ID A0A135SIJ5_9PEZI Unreviewed; 2649 AA.
AC A0A135SIJ5;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=KR domain-containing protein {ECO:0000313|EMBL:KXH35712.1};
GN ORFNames=CSIM01_05106 {ECO:0000313|EMBL:KXH35712.1};
OS Colletotrichum simmondsii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum acutatum species complex.
OX NCBI_TaxID=703756 {ECO:0000313|EMBL:KXH35712.1, ECO:0000313|Proteomes:UP000070328};
RN [1] {ECO:0000313|EMBL:KXH35712.1, ECO:0000313|Proteomes:UP000070328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS122122 {ECO:0000313|EMBL:KXH35712.1,
RC ECO:0000313|Proteomes:UP000070328};
RA Baroncelli R., Thon M.R.;
RT "The genome sequence of Colletotrichum simmondsii CBS122122.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXH35712.1}.
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DR EMBL; JFBX01000555; KXH35712.1; -; Genomic_DNA.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000070328; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..431
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2566..2643
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2649 AA; 289538 MW; 1033E2228EB86AD8 CRC64;
MKDQIQPIAI VGLNLKFPGD ATSAESFWEM LEKARNASSK VPSTRFNVDA FYHPDPTRLD
SMRVQNAHFM KEDPRAFDAA FFNMSPAEAS ILDPQQRGLL EGTYHTFENA GLAMERVAGS
RTSVFCASFG RDSDAIVARD PEFQSRYQAT SSGSSMLSNR ISHFFDLRGP SLTVDTACSS
GLYALHLACQ SILSGESDMS LVCGSNTYLT PECMSFPLSN AGFLSPDGRS YSFDHKANGY
ARGEGYAFVL LKPLSKALAD GDIIRSVIRA TGANQDGRTP SITQPSAAAQ VELIRRTYAS
GGLDLSETEY VEAHGTGTPV GDPIEVSAIG EVFRSHRSSP LWIGSVKSNI GHLEGASGLA
GLLKTVFSLE RAIIPPIADF EKVNPAIDVN ALGVRFPTRA TAWPATPSGI RRASVSSFGY
GGSNAHVVLD DAYNYLRIRG LTGNHLSVAK SNDSHMPCVA NSSTSVRAVE DQAPDAGISD
SVSDVSDDSG VIIGSGYDAE HNPISLLTFS AADEDGPRRQ ASALQDHVAT QQISRKRAQK
VFLADLAYTL SQKSILNWRA FAVVKSEANI GNNLTEILSP IMSVLSSKRP ELNFVFTGQG
AQYPRMGLKL IRYEVFRQSL MDCDEYLRSL GCEWSVLTEL RKAPGSSRIQ KPEISQPLCT
ALQIATVDLL RNWDIIPQSV CGHSSGEIAA AYCAGALDRQ SSWKVAYFRG VLAGRLASDG
SRSKTTMMSV GLGEAAVRPY LSNRLSVACI NSPANVTVSG PTNEIQLLFE RLEKEEIFVK
RLPVDFGYHS PAMEVVAAEY QDRIRDIGAP TGLTAERLRK ESLVSLYSST EGKLVSFEAV
TSPSYWVKNL VSPVLFSGAL EAMTGSKHGG QHFLVEIGPQ SALRRPVQDT LTPRLGNKAA
KKWQYVSVLK PNVDDDRSLM EALGSLWAAG IPISLSKPNQ ESTQISRKPK IMVDLPSYPF
NRSREFWEES RLSRNYAKRP CRRHALLGIR DRDWNPEEGS WRHLIRSQEN PWILDHALNG
SPLYPGSGML VMAIEAARQL ATPVESRIRG YQLDNVRFLR AVDVDDSERG TEAKIVMRRR
RQATNTSGQQ LCYDWRVFGT NGDDWNECAY GSIKVEVEPE QALGSEQAAA SEARRSRFET
SIKEQLQADV DKCRLVVHPS QLYKNMSKRS GFDYGPYFQL LKNISYDREG HATAMLSARD
YTSSMPYAGE DPCVVHPSTL DAVCHLQMVA LSQGGWNAVP TMMFSHLRKL WVSQKLFVAP
GNPQLRAATR ETMRAFREAE CRTLVTFADS NEPVLVLDGQ RGTAITNLKS ADTAATSRGD
SGQKFYGLDY KPDLSLLTVD AKSRYFAAAF KEDTRCRAPP RELIDRADAI ALHFIEAALE
QIDKEDKPLQ FDNHLARYVK WMRRVHLNRD TWTLESRGLS HLRIEEILDE ADGEPTQRLT
KKVGEHLHGI LKGEVNALQV IFEGNLANEF YHSDIFATNN SKMGAYINVL AHANPNLRLL
EVGAGTGSST GRILPYLAAQ GVEGGPPEAV RFGEYCYTDI SAGFFEKARE RFSYAASHMT
FKKLDLEKHP STQGFAEGAY DVVVAGNVLH ATSDLVQTLR YVKGLLRPGG VLVLGETVNL
DNVRDGLIFG LLPGWWLREG QWWSTNEEYQ DQGPLLTEEQ WTTVLKEAGF PGIQMAFRDH
EQKPHHRVSI IITTRPENES LSSQPSRVES PYRIIMDPTS AIQTSVAESL RSHLVSGSRP
RGADISSIVD ISSGDTKLNG DDAVISLLEL DASVLSSVAA EEFEAIKKIS LDTRFTLWLT
YGGAPKVTNP AAEVAIGFGR SVCSERGDQG FVTLNLSYRP ETPTAVTSAV NSIMRVVERL
HNVSCAGTDN ESEFSEDNGL ICIPRLMPTP HMDQALSIKQ SGGRLKSFTF NRDGPKPHIS
ITIETPGLLD TIFYAENDEA GKELQPGDIE IEVKATSMNF KDVMIALGQI PGRSFGFDGA
GVVSRVSRIS NLCPGDSVLF CSSTGGGFGT FVRCPELQTE KLPTGMSFQV AAAIPAVWST
VVYSLDHIAR LSRGETVLIH AAAGGVGQAA VQLAQLRGAK VFATVGSQAK RELVKQLFGL
PDDQIFNSRD ETFAQDVLHA TGGRGVDVVL NSLGGELLRQ SWECIAPFGR FIDIGKADII
ANNTLPMGPF NRNVTFSAVD LVVVHEEAKP LMKKILQDVT KLFEENPHLH EPKPLHVFSP
SKLEDAMRFL QGGKNTGKVI IDYASATDTV EYRPSQLQHG YNFDANATYV ISGGLGGLGR
EIARWMVSRG ARNLLLLSSR GAAGRPDALK LIQELEATDG VTVLAPACNV VDRGAVEDTL
LKASRELPPI KGCIQAAMVL RDDMLAKMSH SMFHETLGPK RAGSWNLHQL LPDDMDFFVL
LSSFCGIMGN RGQSNYAAGN AFEDALARHR VAQGLKGVSV DLVLVAEAGW ANVNYESVTQ
SLRAGHDNLT QAQLMELLDL LCDPGYDCAK PCAAQIVNMV DSAADLARMT QQGLLDWMQK
PMFSNLLRMG ETEASGNGHG VGGGNGDGSD DVNRLALVKA APDLSTASEI VTQGLVQKLA
KSLSVPIETL DVGKPAYVVG VDSLIAVEVR YWFMKQLLVE VPVFEILKNQ SITDLCQQVA
SKVLQSSSK
//
