ID   A0A136PW11_9ACTN        Unreviewed;      1372 AA.
AC   A0A136PW11;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=AWW66_07105 {ECO:0000313|EMBL:KXK62680.1};
OS   Micromonospora rosaria.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=47874 {ECO:0000313|EMBL:KXK62680.1, ECO:0000313|Proteomes:UP000070620};
RN   [1] {ECO:0000313|EMBL:KXK62680.1, ECO:0000313|Proteomes:UP000070620}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 803 {ECO:0000313|EMBL:KXK62680.1,
RC   ECO:0000313|Proteomes:UP000070620};
RA   Yang H., He X., Zhu D.;
RT   "Whole genome sequence and analysis of Micromonospora rosaria DSM 803,
RT   which can produce antibacterial substance rosamicin.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXK62680.1}.
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DR   EMBL; LRQV01000015; KXK62680.1; -; Genomic_DNA.
DR   RefSeq; WP_067361508.1; NZ_LRQV01000015.1.
DR   OrthoDB; 4280289at2; -.
DR   Proteomes; UP000070620; Unassembled WGS sequence.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070620};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          503..581
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
SQ   SEQUENCE   1372 AA;  152228 MW;  4C018BE3DAA0BF71 CRC64;
     MSSPGLQAIH AVGGVVPPGL LARIQAGELK NPAGLTPASY HLIGRETVRD AASRAWSYLR
     SAWTAWREHT ATQAPGAHGT TAAQQRWLLV LLRELGYGQV PALPSGYTID DRNYPVSHAW
     QHVPIHLLGP TADLNHRNPD LPGAARAPQA MLQELLNRSD DHLWGILSNG LRLRLLRDST
     ALAGSAYLEF DLETIFDGEL YPEFLLLWQL CHVSRLEQRP DDTGTTTPAG CWLEIWRGEA
     ADAGTRLLER LRDGVADALA ALGTGFIRHP ANQPLTTALR DGNLSTAQYH RALLRLVYRL
     LFCFVAEDRN ALLHPDAATQ ARERYQQYFS TARLRRLSRS RAGSPHPDLW HAQRLVLRAL
     GGDGHPGLGL PALAGLFDPD PHLPALDGLP FDPLLGCELT NEDLLSAIRK LAWVALPGQR
     IQPVDYHNLG AEELGSVYES LLELVPRLDL TDRVFRLVTI SGNDRKTTGS YYTPPSLVSA
     LLDTALDPLL DEALTGAANP ADAETRLLAL TVCDPACGSG HFLVAAARRI ARRLAQVRSG
     DDEPTPAQVQ HALREVAGNC IYGVDLNDLA AELAKVSLWM EALEPGKPLG FLDARIRIGN
     SLLGATPALL HRDLPDGAFK ELDGDDKATA AAVRKNNKAQ ATVRLEIQAG NERGYAQDAF
     VFSSGPDVSN ADLAAQRAAL LDLPDDVNAI RSQAARWEEH EQSDAYQAKH RHADTWCAAF
     VWPMPARVPG TEYPVPEPPT NAIMRAIAAD PLDRTNDQFT GYAQHLAAQY RFFHWHLEFP
     EIFRVDETTI ETTAQGWDGG FSCILGNPPW EKIEVNKQEF FASRDPAIAE AANDAARELL
     IDALAEEDPV LFSKYRQERR RIEGVTAFVR YSDRYLLTSS GRLNTYAVFA ETVRSLMSPI
     GRLGIIVPTG IATDATTQHY FRDLVERRSL VAIFDFENEE KVFPSVHNQY RFALLVLSGR
     PSGQAVLAFR ARQARQIAER SYTITPDEIL RLNPNTGTCP VFVARRDAEI TIGIYNRIPV
     LWRDQDPLGN PWSVSFAQGL FNMATGSRHF INADVAMESG WILEGNRFTK DGENLLPLYE
     AKLAHHYDHR FSTYEGATQE QLNKGTLPRL EDAAHADPSL GVKPRYWVPE SLVEEKLAGD
     PERGKPAWPH DWLLGWRDIA RSVDERTIIS TVIPRTAVGD KFLLARAQHQ PVAALQANLS
     AFVLDFTARQ KATGASFKYF LMRQLPILPP EIYAQESPWS GAASLSDWIT PRVLELSYTA
     YDLEGYAVEL GDDGPPFVWD RSRRATLRAE LDAAYFHLYG VTRDDVDYIM NTFKVVRERD
     EKAYGEYRTK RMILEIFDAM QEATVTGVPY VTTLDPPPGA GIRHPARKEA LG
//