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Database: UniProt
Entry: A0A135LEV3_PENPA
LinkDB: A0A135LEV3_PENPA
Original site: A0A135LEV3_PENPA 
ID   A0A135LEV3_PENPA        Unreviewed;       998 AA.
AC   A0A135LEV3;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   07-NOV-2018, entry version 11.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=PGRI_012800 {ECO:0000313|EMBL:KXG47410.1};
OS   Penicillium patulum (Penicillium griseofulvum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=5078 {ECO:0000313|EMBL:KXG47410.1, ECO:0000313|Proteomes:UP000070168};
RN   [1] {ECO:0000313|EMBL:KXG47410.1, ECO:0000313|Proteomes:UP000070168}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PG3 {ECO:0000313|EMBL:KXG47410.1,
RC   ECO:0000313|Proteomes:UP000070168};
RX   PubMed=26729047; DOI=10.1186/s12864-015-2347-x;
RA   Banani H., Marcet-Houben M., Ballester A.R., Abbruscato P.,
RA   Gonzalez-Candelas L., Gabaldon T., Spadaro D.;
RT   "Genome sequencing and secondary metabolism of the postharvest
RT   pathogen Penicillium griseofulvum.";
RL   BMC Genomics 17:19-19(2016).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KXG47410.1}.
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DR   EMBL; LHQR01000065; KXG47410.1; -; Genomic_DNA.
DR   EnsemblFungi; KXG47410; KXG47410; PGRI_012800.
DR   Proteomes; UP000070168; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070168};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070168}.
FT   DOMAIN      421    546       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      711    796       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      884    996       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      184    204       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   998 AA;  114599 MW;  B943FBD0CE073445 CRC64;
     MDSDEILGQD IQPEKEEDLD EKYPNRPHNR GPTLPFHDLY LELFNPLSEL KKKPSGPAPS
     HRKVGPHGKG AASLNPFERR RDVIERFISR WRKEVGDDIY PALRLILPDK DRDRPMYGIK
     EKAIGKMLVK IMKINKESED GYNLLNWKLP GQGATARMAG DFAGRCFDVL SKRPMRTEPG
     DMTIEEVNEK LDKLSAASKE DEQLPILTEF YRRMNPEELL WLIRIILRQM KVGATERTFF
     DVWHPDAENL YSISSSLRRV CWELHDPNIR LEGEERGIAL MQCFQPQLAQ FQMHSFEKII
     ARMKPTEDDN VFWIEEKMDG ERMQLHMAPD ESIKGGRRFG FWSRKAKEYT YLYGNGLYDE
     NSALTRHLKD AFVDGVQSII LDGEMITWDP EQDAMVPFGT LKTAALSEQR NPFTNGPRPL
     FRVFDILHLN GRDLTKYTLR DRRNALEKTV RPVHRRFEIH AYEEASTTTE VEAALRKVVA
     EASEGLVLKN PRSPYRLNER HDDWMKVKPD YMTEFGESLD VVVIGGYYGS GHRGGALSSF
     LCGLRVDDKT QAPEKCWSFC KVGGGFTAAD YQELRHHTDG KWKKWDAKKP PTTYIELAGG
     DAQHERPDMW IKPSDSIVLC VKAASVAISD QFRMGLTLRF PRFKKLRKDK DWKSALSVQE
     FLDLKSNAEQ EHREKEFSVD NSRKKRVKRA TKKPLTVAGY DDNVDVQYLG PSGHVFDELN
     FFIMTESTVP EKKTKVQLEQ LVKANGGKFY QTKTAAADTI CVAERRTVKV ASLQKSGDQN
     IIRPSWLIDC VKQNEIDAGL PDLLLPFEPR HMFFMTEDKE EEVAANVDKF MDSYARDTTV
     DELKEIFKQM EENPEQPDQI PDPETVHRVE ALIQDKVNAG YTAPRGWLFR GLKFHFYSNG
     NQKDEQAPEL RKEYHRLHFA HNTARFAGAE NASSLESTGT THVIVDPETS SSADVSSLRQ
     SLAEKPGAKM PHLVSVSWVE ECWKNGTLLD EERFPVLR
//
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