ID A0A133Z054_9ACTN Unreviewed; 251 AA.
AC A0A133Z054;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=thiamine diphosphokinase {ECO:0000256|ARBA:ARBA00013245};
DE EC=2.7.6.2 {ECO:0000256|ARBA:ARBA00013245};
GN ORFNames=HMPREF3190_01384 {ECO:0000313|EMBL:KXB48822.1};
OS Coriobacteriales bacterium DNF00809.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales.
OX NCBI_TaxID=1588753 {ECO:0000313|EMBL:KXB48822.1, ECO:0000313|Proteomes:UP000070490};
RN [1] {ECO:0000313|Proteomes:UP000070490}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DNF00809 {ECO:0000313|Proteomes:UP000070490};
RA Mitreva M., Pepin K.H., Mihindukulasuriya K.A., Fulton R., Fronick C.,
RA O'Laughlin M., Miner T., Herter B., Rosa B.A., Cordes M., Tomlinson C.,
RA Wollam A., Palsikar V.B., Mardis E.R., Wilson R.K.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB48822.1}.
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DR EMBL; LSCX01000054; KXB48822.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A133Z054; -.
DR STRING; 1588753.HMPREF3190_01384; -.
DR PATRIC; fig|1588753.3.peg.1356; -.
DR OrthoDB; 9804377at2; -.
DR Proteomes; UP000070490; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0030975; F:thiamine binding; IEA:InterPro.
DR GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0006772; P:thiamine metabolic process; IEA:InterPro.
DR CDD; cd07995; TPK; 1.
DR Gene3D; 3.40.50.10240; Thiamin pyrophosphokinase, catalytic domain; 1.
DR InterPro; IPR006282; Thi_PPkinase.
DR InterPro; IPR007373; Thiamin_PyroPKinase_B1-bd.
DR InterPro; IPR007371; TPK_catalytic.
DR InterPro; IPR036759; TPK_catalytic_sf.
DR NCBIfam; TIGR01378; thi_PPkinase; 1.
DR PANTHER; PTHR41299; THIAMINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR41299:SF1; THIAMINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF04265; TPK_B1_binding; 1.
DR Pfam; PF04263; TPK_catalytic; 1.
DR SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KXB48822.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000070490};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 60..153
FT /note="Thiamin pyrophosphokinase catalytic"
FT /evidence="ECO:0000259|Pfam:PF04263"
FT DOMAIN 180..233
FT /note="Thiamin pyrophosphokinase thiamin-binding"
FT /evidence="ECO:0000259|Pfam:PF04265"
SQ SEQUENCE 251 AA; 27771 MW; 135365D55A7EB151 CRC64;
MFQQRNAVVV YHASIMLVSY WYKIKPTEGT TMSVCALVAA SECNEEHFKT LFDAGFFDEV
YAVDAGFVYT KACGCDPDLI IGDFDSLGYV PDAQRTAEYP CDKDETDLEL AFDRARMRRF
DTIYVYGALG GRIDMTLATM QTIVRYAQLG ITVHVIGLAE QLDVVIGPDA LELPAHKDGI
VSVFSASDVC EGVIERGLKY AFNDERITNT TVRGISNEMT GLPAVIGLEK GVLWVFHPID
MPELPCTPHT D
//
