ID   A0A135UHX1_9PEZI        Unreviewed;       708 AA.
AC   A0A135UHX1;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Thiamine pyrophosphate enzyme {ECO:0000313|EMBL:KXH59984.1};
GN   ORFNames=CSAL01_11981 {ECO:0000313|EMBL:KXH59984.1};
OS   Colletotrichum salicis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC   Colletotrichum acutatum species complex.
OX   NCBI_TaxID=1209931 {ECO:0000313|EMBL:KXH59984.1, ECO:0000313|Proteomes:UP000070121};
RN   [1] {ECO:0000313|EMBL:KXH59984.1, ECO:0000313|Proteomes:UP000070121}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 607.94 {ECO:0000313|EMBL:KXH59984.1,
RC   ECO:0000313|Proteomes:UP000070121};
RA   Baroncelli R., Thon M.R.;
RT   "The genome sequence of Colletotrichum salicis CBS 607.94.";
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXH59984.1}.
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DR   EMBL; JFFI01001443; KXH59984.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A135UHX1; -.
DR   STRING; 1209931.A0A135UHX1; -.
DR   OrthoDB; 2291769at2759; -.
DR   Proteomes; UP000070121; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004737; F:pyruvate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR18968:SF164; PYRUVATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000070121};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          107..239
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          311..417
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          517..702
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   REGION          54..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..75
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  76258 MW;  13A72B17A258EBF5 CRC64;
     MPFRQLPVPM ARCLRSFGPA GGRPGRLVRF NQTLAPSIAV VGGPARQLAG FSSAAPLHRS
     GGSTSPSSSH AGAGIKPTTS RPLVKDEFKA TIEQARNLSS KSTEMHTASF AFFEALWDAG
     VTHCFVNLGS DHPSIIEAMV KGQRERKGNF PRIITCPNEM VAMSMADGYA RLTGKPQCVI
     VHVDVGTQGL GAAVHNASCG RAPILVFAGL SPFTIEGEMR GSRTEYIHWI QDVPDQKQIV
     SQYCRYSGEL KTATNVKQMV NRALQFSKSD PQGPVYLCGA REVMEAEVEP YSIRQEDWDP
     VELGGLPKNA VNKIAEALAG AKEPLIVTGF GGRDHRFPGA LVELANTVKG LRVVDTGGSD
     MCFPADHPGW LGLRFGIEDA VNTADVIVVL DCDVPWINTL CHPKKDAKIF HIDVDPLKQQ
     MPVFYIAAQS RYRASSLLSI EQITAHLKGQ YATQLESAEA KEREAKVKES HKQLLAKIEE
     KAQPKADGEF GTGHLTRSLK KLCPEDTIWA IEAVTNTIFV HDNLQPTLPG SWINCGGGGL
     GWSGGGALGI KLATDFENGG NNKGKFVVQI VGDGTFLFSV PGSVYWIAKR YNIPILTIIL
     NNKGEWSINL SGDFETKADM KAGWNAPRRS LLLVHPDGEG SRATNEEINI SFDPAPDYAG
     IAKAAAGGDL FAARVDKAAD LDSVLKKAIE TVQGGQPAVL DIKVALGF
//