ID   A0A133ZCN3_9ACTN        Unreviewed;       881 AA.
AC   A0A133ZCN3;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=ComEC/Rec2-like protein {ECO:0000313|EMBL:KXB53200.1};
GN   ORFNames=HMPREF3190_00539 {ECO:0000313|EMBL:KXB53200.1};
OS   Coriobacteriales bacterium DNF00809.
OC   Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales.
OX   NCBI_TaxID=1588753 {ECO:0000313|EMBL:KXB53200.1, ECO:0000313|Proteomes:UP000070490};
RN   [1] {ECO:0000313|Proteomes:UP000070490}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DNF00809 {ECO:0000313|Proteomes:UP000070490};
RA   Mitreva M., Pepin K.H., Mihindukulasuriya K.A., Fulton R., Fronick C.,
RA   O'Laughlin M., Miner T., Herter B., Rosa B.A., Cordes M., Tomlinson C.,
RA   Wollam A., Palsikar V.B., Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXB53200.1}.
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DR   EMBL; LSCX01000015; KXB53200.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A133ZCN3; -.
DR   STRING; 1588753.HMPREF3190_00539; -.
DR   Proteomes; UP000070490; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070490};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        247..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        359..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        508..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          192..451
FT                   /note="ComEC/Rec2-related protein"
FT                   /evidence="ECO:0000259|Pfam:PF03772"
FT   REGION          836..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   881 AA;  97041 MW;  1D18A7B8CA89DDAC CRC64;
     MLLIGVIGAS GVILALMHTK AVWFFIVGSI LAFVFSLFSL VLYAQSLHQL ADVPWDATEN
     YVVHVEKDAQ TKGAQARTLV TLYNEDGTLV LPSGLKCVCD MPVLDALVLT QSSMTVKGTL
     RALKPNEYQR FISSHVVARL TVTHADTPRY RGLWAPLFML REQLIDKLVK RQTPESSLIA
     VITCGFRNSL ANFDTYDVFK QSGLAHLIAV SGAHMSLLCG FISSVLGKFH VAKRMVCTLM
     ISFMGMYLLI AGFPISALRA AAMSCLALGA YFAKRRSNAL QALCICIIVF LVCDTTCALS
     LSFALSALAT AGILMFSRLF EWLIKRYVPF LKCIASILSV SVAALIPTQA LSCAFFETLS
     LYSLCANILA APFFIILCCG GILSLLLSCC APFIADFVFI GVEACAFVLV SSLKVLNTAP
     FACVHVSISV PGALACSVCV SGIIYAVWYI KTNPHAQNRL RCCSNKQMNG VFSRVAHVDL
     LSTLLSRVHA GVKKSEHMLP SKHSTLRMRI MVAAICCFVW SVCAVYVCNR EPPLYRLTAF
     SYDKQCCYLL TSQSEQTLIN VTSPVAPLID FLKRHNVEML DYVVLSDDNP AHYSALLELY
     DAIPYQALAS FVENPEQMQH ADTFASFLGH RDTQYQVNKV SADFSTPMRV YRARDDTTNK
     VSFTSSNLLT FSNVIAYVKT RGVTYQHLRY DDTLRCGNAE LRVVWPHRVH ETYRNSDTLA
     LTLRLLTDAE KSSLPAQTSN ANHSPAKTHD TISPSAKTNM AGTHALASRD AHVSTPVHMG
     KHVSLIAPFL SFEEITDILL ERNSYDMELA CIAPGVCDDP FTAGELHARV YVLSPPQTPL
     DSSTNKNSQS QYTPTSYDMQ LVREVSVSFT KNSMRVDHAP P
//