ID   A0A134AH78_9FIRM        Unreviewed;       313 AA.
AC   A0A134AH78;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Pseudouridine synthase, RluA family {ECO:0000313|EMBL:KXB67077.1};
GN   ORFNames=HMPREF1863_00803 {ECO:0000313|EMBL:KXB67077.1};
OS   Peptoniphilus coxii.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Peptoniphilus.
OX   NCBI_TaxID=755172 {ECO:0000313|EMBL:KXB67077.1, ECO:0000313|Proteomes:UP000070442};
RN   [1] {ECO:0000313|Proteomes:UP000070442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DNF00729 {ECO:0000313|Proteomes:UP000070442};
RA   Mitreva M., Pepin K.H., Mihindukulasuriya K.A., Fulton R., Fronick C.,
RA   O'Laughlin M., Miner T., Herter B., Rosa B.A., Cordes M., Tomlinson C.,
RA   Wollam A., Palsikar V.B., Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000256|ARBA:ARBA00010876}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXB67077.1}.
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DR   EMBL; LSDG01000023; KXB67077.1; -; Genomic_DNA.
DR   RefSeq; WP_068367480.1; NZ_KQ960172.1.
DR   AlphaFoldDB; A0A134AH78; -.
DR   STRING; 755172.HMPREF1863_00803; -.
DR   PATRIC; fig|755172.3.peg.772; -.
DR   OrthoDB; 9807829at2; -.
DR   Proteomes; UP000070442; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IEA:UniProt.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR21600:SF92; 21S RRNA PSEUDOURIDINE(2819) SYNTHASE; 1.
DR   PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000070442};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182}.
FT   DOMAIN          13..73
FT                   /note="RNA-binding S4"
FT                   /evidence="ECO:0000259|SMART:SM00363"
SQ   SEQUENCE   313 AA;  36137 MW;  BCFD426B03414B7F CRC64;
     MTSYEIDIND AGMRLDRYVR KLFPKAKASL LYKSIRKKNI TVNGKKAKEE DVLEIGDKVE
     VYFSDDTISK FSKTPRRIAG HFPKVVAESD DFIVMEKPVG ILSHGTGKKF ERNMVDDMLT
     YLIHEKSYNP RLENTFIPSI CNRLDRNTSG LILGAKTAEG LRDANRWIRE RKLKKYYLTI
     VEGHLESERT VENRLEKEED KNRMVEGDDG KFAKGIYRPL DFKNGFTLVE AELVTGRTHQ
     IRQQLASIGH PIVGDQKYGK KSRRFPELHH QLLHAYRLVF PPSDYGAFSE KTVICEPRGK
     FQGAMMSIDL RYK
//