEQ NQLDLFLTLE PRERRRRVDE LLKINKFENA
RKNVVTIVNR LKDRLEDREE ELRELREDEE IEALPSLEEE LKETENERQE LAEKKEQIKP
EIKKVEERLD KLEKVKNEIE DLSKKIESVK ARIETLNQQI AKDKEKLGKH VDTTLEDLEG
RVEDLKEKLK EKKEEAERLE SEASSSTAEV SKLKTEKKSL KNEIEDIKEK INEKENSQEE
LEEIDVPKLS EELESLKDNR EDLRDESSGL KARINDLRNS LEELRVAEST CPVCGRPLKP
EKKSKLIQER NRRLEDLETK LSNVREEIKS VENDISDMNK LHEKVTDLRT DIEDLPNLRS
KLDELEKNIE NKSKELSEAS DKSEEVNENL KNVKREVERI REDFEESKKL RESREDLKSS
SKEKEKAEKE RKALQSELEE REKEFDEDLV RDLKNRNQEL IKKQEHFKTR VNEIDKLIEQ
KKKLVENIRE KKRRLERREA EVEILRGSIS SLNKIKRALS ESQTALREQV IEAVNAMMND
IWQDIYPYGD FRRIRLSIEE SGRTSDYELQ LMDSSGAWVP VEGVVSGGER TCASLTLRIA
FAVVLAPGLS WLVLDEPTHN LDSEGIEYLS EVLRGGIPKF VNQLLLITHE KQLESAVSGN
LHRFFRDKSQ DGPTEVRRVY EED
//
