ID A0A136J1M3_9PEZI Unreviewed; 1419 AA.
AC A0A136J1M3;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Transcription elongation factor Spt6 {ECO:0000256|ARBA:ARBA00020248, ECO:0000256|PIRNR:PIRNR036947};
GN ORFNames=Micbo1qcDRAFT_69685 {ECO:0000313|EMBL:KXJ91140.1};
OS Microdochium bolleyi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Microdochiaceae; Microdochium.
OX NCBI_TaxID=196109 {ECO:0000313|EMBL:KXJ91140.1, ECO:0000313|Proteomes:UP000070501};
RN [1] {ECO:0000313|Proteomes:UP000070501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J235TASD1 {ECO:0000313|Proteomes:UP000070501};
RG DOE Joint Genome Institute;
RA David A.S., May G., Haridas S., Lim J., Wang M., Labutti K., Lipzen A.,
RA Barry K., Grigoriev I.V.;
RT "Draft genome sequence of Microdochium bolleyi, a fungal endophyte of
RT beachgrass.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression. {ECO:0000256|ARBA:ARBA00025022,
CC ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036947}.
CC -!- SIMILARITY: Belongs to the SPT6 family. {ECO:0000256|ARBA:ARBA00009253,
CC ECO:0000256|PIRNR:PIRNR036947}.
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DR EMBL; KQ964251; KXJ91140.1; -; Genomic_DNA.
DR STRING; 196109.A0A136J1M3; -.
DR InParanoid; A0A136J1M3; -.
DR OrthoDB; 170310at2759; -.
DR Proteomes; UP000070501; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd09928; SH2_Cterm_SPT6_like; 1.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR049540; Spt6-like_S1.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035018; Spt6_SH2_C.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF21710; Spt6_S1; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50126; S1; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036947};
KW Reference proteome {ECO:0000313|Proteomes:UP000070501};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036947};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR036947}.
FT DOMAIN 1108..1177
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 1225..1323
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1419 AA; 164020 MW; B24AA669CC81851D CRC64;
MSNSMRDLVI GEAELDDDED DESFDEETGE ARQRERKRNG EMDDSSDDED DDDDEEEAAK
IREGFIVDED EEEEEDEDPE ERRQRRKRKR RQEREEDAQL DEEDLDLIGE TIPDADRNQA
SQKNYKRLKR GHQEEKARGS ERRGLDDMFD DEEEELDERP YGRPSHRAAV DEFDDFIEED
FPEDEDERMR QMEDLEVARP RERQIAGGVL DTAGLDKDAL EDMAAIFGNG EEYAWALDME
EEEEERQKGE QTLELKDVFE PSQLAEKLLT EADNEIRFTD EPERFQLDRK PFKHLQISAD
QFREESEWIM NLMWPQKQLS SDLHSPFHKA IGKVLEYFVV EELEVPYVFQ HRKDYLIHAR
KNRNPDYQTD SDAPQFIINA EKLLTQDDLW RILELDIQFR SLIEKRNALE KTYDNLRGIT
EGIDEMIPEM IPQAATIGEL QDIQDFVQFQ YAAQLKDLAS MNGTSKETKR PGTKASLFDR
VRKSKAYRFV KAYGISPDRL AQNALREGKK VLADDEQMLP IDLADALTDS DFPTGEQVLK
QGRQMYSEEM FMSPRMRKHF RIHFYQMGEV SCHRTEKGLR RIDEAHPFYE IKYLVNQSIS
DLARHPERFL KMMKAEEEGL IEVRLRLMNE REFKRQLLAE FKSDNYSELA DAWNEERRQV
LDLAFPKLER LIAKGVKDSL RTACQDELLK VCREEYSKRL DQAPYKPKGM VLGTAPRVLA
LSNGMGDPGR EPVFWVWVDE DGRIAETGQL GNLSRDEAQR DLFVDIVERR KPDVIGVSGF
SADTQRLVRD IEALVSEKKL EGAEYTDPDS DDYRSDLLEV VVVNDEVARL YKDSPRAQAE
NPTLNQVARY CVGLAKYLQN PMKEYAALGK DVASLLFHPS QHLLPPEKFL KHLDTAMVDM
VNLYGVDINE AVSDSYTANL LPYVAGLGPR KATSVIKAIN TNGGIVNSRD ELVGDPDNNK
LPVVGPRVWN NCASFLFIEY DATNPTSEPL DNTRVHPEDY ELGRKMAADA LELDEEDVKA
ETDENGPGAI VRKLFRDDEQ EKVNELILEE YAEQLEKNYS QRKRATLETI RAELQAPYEE
IRRPFATLQT DQIFTMFTGE TKESLAEGMI ISINIRVVKD DFAIAKLDCG IEGRIDAQEV
SYRPGTSMRD VIHMGQTVQA KILELNRKDF MTKLSLREDE LRKPYRKYND HDRDAWDFRL
ESDDQEALRE KDKATGRAQR MIKHPYFKTF NSAQAEEYLG SRAQGDVVVR PSSKGNDHLT
ITWKVADGVF QHIDVLELQK DSEFALGKQL RIGGKYTYTD LDELIESHVK AMAKKVNELM
NHEKFKQGSL ADLEKWLTSY SNANATQSIY LFGINPKHPG YFSLCFKVNK AAPIMKWHVK
VVPQAFEMMG SQYPDMRALC NGFKLRLNNE LSKMQQGRR
//
