ID A0A135L4G4_9BACI Unreviewed; 1192 AA.
AC A0A135L4G4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=U473_07585 {ECO:0000313|EMBL:KXG43882.1};
OS Tepidibacillus decaturensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Tepidibacillus.
OX NCBI_TaxID=1413211 {ECO:0000313|EMBL:KXG43882.1, ECO:0000313|Proteomes:UP000070352};
RN [1] {ECO:0000313|EMBL:KXG43882.1, ECO:0000313|Proteomes:UP000070352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z9 {ECO:0000313|EMBL:KXG43882.1,
RC ECO:0000313|Proteomes:UP000070352};
RA Dong Y., Chang J.Y., Sanford R., Fouke B.W.;
RT "Draft Genome for Tepidibacillus decaturensis nov. sp. Strain Z9, an
RT Anaerobic, Moderately Thermophilic and Heterotrophic Bacterium from Deep
RT Subsurface of the Illinois Basin, USA.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXG43882.1}.
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DR EMBL; LSKU01000001; KXG43882.1; -; Genomic_DNA.
DR RefSeq; WP_068724936.1; NZ_LSKU01000001.1.
DR AlphaFoldDB; A0A135L4G4; -.
DR STRING; 1413211.U473_07585; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000070352; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000070352}.
FT DOMAIN 3..444
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 457..736
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT COILED 1142..1169
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1192 AA; 139413 MW; C71951CF69711014 CRC64;
MAFPLTDEQR FAVDTLHLNC IVPAGAGSGK TRVLVERYLK IIEKYADVPN IIEQIVAITF
TEKAAKEMKE RVRKGMVERR DQAFESGDLD AANLWRNNIQ RLERASISTI HSFCAKILRE
FPVEAKVDPE FQVLEATDTK WILADTIERE FKKFLKEEKE KGISPFYQWV SKAGFSRVFK
QLQKVYEQIS NTGIDFTQIK ELTEAQFRFS PYQWITGIDQ LIEAGDGLFN SDSNYKRFKE
YREQWPNVKQ QIVLAQEVGE GLQEAINQMI EITSGQFGKG LVSALRKKAN DQAKELNQWL
KAIEYHEWEK EYLTGFYPLL QKIDEAFRRE KNKRNSLDFD DLQFQAIRLL EENQEVKEKL
KKRISYLMID EFQDNNQVQK RLISLLLKDD KQTIQPGRLF VVGDPKQSIY RFRGADVHVF
KKMEQEISAM EGRIAPLQYN FRSHPDIIQF VNFFFEQVMS SDETSPNYYK EAIAKKEKIA
EDEVVEFIPI YHDTDDEQSV REKEATYIAK RIEQLVARGV EPKEITILFR SMSQVKIYEQ
ALLKKNIPYY VVGGRGFYQK QEIYDLLHVL KYLIDPTNKI ALAGILRSPM VAITDDTLYH
LLTKDIWNKP FNQWRSAIND LAQTEIEKVE HFVHWVSLLK KEVGRTKVSV LLKKILELTH
YQTILFALPQ GVQAVANVEK LIRQAEHFPG DNPYSVYEFL QRIERLIEES QEETEAAVES
ETGNTVKLMT IHQSKGLEFP YVFVPDLSRK PVNDDSLIRF NSKMGLSCKV PLLEGEWEEP
IRWLYLSKIE KELERDESVR VFYVAATRAE QKLILSGKVE QVKKEIEVSE VLSTNTWSKW
IDVVLKYETI SLGEAIWHYP LKNGEVGRIK VIHYDDQETL QESDSMDEVE AVKSSKKNTN
REIKVLNYTK PLQVSAEDTR YSVSSIKRYQ QCPRYYYFTD RLSLFSTLDW LNEEKIDFNE
EDVEMVGENT DENNGTNSLK TEQLTPSLKG TIVHQLLEAL THQPDQIGDW QKLLQKNLIK
QGIRVENIVD TDWEVFQTEV HQFVDYFQQS PFFRQQPSDS YLTEYDFILS LRNGKIFGTI
DRLDIHSDGT FSIIDYKTDK NVDKEIYEPQ ILTYALAIQK NLDLKPANGY LYFIRHNQIE
SIVIDEARLL EWEEQLEEIM NKINQSQAQE DFTQNLEHCS RCAFKNLCYK KD
//
