ID   A0A135VRY2_9ARCH        Unreviewed;       452 AA.
AC   A0A135VRY2;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KXH75162.1};
GN   ORFNames=AM325_11480 {ECO:0000313|EMBL:KXH75162.1};
OS   Candidatus Thorarchaeota archaeon SMTZ1-45.
OC   Archaea; Asgard group; Candidatus Thorarchaeota.
OX   NCBI_TaxID=1706444 {ECO:0000313|EMBL:KXH75162.1, ECO:0000313|Proteomes:UP000070149};
RN   [1] {ECO:0000313|EMBL:KXH75162.1, ECO:0000313|Proteomes:UP000070149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMTZ1-45 {ECO:0000313|EMBL:KXH75162.1};
RX   PubMed=26824177;
RA   Seitz K.W., Lazar C.S., Hinrichs K.U., Teske A.P., Baker B.J.;
RT   "Genomic reconstruction of a novel, deeply branched sediment archaeal
RT   phylum with pathways for acetogenesis and sulfur reduction.";
RL   ISME J. 0:0-0(2016).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXH75162.1}.
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DR   EMBL; LRSL01000014; KXH75162.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A135VRY2; -.
DR   STRING; 1706444.AM325_11480; -.
DR   Proteomes; UP000070149; Unassembled WGS sequence.
DR   GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR   Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR   PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          30..163
FT                   /note="Malic enzyme N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01274"
FT   DOMAIN          177..409
FT                   /note="Malic enzyme NAD-binding"
FT                   /evidence="ECO:0000259|SMART:SM00919"
SQ   SEQUENCE   452 AA;  49331 MW;  D1E8ACA900DBE848 CRC64;
     MSEEKLSVEE LKKKAEKPGK DALVLHPFYQ GKIMSIGKAP VRDFSDFAIW YTPGVAKPCL
     DIKENPNMAY EHLNKGNMVA VVSDGTRVLG LGDIGPLAAG PVMEGKAILF KYLGGVDAWP
     VCVDTKDADK IIEFVKLLQP SFGGINLEDI AKPKCYKVLE ELRNDPDIKI PVWHDDAQGT
     ATVVLAGVLG GLNVVKKDVE NITVAFLGVG AANTRTAYLL IAAGVDPKNI IMVDSQGAIY
     ADREDIVKEK DDDFFKYDLA QKTNPDRKTG DLGEVIDGMD VLITASRPVP GTVKKEWISK
     MATDSIVYAC ANPLPEIWPW DAKEAGARIV GTGRSDFDNQ INNSLGFPGI FRGTLDVRAS
     TITDEMCIAA AQALADLGAK EASERKVIPT MDQWELYPAE ATAVGMKAIE QGIAKKHWEE
     ENLYRHAEEI IKRARGASEI LYEKGFIPKA PI
//