ID A0A136KTT9_9CHLR Unreviewed; 1141 AA.
AC A0A136KTT9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:KXK12782.1};
GN ORFNames=UZ14_CFX002002018 {ECO:0000313|EMBL:KXK12782.1};
OS Chloroflexi bacterium OLB14.
OC Bacteria; Chloroflexota; Tepidiformia.
OX NCBI_TaxID=1617415 {ECO:0000313|EMBL:KXK12782.1, ECO:0000313|Proteomes:UP000070321};
RN [1] {ECO:0000313|EMBL:KXK12782.1, ECO:0000313|Proteomes:UP000070321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OLB14 {ECO:0000313|EMBL:KXK12782.1};
RA Speth D.R., In T Zandt M., Guerrero Cruz S., Jetten M.S., Dutilh B.E.;
RT "Genome based microbial ecology of anammox granules in a full-scale
RT wastewater treatment system.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXK12782.1}.
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DR EMBL; LMZR01000048; KXK12782.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A136KTT9; -.
DR STRING; 1617415.UZ14_CFX002002018; -.
DR PATRIC; fig|1617415.3.peg.2038; -.
DR Proteomes; UP000070321; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 602..763
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 784..938
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1141 AA; 129258 MW; 66450B5855A81B15 CRC64;
MKQLLESFRA LPQYQNLLKD INASQSISGL GLPRSARLPV LATLHADINQ PILLITDRAD
HALSMFDELG FWVKSARYLF AEPNPLFYED AAWGVTTRRE RLQVLTALSS YHLPFVKKPE
TPPIIVTSVR ALMTRTLPRR DFLKACKKLS VNSINQTDSL MREWARIGYQ RVNTVLEPGQ
FSSRGGILDV WATTELHPVR LDFFGDEIET IRTFDPATQR TLEKLENILI TPAREFLADT
TETETQLSEF HIPLIHSQPA SLLDYLPQKT FVLVDDFSLI DVMANEVEEQ AIKFKSESIK
EGTLAESFPV PYIPWSELND SVSEFTNVEL SSSSVETREL ENSFTQVFGH DERFGGRLKP
FIDYLFPIIE KGEQVFIVSR QSQRLQELWF EHYPESDFTN LEFIESSLSE GFTFALGGVP
AAEYGGLSKL HLITDSEIFG WERPQPRARQ RKTADTPESL YADLQAGDYV VHVDHGIGRF
GGLIQRQMDG HEREYLTVEY DREDILYVPV HQADRLTRYV GADGGKPSLD NLGGQAWAET
KSKVKEAVQK VAEDLLDLYA RRQVVEGFAF DVDTQWQKEL EDSFPYVETD DQKRAIADIK
RDMERARPMD RLLCGDVGYG KTEVALRAAF KAVMNGKQTA VLVPTTVLAQ QHYETFSQRL
AAFPVKVEML SRFRTPREQT EILHKLAIGE VDIIIGTHRL ISADVSFKDL GLVVIDEEQR
FGVTHKEHLK KLRTEVDVLT LTATPIPRTL YMALTGVRDI SNLNTPPEER LPIITHVGPY
SPRLVRQAIL RELERGGQIF FVHNRVQTIE AMKAHLEKLV PEASVDIGHG QMPENQLSAV
MHRFNTGEID ILLSTTIIES GLDIPNANTL IVDRADTFGL AQLYQLRGRV GRGAMRAYAY
FFRHNKMSPT QDGQQRLEVI AENTQLGAGY SIAMRDLEIR GAGELLGTRQ HGFIQAVGFH
LYTRMLADAV RRLRKIANDV LKVDSEKLDN ALSTFNLPLS MPVNVELPLA VGIPATYISD
SDLRLRLYRR MADLRDETEL DALGSEFRDR FGIIPEMLQN LLYQMRVKLR AEKIGLASVN
WEAGQILLKY PVTNNGQEEK RLADLENGVR GGKSAYWITL SKDEVWTVKL LDVLAQLGDK
T
//
