ID A0A136KHP6_9BACT Unreviewed; 926 AA.
AC A0A136KHP6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Bacillolysin {ECO:0000313|EMBL:KXK08823.1};
DE EC=3.4.24.28 {ECO:0000313|EMBL:KXK08823.1};
GN Name=npr {ECO:0000313|EMBL:KXK08823.1};
GN ORFNames=UZ21_OP11001000378 {ECO:0000313|EMBL:KXK08823.1};
OS Microgenomates bacterium OLB22.
OC Bacteria; Candidatus Microgenomates.
OX NCBI_TaxID=1617428 {ECO:0000313|EMBL:KXK08823.1, ECO:0000313|Proteomes:UP000070562};
RN [1] {ECO:0000313|EMBL:KXK08823.1, ECO:0000313|Proteomes:UP000070562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OLB22 {ECO:0000313|EMBL:KXK08823.1};
RA Speth D.R., In T Zandt M., Guerrero Cruz S., Dutilh B.E., Jetten M.S.;
RT "Genome based microbial ecology of anammox granules in a full-scale
RT wastewater treatment system.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXK08823.1}.
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DR EMBL; LLEV01000006; KXK08823.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A136KHP6; -.
DR STRING; 1617428.UZ21_OP11001000378; -.
DR Proteomes; UP000070562; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 1.10.1330.10; Dockerin domain; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR036439; Dockerin_dom_sf.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KXK08823.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 311..413
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 417..564
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT REGION 590..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 407
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 483
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 926 AA; 99079 MW; DFD13413A7702244 CRC64;
MKSAQFEHNP FIQFILAGLG LYAVVMLTML SVDLLSPRQQ VKTKATGQPQ FDVSQVEQDQ
AIAGVLDGTI TVDVSSNKGL ITIPSDSSTD VAAAVKALEV LENTPLSLIP SDDMVQGIST
SDEITILPEG FSRTAKLVRT LDEAKVFTQA AAAPVKHYYF QQQIKVEGKL VPVFGTDARV
SMMQQDEEET VIGVGATVLG INPEPDALVM QTGSTDTQLL VDKAQAQAKV FLDNPALNVS
LCVGSALEDE IVNKSILGIS SDTTNYLTKR VPLCVDEQQD IKVLNVFIDP QTQEAIFIEP
LIYDALQRRV SDCSTGSCQV KRTEGSGPSN SAEADKAYDL LKKVYDYFKT KHNRDSFDGR
GAPLVAEVNY SGAIASAGGA RCPNAVWLGA KMAACRGLVL DDVWAHEITH GVTFTTSNLL
YQNQSGALNE SFSDIFGWAV DPDDFAMGNI RRLDDPTRSQ RPQPDKLFSP LYHTKSTDQG
GVHINSGILN KAFYLMVAGG NFNDCTIQKA DPERVLEAIY KALTVYLNRT SNFKSAYTAI
NRACADIHGA SSPTCATIEA SMQATQMDQM GSGQTCPECN STRGKVATCA GKGPQGGGDS
QPPQNPQPSG STRVPANPPR STATPRPTAR IGGSPNTGNR YPTTSQRAPT GSAESPVGGN
VKSIDPVTEC PVTAPTSVER AYSAVRVTCT DGRSSLLQKQ TCTPLGGYKA DATTFCAGSS
PPAPRDGGEN TPAPVPGNPQ ETGDTVAVVF QVQLQGVTDK IPPQHAIIPM RVGLSSRALD
RPLYVDTEAK ARLDGKTVLW EGKAIFKADP RLSYQILLKG PVHIQRKFCH EVVQEREPGA
YLCAGSSIPV SQGTIHLNAS TVPLFACDVP EQNGICNSLD LSVIKDGIGS IQPAIIIRCD
MNLDGVCNAQ DYVIALQAFL IRLDEE
//
