ID A0A133YHE0_9FIRM Unreviewed; 763 AA.
AC A0A133YHE0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=DNA gyrase/topoisomerase IV, A subunit {ECO:0000313|EMBL:KXB42567.1};
GN ORFNames=HMPREF1872_00253 {ECO:0000313|EMBL:KXB42567.1};
OS Amygdalobacter nucleatus.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Amygdalobacter.
OX NCBI_TaxID=3029274 {ECO:0000313|EMBL:KXB42567.1, ECO:0000313|Proteomes:UP000070080};
RN [1] {ECO:0000313|Proteomes:UP000070080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KA00274 {ECO:0000313|Proteomes:UP000070080};
RA Mitreva M., Pepin K.H., Mihindukulasuriya K.A., Fulton R., Fronick C.,
RA O'Laughlin M., Miner T., Herter B., Rosa B.A., Cordes M., Tomlinson C.,
RA Wollam A., Palsikar V.B., Mardis E.R., Wilson R.K.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB42567.1}.
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DR EMBL; LSCV01000002; KXB42567.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133YHE0; -.
DR STRING; 1497955.HMPREF1872_00253; -.
DR PATRIC; fig|1497955.3.peg.239; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000070080; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR PANTHER; PTHR43493:SF1; DNA TOPOISOMERASE 4 SUBUNIT A; 1.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KXB42567.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070080};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 37..485
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
SQ SEQUENCE 763 AA; 85267 MW; FB855DBDBCE2FFAD CRC64;
MKRQHKEHTS AKKQQSLAAL PEELSYLADE AGSISTERIS QTLQNNYMPY AMSVIISRAI
PEIDGFKPAH RKLLYTMYKS GLLTGPRSKS ANVVGATMKL NPHGDQAIYD TLVRLTRGNE
SLLHPYIDSK GNMGKQYSKD MQSAAPRYTE VKLDPIAALL FRGIDEDMVD FVPNYDGTMQ
EPTLLPAAFP SVLVNANQGI AVGMASNICS FNLKEVCEAT IAYIDDPTCD LLTYMPAPDF
ASGANLIYDQ AKMREIYNSG RGSFKLRATY TINKAENCIE IRKIPYTSTI EGIIDKLAEL
VKTNKIKEIV DVRDETDING LCITIDYKKS ADPEQLMQKL FSLSELENTF PCNFNLLING
RPVVLGIRGI ISEWLVFRRN CVKRSLLYKE AKLKDKLHLL AALAEVLLDV DKAIKIIKNT
ELDSEVVPNL AAAFRIDQAQ AEYVAEIKLR QLNKEHLLKR LAEKDKLQAE LADIAATLAS
TTKLDHLIAQ ELKEIAKTYG KERKTKLISA DSVVTVKESD FIADFNLKAF LTRDGYLKKI
ALTSLRSTAE LKLKDNDAII GMMEGSNKQE VLLFSSLGNL YKLKLADLND DKPSDWGTYL
PNLLDLASDE KIVGLVITSD YQGEIAVAYA DGRVSRADLS NYETKQNRKK LVKAVSSHSP
VVAVYYLTDE MLNDPATSDF IMISDQQRAI LFNINLVNKK TTRSNRGDQV LKLKKQAKVI
SFLPLSSMSD PSEWQRHRSL KLCTTGITLK SADLGERQVT LFK
//
