ID A0A135TJV2_9PEZI Unreviewed; 2481 AA.
AC A0A135TJV2;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Beta-ketoacyl synthase domain-containing protein {ECO:0000313|EMBL:KXH48441.1};
GN ORFNames=CSIM01_04820 {ECO:0000313|EMBL:KXH48441.1};
OS Colletotrichum simmondsii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum acutatum species complex.
OX NCBI_TaxID=703756 {ECO:0000313|EMBL:KXH48441.1, ECO:0000313|Proteomes:UP000070328};
RN [1] {ECO:0000313|EMBL:KXH48441.1, ECO:0000313|Proteomes:UP000070328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS122122 {ECO:0000313|EMBL:KXH48441.1,
RC ECO:0000313|Proteomes:UP000070328};
RA Baroncelli R., Thon M.R.;
RT "The genome sequence of Colletotrichum simmondsii CBS122122.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXH48441.1}.
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DR EMBL; JFBX01000132; KXH48441.1; -; Genomic_DNA.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000070328; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05274; KR_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..447
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 304..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2481 AA; 272192 MW; C001A3C2235F415A CRC64;
MSTYKKPQSE PIAIVGTGCR FAGDVTSPTK LWDLLTNPRQ LSQEVPSNRF NAQGFYHPDG
EYHGATNATQ GYFLEEDHRV WDAGFFNITP KEAEAIDPQQ RIILEVVYEA LESAGYTLEK
YAGKKVAVYA GLMTADYDSL CQRDDITSNQ YFATGNSRAI LSNRISYFFN FRGPSMTIDT
ACSSSLVALH QAVLSLRSGE CEMACVAGAN LMITPEQFIS EASLHMLSPT GTSKMWDVSA
DGYARGEGFA ALFIKPLSQA LRDGDSIISI VRETGVNSDG RTQGITMPSP LAQAELIRDT
YRRSGLDSQN PSDRPQYFEA HGTGTQAGDP REAEAISTAF FGNEANTTAE SDDTKLVVGS
IKTVIGHTEG AAGLAGLLKV AHSMINNCIP PNLHLNTLNP SVKPFYGHLR IPVDVVPWPQ
APTGQPLRGS VNSFGFGGTN SHAILEKYEP SIHDEVAKHF APALEAPVSP LTTTPYDAEA
PAVGLPLVIS AKSQKSLVAV AQALRDFMVS TDKSADEVAY NLYAHRSALT YRTAISADSR
DGVIAALDNL LSKAGSSSNP ELGVRAKLDG GEVKILGIFT GQGAQWSGMG RKLFHSSSVY
RNTIENLEKV LKACPHPPTW SLIEELIHQE DASRINIAAL SQPLCTAVQI ALIDLLGSIN
VSFHTVVGHS SGEIGAAYAA GVLSARDAML ISYYRGMSAY LAGGKDGQKG MMMAVGMTRA
EASALCARDD IKGRIWVAAS NAPTSVTLSG DVDAVKALQV ELTEEKKFAR LLVVDTAYHS
AHMERPAAQY MEDLAGCGIE PRQRNSTVWI SSVYADGTEP SIEELKGPYW KDNMVKAVSF
YEAIDLALSS QGPFASAVEV GPHPALKGPV QQTVKAATGG ALSYAGLLDR KKDDRHAFAE
FLGFTWNYFG TEAIDWKLLV AQSSQPGLSS SRMDLPSYPW DHSQMHFRES RIAHQYQFRE
KGPHELLGVR TRDDTEFELR WRNILKLETV PWIQHHKFQG QALLPASAYC VLALDAAKAV
LNGREASVVE LTDLEFMSGI SLEANTYGVE ILVSLSIAPP STKGRLAGKI IEGVFTITSC
YADGVTPMQK NFTGNLRIYL GEPSEDALPT RDPSMAETLP ADTDSFYQMM LDIGLDYTGP
FRALQSIDRR YNFCSATLQK FHNTDTTGLG VSPATLDSCF HSVFAAVASP GDKSLWTSFL
PRSIEKIRFN LALCDGKPAD NASLVVDSVI TQEIPRTKTA TTKFVGDMSI YNPDGEMEIQ
VEGLMVASFA NSKPEDDKEL YLTTVCDLDP EHEIIAADLS QEDVATERIL LEACERVARF
YIHDDSLKDL SSSPVFFTPP ATPMSPPKAR SSETTPSPWQ QDTAETLDAY ILQSPFHHAL
SFIRLLGENI PDVLPAMLST IIQEAKQLHR FRSHVSRVVS QLAHRYPRMR VLGLTDPETA
LTKHVIDGFK GSFVSYTLGN ETEPDLMARV SSDAIKKKID TEHTKILDNE DNSSLQPFDM
VVLTTSIVKG AEQRSRLKQV QSLMKPGGFL ILIHESMSPL RDRLRRAFGV RRQADMPLTP
PEWPDLLDEC GFARVSKNAE QFFAPDFSLI VRQAESDIKQ AALSPLNSSV PKVMGHTLII
GAQENTADLS AEVHQKLDPL CSSIDIIADL DSLQPAIFNE ISSVIFLADL DEPMMSSMTP
ERLDLFRALM APEKVVLWAT MNSRAGNPEH AATFGFCRSM LAEIPSLKLQ MLDLDSRRDS
SDLVAETFLR LSMKALRSAA QDGKLLWSHE NEIFMEHGKR LIPRLLPWKE GNDRVNCPRR
LVADEVNTLK QCVEVVSAQS GDGSAVYTAN IVEETDIDDA VAIPDQSVIQ VKYSSVEVIN
FGLKYASHVC IGKEVTSGEL CLAMTKSNSS YVTVPNSCVF QLSSSNIEPK LLLGLVLRYL
VALSVAEDMM EQTVLLLEPD AALLECMKEV FEAKGANVIA CTTTGSKRKS YGQRYIHPYA
SNRELKALFP ADGASVIDFL PEGSELSETV LDCLPENCEY HSRFSLLTSE HVVALGDSMD
IEHLWETAIG KAITNVRSMN GRFSFPALES ISVPQLLDHT GSSKPFQILD WRAEREVQHI
AKPLFGTQLL RPYKTYVLVG LTRDMGQSLC NLFFEHGARH IVLASRNPNM QPQWIDDLSV
KGCEVRIERL DVTSIESVRA FKQRLAQEMP PVAGVINGAM VLDDRVFAQM DVETWNRVMR
PKTVGSSNLD EIFCEADMEF FIMTSSFAAP GGHGGQSNYA AANMYMNGLA ANRRIRGLAG
SVLNIGVIYG LGLLHRERTD IYAFLEKDGY PPISERDIHH MFLEAIVAGR PLDGQIYDIT
TGLSRYNANR EDKLHWQIDP RFSHFTFEDD DEGAEGEGQG KQSLKEKIKA VEGGAEEVAA
VLTEGFARYL EVVLGQGEGS VKGEHSVGEL GMDSLVAVEV RGWFWKVIER DVSVMKILGS
ASVAKLCLEV ADGYIKEKNK A
//
