ID   A0A133YHA8_9FIRM        Unreviewed;       787 AA.
AC   A0A133YHA8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=HDIG domain protein {ECO:0000313|EMBL:KXB42582.1};
GN   ORFNames=HMPREF1872_00270 {ECO:0000313|EMBL:KXB42582.1};
OS   Amygdalobacter nucleatus.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Amygdalobacter.
OX   NCBI_TaxID=3029274 {ECO:0000313|EMBL:KXB42582.1, ECO:0000313|Proteomes:UP000070080};
RN   [1] {ECO:0000313|Proteomes:UP000070080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA00274 {ECO:0000313|Proteomes:UP000070080};
RA   Mitreva M., Pepin K.H., Mihindukulasuriya K.A., Fulton R., Fronick C.,
RA   O'Laughlin M., Miner T., Herter B., Rosa B.A., Cordes M., Tomlinson C.,
RA   Wollam A., Palsikar V.B., Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXB42582.1}.
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DR   EMBL; LSCV01000002; KXB42582.1; -; Genomic_DNA.
DR   RefSeq; WP_066712743.1; NZ_KQ959565.1.
DR   AlphaFoldDB; A0A133YHA8; -.
DR   STRING; 1497955.HMPREF1872_00270; -.
DR   PATRIC; fig|1497955.3.peg.254; -.
DR   OrthoDB; 9806952at2; -.
DR   Proteomes; UP000070080; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR   InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   Pfam; PF07698; 7TM-7TMR_HD; 1.
DR   Pfam; PF07697; 7TMR-HDED; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070080};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        398..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        461..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        488..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        520..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          575..721
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   787 AA;  88433 MW;  27AC4DF738366DA2 CRC64;
     MRLNFHRLNK FLRCTLASVL LIVFLLFVYW QSLPRKYDLH IGQVSPYDIT ASHNLIDKNA
     TRLKAISEAS AVSPIFTRSE AMSAQCLAKL DEYLSILYNL RLPVWQDYAE VSGEKLKDNL
     VNALADFNAI FPDADRDVAE NKAETEATEA TTIETATANQ EKGVEPSSSV AKDAESALAK
     NVKPEVKVLT EAEKKAIQAK VEASYPKNTE LKELAKRISS LSKNKGIYIA ETYAHLLAEA
     EPSVFMSLII ELRTTAKSIM SQDLNKEKLD IAITHKSAKL VETVKNYTEL YSVTAPILRS
     ILAANLRYDA QVTREARNTV YERAMANPIQ IHRGTRIVNY NDVISESQYE NLKQLGLLKD
     ADQNYQYLFV LLAMAFVCLG LSVVYLSRRT NDYSAARGSN FILTTSAVAV IICSLYTAKI
     STFLLPIPFF ILISLIYFNT RDSLFLTMVL ISFLSILSDN TVAHFVGYTV AALIMLLIMS
     YSKQKNNYLL LIIASSVAMI IGGAFYAVFE YQTLMEAIKV LGFCLLNGLL CALVTIGVVP
     LFDFTFAAVS PMRLVALAQP DAPLMKRLFM EALGTYQHSM MVANLAETAA EAVGANTLLC
     RVGAYYHDIG KLEQPLMFTE NQDDYNPHDD LQPESSYQII TRHVLMGQKM AKRYRLPQAL
     QNIIKEHHGT TVLFYFYKKA EKEHQKLNLP PVDKANWRYP WQTPSSKEAA IVMLADSLEA
     AMKSTGYRTV QQVEEMARKI VHDKNSQDQL IHSGLSYQDV EDILQAFKRV YAGVFKERVK
     YPDVSKS
//