ID A0A136WFM6_9FIRM Unreviewed; 1001 AA.
AC A0A136WFM6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Stage 0 sporulation protein A homolog {ECO:0000256|ARBA:ARBA00018672};
GN Name=cph2_2 {ECO:0000313|EMBL:KXL53304.1};
GN ORFNames=CLNEO_12750 {ECO:0000313|EMBL:KXL53304.1};
OS Anaerotignum neopropionicum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Anaerotignum.
OX NCBI_TaxID=36847 {ECO:0000313|EMBL:KXL53304.1, ECO:0000313|Proteomes:UP000070539};
RN [1] {ECO:0000313|EMBL:KXL53304.1, ECO:0000313|Proteomes:UP000070539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM-3847 {ECO:0000313|EMBL:KXL53304.1,
RC ECO:0000313|Proteomes:UP000070539};
RA Poehlein A., Beck M.H., Bengelsdorf F.R., Daniel R., Duerre P.;
RT "Genome sequence of Clostridium neopropionicum X4, DSM-3847.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play the central regulatory role in sporulation. It may
CC be an element of the effector pathway responsible for the activation of
CC sporulation genes in response to nutritional stress. Spo0A may act in
CC concert with spo0H (a sigma factor) to control the expression of some
CC genes that are critical to the sporulation process.
CC {ECO:0000256|ARBA:ARBA00024867}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00169}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXL53304.1}.
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DR EMBL; LRVM01000003; KXL53304.1; -; Genomic_DNA.
DR RefSeq; WP_066086186.1; NZ_LRVM01000003.1.
DR AlphaFoldDB; A0A136WFM6; -.
DR STRING; 36847.CLNEO_12750; -.
DR PATRIC; fig|36847.3.peg.1476; -.
DR OrthoDB; 9805474at2; -.
DR Proteomes; UP000070539; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00156; REC; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00254; GGDEF; 2.
DR PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR PANTHER; PTHR33121:SF78; CYCLIC DI-GMP PHOSPHODIESTERASE PDEI-RELATED; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 2.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 2.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 2.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000070539}.
FT DOMAIN 6..125
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 165..293
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 301..555
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT DOMAIN 751..882
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 1001 AA; 114925 MW; 5F36D73571E66F71 CRC64;
MPFKKNVLIV DDNKMNRQML SQVLYCQYKI LEAESGEEAL ELLHNSKLSI SVVLLRFALP
DMNGIEVLAE ISRDVFLRKI PVVLFARNDE LDSKTKAEVQ SLGVQNFIQP PFTAESVRQQ
IVNAILYSEK AKLLDFAQRD RLTSLYAREP FYHLITEVLE KNPDKKYDIL CSDIERFKLV
NELFGSEEGD ALLKFVAQMI EDKVKDVGIC GRIGGDIFAA LIPHQDQYSE QFFSESADFI
NQYNSNLHSV IKFGIYTIED RTLPANIMCA RACLALESIK GKYGMHCAYY DDSIRQKLLD
EQFILSNMKS ALVNREFVVF FQPKYDLLDE KICSAEALVR WKHPERGLIP PNQFIQIFEN
NGFITELDLY VLEETCKWVR SWIDRGNPMI PVSVNISRAD IFNSNLDAIL LSLLKKYGLD
PSHIHLEITE SAYTENAEQM IHGIKQLKEL GFVIEMDDFG SGYSSLNMLS ELPIDVLKLD
MRFVQNYDRS RDKRNIMSFV ISLAKWMNLK VVAEGVETEE QVNLLKLLGC HWVQGFFYSK
PLPLDAFETL IEQVNFSNTE YTLETAEGRA KPAHNILRLD VEKKNMLILD PTSKEFEPFQ
SVFDEKYCIL KANTMQETRD CIFNQKLKIS IVIFSVTKEI TLEHISEISL LCKQYDIPLI
TIHSSIELVK NAASLGAFHC IVKPYVLENL ENTVENTLCR MKVVQLQKEI KFSDAIIEMK
NRAEIDFLSG LLNHSELKIR MRDFYNQNHE ASGVFILIDI DHFKSINTSF GYNVGNKVIH
AVGKMLEAIF NDTNFIARID GDLFAVFIPF QMERQVLEQK LERVCHAMAY DNSDVSLTID
CSVGVCYAEN NTTTIEEMFN NAEIALLNAR KNQKGRFLFY FEGMKAPLNE NIQQQTFSFL
DDVSDGVFVC DALSGEIIYI NDAACKIMNM EKNNCIGAIG FGLFWNKNKK CELCLQLDDY
DTTFYEHDGY LNDGETKAHI KVRIDDWNGR TVKIHYLQKI G
//
