ID A0A136HQE4_9GAMM Unreviewed; 2720 AA.
AC A0A136HQE4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:KXJ57589.1};
GN ORFNames=AXW15_06060 {ECO:0000313|EMBL:KXJ57589.1};
OS Neptuniibacter sp. Phe_28.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Neptuniibacter.
OX NCBI_TaxID=1795871 {ECO:0000313|EMBL:KXJ57589.1, ECO:0000313|Proteomes:UP000070472};
RN [1] {ECO:0000313|Proteomes:UP000070472}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Donaho J.A., Gutierrez T., Seitz K.W., Teske A.P.,
RA Baker B.J.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXJ57589.1}.
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DR EMBL; LSMR01000009; KXJ57589.1; -; Genomic_DNA.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000070472; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0018580; F:nitronate monooxygenase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR004136; NMO.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43074; OMEGA-3 POLYUNSATURATED FATTY ACID SYNTHASE PFAB-RELATED; 1.
DR PANTHER; PTHR43074:SF1; PKS_AT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF03060; NMO; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51412; Inosine monophosphate dehydrogenase (IMPDH); 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 681..1123
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2720 AA; 292349 MW; 67AFFB4B574C13C7 CRC64;
MNEFKKFVYT PAGYNDASLA IAACRAGGIG ILNAELSADS DKLLEQFALL SVHARNPFGI
KVDTPQKALL SAAAASVDQG FSYLIVDELV LASLAIEIKR LRKLGVTVLV EVTNAHTDAA
TLEKQVDGLM VKGYEAGGFV GEGSSFILLQ KWSAKTGLPL FVRGGITPHV AAACSAVGAK
GGVLESQVLL LKDSPLSERL SSFIGNLSGN ETIAVGDEEL GAYFRVLVRP GYREAQVFNN
NVSGRLVNPE DVLGKIDWDA PQKGLLPLGQ DVCFAKAWRE KYGYLSNVFA AIDQTIHDSM
QAAIQYKPLA ENAPLAEALG VRFPLVQGPM SRVSDSAEFA GAVADGGALP MLAFALLKGA
ALDKLLAETD KRLGDKPWGI GLLGFAPQSL LDEQIELAQK YKPQYAIIAG GRPDQAVKLE
QEGIQSFLHV PSANLIPLFL QEGARRFIFE GRECGGHIGP LSSFVLWSSM VDRLLEELES
GKTKGEGIQL LFAGGIHDAA SAAMVQVLAA PLLDKGVQVG ALMGSSYLFT KEIVESGAIV
PAFQKEVVEC EHTVSLESGP GHASRCAYTP FAKMFFDKRR EMIEQGVPVD EARATLDDLI
MGRLRIASKG CARLGENAKL TALDEATQHA DGMYMLGQVA TLRTELIDVE TLHAQVTEDS
HALLVANSMD SAQEDEADSS PVDIAIVGIS GLFPGANSTE EYWSNILDKV DAITEIPSHR
WDWRLYFDED RYSKDKIYSR WGGFIDDLAF DPTKYGMPPK SVEAVDPMQL MALEVASRTL
ADAGYDKRDF DRENASVIIG ASGGAGDVGM QYGLRAEMPR FKGDLPDHIA DILPEWTEDS
FAGILINVMA GRIANRLNFG GVNFTTDAAC ASSLAAIYQG ISELSAGRSN MVLAGGVDTV
QGPFGYLCFS KTQALSPRGR CSTFDVSGDG IVISEGIAMV AMKRLADAER DGDQVYAVIK
GVGGSSDGKA KGLTAPLPQG QLRAMRRAYK QAGFGPETVG LFEAHGTGTV AGDTAELEST
ISLLKEAGAG THQAVVGSVK TMIGHTKAAA GVAGLIKACL ALKHQTLPPH YGVTQPNNVL
MGEDCPLYLV DEAQPWIKKE QPRRAACSAF GFGGTNFHVV MEEYQGEYRP WMKKAVRTQG
PAELLIWSED TTEALIATLS NVAKELTSVA ALDLKKLSFN LINKHKSGLE TVTLVVRDQA
DFAEKVVATL GYLKDEISAL PEGAYYGNGQ KADGKVAAIF PGQGAQYPQM GRELAYTYST
VGNALSDADK LLKAPFEKRF AGCSLSDFIY PRGAYTPEQK TAATQALTST DVTQPALGAV
ETGLWRMLKT LGFKADMFAG HSYGEFVALH AAGAFDYETL VSLSEARGRF IVDEAKRAGD
ELGTMAAVQA TRDKVETAIK QIDGVIVANH NAPTQCIISG SKAGIAQAIE ALSQTDIMAT
PIPVAAAFHS SFVKPAQSHL AKLIESTKWI SPELPVYSNS TGDVHDASVA KLKSSMAAHL
VNPVEFVAEI EAMYRDGARI FVEVGPKSIL SRLTKQILGD RPHTTITLDN DQEGVYGLLS
ALANLVCEGV ELDLQPLLAG IQSELVSSNG LENYDSAAPI SKQTWMLNGS GARRATEAVR
QIGVTLEQVL AQNSVAAEAS SAGSVMTTVP SPQINENISY DRHHFKHNKE RKMDGRRQAP
NAGGPAVMAE YFDMMRQFLE SQESVMSMYL SGTPVPRSGE TRPQRLPKTA PQMAELSMEV
PVVAAPVAAP VVAPVAAPAP APVAVAPVAA PAPAPVAAPV AEAKPATDDA FDREKITQML
LEIVEDKTGY PSDMVGLDQK LEADLGIDSI KRIEIVGSLL KALPAAYGDA LGENRGQLNT
QENLTGMLDL LCDLPVGAAT SPFKVAGVRA EVSSTLSDSS FRHVVVPSPA PIEVNAKRAL
NIGHYVITRD AADIAGKLAA LLTDRGCTVQ IVEPSVLEDE EQILKFSAAV CAEKADLAGV
IHLAEIGSPA LMSESSVVDF KAVLNSNEKS FFLLLKGLSP AFSDAAHIVA ASGLGGAFGR
TNAVFNGLSL QSGFVGCLKS VSEERPALRV KAIDLDAEQS VGDLANILLE EMMLCGGRQE
VGYPAGKRTI FKTVAEVAPQ PAENATLDGL TVLATGGLRG ITAEVLREVA LPGNTLLLTG
RSPLPEPETA ETAALKTEAE LRQFFIAQVR DGILSLTPAE VMKKVAGVIG AREMLSNLQD
FQQRGAKVEY FAVDVTDESS MKGLLDAIYD KYGALHGVVH GAGIIEDKLL QDKTSESWSR
VVETKVLGLF HIQKYVRPES LRFLTVFSSV AGRYGNSGQL DYATANELLN RLCSQLNQLW
KNKVVVRSLC WGPWGPTQFG EGMVTAETEA KFAEKGVALV TAKAGRDVFR EEILQQPSEN
IEVICGIGPW EKHEATIGRV EFDESIPRIT GALLDNARVT AMPKGDQVVE FYLSDRHEYL
QQHRIDNIPV LPAAVALEIM SETVTALWPG WHVVEARDSR LLKGLQLDDL NQKLKVVVNP
PPYGSSDGFD VTVSLQSEKR MHYKAVLRLE QTYPESFTYE PEKHSDKQLS VETAYNEWLF
HGPCFQVIKK IAGLSQQGSV SDVETSTPAG WLSTVMVDDG WVFDPAMTDA AAQMALLWGR
TFNDQSALPA RFGKVMKFQE KLPEKLRMCF ARKESEQPNT IVSDVYFVDE KNNVALLIED
LECISSMELN RLGGTEKLAL
//
