ID   A0A136Q576_9FIRM        Unreviewed;       719 AA.
AC   A0A136Q576;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:KXK65838.1};
GN   ORFNames=HMPREF3293_01331 {ECO:0000313|EMBL:KXK65838.1};
OS   Christensenella minuta.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Christensenellaceae;
OC   Christensenella.
OX   NCBI_TaxID=626937 {ECO:0000313|EMBL:KXK65838.1, ECO:0000313|Proteomes:UP000070366};
RN   [1] {ECO:0000313|EMBL:KXK65838.1, ECO:0000313|Proteomes:UP000070366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22607 {ECO:0000313|EMBL:KXK65838.1,
RC   ECO:0000313|Proteomes:UP000070366};
RA   Wen L., He K., Yang H.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXK65838.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LSZW01000055; KXK65838.1; -; Genomic_DNA.
DR   RefSeq; WP_066521041.1; NZ_MAIR01000004.1.
DR   AlphaFoldDB; A0A136Q576; -.
DR   STRING; 626937.HMPREF3293_01331; -.
DR   KEGG; cmiu:B1H56_12440; -.
DR   PATRIC; fig|626937.4.peg.1313; -.
DR   OrthoDB; 9766847at2; -.
DR   Proteomes; UP000070366; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR007887; MecA_N.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627:SF25; PENICILLIN-BINDING PROTEIN 3; 1.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   Pfam; PF05223; MecA_N; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070366};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..719
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5039661222"
FT   DOMAIN          40..148
FT                   /note="NTF2-like N-terminal transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF05223"
FT   DOMAIN          155..322
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          363..695
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          441..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   719 AA;  78713 MW;  B220FB70BA7D7782 CRC64;
     MKKKLLIYIL VPLLLLVFTG AAFTGCSTLT DSADSVGGAF VNKLVARDYS GAFDYVYVLT
     ADVGTRDEFV ARFTNIYDAL EVSDVKLVSR SVEPVSDNEY ELKYTLALTS RLLGVLTYDY
     SADIVAGPQG YTVLYTPSLI LPMLEEGDRV RSTTQEGARG EIFSADGAVL AKNDYADSVY
     IDLEKGPDIE EVKAFLTANF SVDAETIQKK YDNAVEKGYP LEVLLSYPKG TITDEQKEAV
     AGINGLGFDD SRFSPVRYYP LKDDAAHIIG YLGSPSDEQL AANEDLTEYS TVGKSGLEMQ
     YEEVLRGSDG RIIYIEDEKG SLKQVLFEDE KTDGQNIELS IDSKTQERAY TLMASNLVDG
     QSGAVIVMDY STGAVEAMVS YPSFDNNLFN FPLDEATWNY YNGDEDHPLI NRAIQSAYMP
     GSSFKPFSSL PAIEGGLLDA DSVPPITKKP PHSEGNEESG SHSWTPDIEG WHSGAIYSKT
     VAESPYNYEM AMKSSDNIFF AYYALQAGVD PFESYMEKIG IGEAPQFELP VTASSMLSQS
     EDEVDWLDWL ARTGYGTGEL VITPLQLACM YTAIENGGTM VNPHIVNRTF TIEGEDETET
     TVEETSVSAF KEGTMSQKAI DIIKPALKRV MVDGTGYEAR LGDRDVLGKT GTAQVGANNS
     REVNWIIALN QEDGKLYMVV VETDTDEGTK PKTSILRGLA DESAYSRMLS GVSSSGEEE
//